Calcium Phosphate Cements in Tissue Engineering

2020 ◽  
Author(s):  
Manuel Pedro Fernandes Graça ◽  
Sílvia Rodrigues Gavinho
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cements

Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications

2009 ◽  
Vol 5 (7) ◽  
pp. 2752-2762 ◽  
Author(s):  
M. Espanol ◽  
R.A. Perez ◽  
E.B. Montufar ◽  
C. Marichal ◽  
A. Sacco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Engineering Applications ◽  
Calcium Phosphate Cements

Development of Novel Biodegradable Amino Acid Ester Based Polyphosphazene– Hydroxyapatite Composites for Bone Tissue Engineering

2004 ◽  
Vol 845 ◽  
Author(s):  
Swaminathan Sethuraman ◽  
Lakshmi S. Nair ◽  
Anurima Singh ◽  
Jared D Bender ◽  
Yaser E. Greish ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Amino Acid Ester ◽  
Toxic Chemicals ◽  
Mineral Component ◽  
Physiological Temperature ◽  
Calcium Phosphate Cements ◽  
Porous Microstructure

ASTRACT:Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P – 1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

scholarly journals Regenerating Craniofacial Dental Defects With Calcium Phosphate Cement Scaffolds: Current Status and Innovative Scope Review

2021 ◽  
Vol 2 ◽  
Author(s):  
Rashed A. Alsahafi ◽  
Heba Ahmed Mitwalli ◽  
Abdulrahman A. Balhaddad ◽  
Michael D. Weir ◽  
Hockin H. K. Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Cement ◽  
Current Status ◽  
Craniofacial Bone ◽  
Calcium Phosphate Cements ◽  
And Performance

The management and treatment of dental and craniofacial injuries have continued to evolve throughout the last several decades. Limitations with autograft, allograft, and synthetics created the need for more advanced approaches in tissue engineering. Calcium phosphate cements (CPC) are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. This review focuses on the up-to-date performance of calcium phosphate cement (CPC) scaffolds and upcoming promising dental and craniofacial bone regeneration strategies. First, we summarized the barriers encountered in CPC scaffold development. Second, we compiled the most up to date in vitro and in vivo literature. Then, we conducted a systematic search of scientific articles in MEDLINE and EMBASE to screen the related studies. Lastly, we revealed the current developments to effectively design CPC scaffolds and track the enhanced viability and therapeutic efficacy to overcome the current limitations and upcoming perspectives. Finally, we presented a timely and opportune review article focusing on the significant potential of CPC scaffolds for dental and craniofacial bone regeneration, which will be discussed thoroughly. CPC offers multiple capabilities that may be considered toward the oral defects, expecting a future outlook in nanotechnology design and performance.

3D-printing of porous calcium phosphate cements for bone tissue engineering

2016 ◽  
Vol 32 ◽  
pp. e56-e57 ◽  
Author(s):  
K. Khoshroo ◽  
T. Almela ◽  
M. Tahriri ◽  
F. Fahimipour ◽  
Z. Metalwala ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Cements

scholarly journals Factors influencing the drug release from calcium phosphate cements

2021 ◽  
Author(s):  
Marco Fosca ◽  
Julietta V. Rau ◽  
Vuk Uskoković
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Calcium Phosphate Cements ◽  
Factors Influencing

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering

2021 ◽  
Vol 12 ◽  
pp. 204173142110056
Author(s):  
Nupur Kohli ◽  
Vaibhav Sharma ◽  
Alodia Orera ◽  
Prasad Sawadkar ◽  
Nazanin Owji ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Chorioallantoic Membrane ◽  
Cam Assay ◽  
Clinical Model ◽  
Chick Chorioallantoic Membrane ◽  
Biomimetic Method ◽  
Alginate Scaffold

Due to the limitations of bone autografts, we aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue engineering applications. We used a porous, cross-linked and slowly biodegradable fibrin/alginate scaffold originally developed in our laboratory for wound healing, throughout which deposits of calcium phosphate (CaP) were evenly incorporated using an established biomimetic method. Material characterisation revealed the porous nature and confirmed the deposition of CaP precursor phases throughout the scaffolds. MC3T3-E1 cells adhered to the scaffolds, proliferated, migrated and differentiated down the osteogenic pathway during the culture period. Chick chorioallantoic membrane (CAM) assay results showed that the scaffolds were pro-angiogenic and biocompatible. The work presented here gave useful insights into the potential of these pro-angiogenic and osteogenic scaffolds for bone tissue engineering and merits further research in a pre-clinical model prior to its clinical translation.

scholarly journals Early-stage macroporosity enhancement in calcium phosphate cements by inclusion of poly(N-vinylpyrrolidone) particles as a porogen

2020 ◽  
Vol 23 ◽  
pp. 100901 ◽  
Author(s):  
Irene Lodoso-Torrecilla ◽  
Floris Stumpel ◽  
John A. Jansen ◽  
Jeroen J.J.P. van den Beucken
Keyword(s):  
Calcium Phosphate ◽  
Early Stage ◽  
Calcium Phosphate Cements

Creation of macroporous calcium phosphate cements as bone substitutes by using genipin-crosslinked gelatin microspheres

2008 ◽  
Vol 20 (4) ◽  
pp. 925-934 ◽  
Author(s):  
Meng Li ◽  
Xingyan Liu ◽  
Xudong Liu ◽  
Baofeng Ge ◽  
Keming Chen
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitutes ◽  
Gelatin Microspheres ◽  
Calcium Phosphate Cements
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