scholarly journals The Relationship between Alpha-Synuclein (SNCA) Gene Polymorphisms and Development Risk of Parkinson’s Disease

2020 ◽  
Author(s):  
Nevra Alkanli ◽  
Arzu Ay
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gene Polymorphisms ◽  
Alpha Synuclein ◽  
Snca Gene ◽  
The Relationship ◽  
Development Risk

Interaction between SNCA gene polymorphisms and T2DM with Parkinson’s disease

2020 ◽  
Vol 142 (5) ◽  
pp. 443-448
Author(s):  
Yajun Liu ◽  
Hongying Bai ◽  
Shuang Gen ◽  
Hui Zhang ◽  
Shanshan Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gene Polymorphisms ◽  
Snca Gene

Genetic analysis of SNCA gene polymorphisms in Parkinson’s disease in an Iranian population

Basal Ganglia ◽  
2017 ◽  
Vol 10 ◽  
pp. 4-7 ◽  
Author(s):  
Mahnoosh Rahimi ◽  
Mojdeh Akbari ◽  
Javad Jamshidi ◽  
Abbas Tafakhori ◽  
Babak Emamalizadeh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Analysis ◽  
Gene Polymorphisms ◽  
Iranian Population ◽  
Snca Gene

scholarly journals Decrease in ITGA7 Levels Is Associated with an Increase in α-Synuclein Levels in an MPTP-Induced Parkinson’s Disease Mouse Model and SH-SY5Y Cells

2021 ◽  
Vol 22 (23) ◽  
pp. 12616
Author(s):  
Sangeun Han ◽  
Min Hyung Seo ◽  
Sabina Lim ◽  
Sujung Yeo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Expression Patterns ◽  
Alpha Synuclein ◽  
Control Group ◽  
Potential Association ◽  
Sirna Knockdown ◽  
The Relationship ◽  
The Brain

We investigated the potential association between integrin α7 (ITGA7) and alpha-synuclein (α-syn) in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) mouse model. Tyrosine hydroxylase (TH), ITGA7, and α-syn expression in the substantia nigra (SN) of the brain were observed to examine the pathological characteristics of PD. To determine the relationship between ITGA7 and PD, the expression of TH and α-syn was investigated after ITGA7 siRNA knockdown in SH-SY5Y cells. The ITGA7 microarray signal was decreased in the SN of the MPTP group, indicating reduced ITGA7 expression compared to that in the control. The expression patterns of ITGA7 in the control group and those of α-syn in the MPTP group were similar on immunohistochemical staining. Reduction in ITGA7 expression by ITGA7 siRNA administration induced a decrease in TH expression and an increase in α-syn expression in SH-SY5Y cells. The decreased expression of ITGA7 significantly decreased the expression of bcl2 and increased the bax/bcl2 ratio in SH-SY5Y cells. These results suggest that reduced ITGA7 expression may be related to increased α-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. To the best of our knowledge, this is the first study to show an association between ITGA7 and PD.

scholarly journals Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Jinhua Zheng ◽  
Xinglong Yang ◽  
Quanzhen Zhao ◽  
Sijia Tian ◽  
Hongyan Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Genetic Basis ◽  
Univariate Analysis ◽  
Alpha Synuclein ◽  
Chinese Patients ◽  
Motor Symptom ◽  
Consecutive Series ◽  
Snca Gene

The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p<0.05). Based on logistic regression, a GG or GT genotype at rs11931074 was associated with higher risk of festination among patients with PD (OR 2.077, 95% CI 1.111–3.883, p=0.022), as was the TT genotype at rs894278 (OR 2.271, 95% CI 1.246–4.139, p=0.007). Therefore, we conclude that festination is associated with polymorphism at rs11931074 or rs894278 among patients with PD.

Conditional control of human wild-type and Parkinson's disease-associated mutant alpha-synuclein in transgenic mouse brain

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
S Nuber ◽  
T Schmidt ◽  
D Berg ◽  
M Neumann ◽  
C Holzmann ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transgenic Mouse ◽  
Mouse Brain ◽  
Alpha Synuclein ◽  
Wild Type ◽  
Conditional Control ◽  
Human Wild Type
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