Surface Plasmon Resonance Sensors for Concentration and Reaction Kinetic Detections

Surface plasmon resonance (SPR) is an optical phenomenon that occurs on the metal (normally gold or silver) film surface and the light that excited this phenomenon changes with the refractive index of materials on the metal surface. SPR sensors are constructed based on this phenomenon and are used in fields of biological and chemical analyses, drug screening, environmental monitoring, and so on. Here, we will make an introduction to applications of SPR sensors on reaction kinetic and concentration detections. To make this chapter readily comprehensible, we will divide it into three portions. The first part will be an abbreviated depiction of surface plasmon excitation and constructions of an SPR sensor. Then, we will aim at an introduction to the bimolecular interactions in SPR sensors. At last, we will make a summary on applications of SPR sensors.

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Microstructured Surface Plasmon Resonance Sensor Based on Inkjet 3D Printing Using Photocurable Resins with Tailored Refractive Index

Polymers ◽

10.3390/polym13152518 ◽

2021 ◽

Vol 13 (15) ◽

pp. 2518

Author(s):

Nunzio Cennamo ◽

Lorena Saitta ◽

Claudio Tosto ◽

Francesco Arcadio ◽

Luigi Zeni ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

3D Printing ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Optical Sensor ◽

Low Cost ◽

3D Print ◽

Spr Sensor ◽

Resonance Sensor ◽

3D Printed

In this work, a novel approach to realize a plasmonic sensor is presented. The proposed optical sensor device is designed, manufactured, and experimentally tested. Two photo-curable resins are used to 3D print a surface plasmon resonance (SPR) sensor. Both numerical and experimental analyses are presented in the paper. The numerical and experimental results confirm that the 3D printed SPR sensor presents performances, in term of figure of merit (FOM), very similar to other SPR sensors made using plastic optical fibers (POFs). For the 3D printed sensor, the measured FOM is 13.6 versus 13.4 for the SPR-POF configuration. The cost analysis shows that the 3D printed SPR sensor can be manufactured at low cost (∼15 €) that is competitive with traditional sensors. The approach presented here allows to realize an innovative SPR sensor showing low-cost, 3D-printing manufacturing free design and the feasibility to be integrated with other optical devices on the same plastic planar support, thus opening undisclosed future for the optical sensor systems.

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An Enhanced Plastic Optical Fiber-Based Surface Plasmon Resonance Sensor with a Double-Sided Polished Structure

Sensors ◽

10.3390/s21041516 ◽

2021 ◽

Vol 21 (4) ◽

pp. 1516

Author(s):

Lian Liu ◽

Shijie Deng ◽

Jie Zheng ◽

Libo Yuan ◽

Hongchang Deng ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

Optical Fiber ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Low Cost ◽

Fiber Axis ◽

Plastic Optical Fiber ◽

Au Film ◽

Spr Sensor ◽

Resonance Sensor

An enhanced plastic optical fiber (POF)-based surface plasmon resonance (SPR) sensor is proposed by employing a double-sided polished structure. The sensor is fabricated by polishing two sides of the POF symmetrically along with the fiber axis, and a layer of Au film is deposited on each side of the polished region. The SPR can be excited on both polished surfaces with Au film coating, and the number of light reflections will be increased by using this structure. The simulation and experimental results show that the proposed sensor has an enhanced SPR effect. The visibility and full width at half maximum (FWHM) of spectrum can be improved for the high measured refractive index (RI). A sensitivity of 4284.8 nm/RIU is obtained for the double-sided POF-based SPR sensor when the measured liquid RI is 1.42. The proposed SPR sensor is easy fabrication and low cost, which can provide a larger measurement range and action area to the measured samples, and it has potential application prospects in the oil industry and biochemical sensing fields.

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Surface Plasmon Resonance Based on Molecularly Imprinted Polymeric Film for l-Phenylalanine Detection

Biosensors ◽

10.3390/bios11010021 ◽

2021 ◽

Vol 11 (1) ◽

pp. 21

Author(s):

Duygu Çimen ◽

Nilay Bereli ◽

Adil Denizli

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Limit Of Detection ◽

Kinetic Studies ◽

Force Microscopy ◽

Spr Sensor ◽

Atomic Force ◽

Analysis Technique ◽

Molecular Imprinting Technology

In this study, we designed a simple, rapid, sensitive and selective surface plasmon resonance (SPR) sensor for detection of L-phenylalaine by utilizing molecular imprinting technology. l-phenylalanine imprinted and non-imprinted poly(2-hydroxyethyl methacrylate-methacryloyl-l-phenylalanine) polymeric films were synthesized onto SPR chip surfaces using ultraviolet polymerization. l-phenyalanine imprinted and non-imprinted SPR sensors were characterized by using contact angle, atomic force microscopy and ellipsometry. After characterization studies, kinetic studies were carried out in the concentration range of 5.0–400.0 μM. The limit of detection and quantification were obtained as 0.0085 and 0.0285 μM, respectively. The response time for the test including equilibration, adsorption and desorption was approximately 9 min. The selectivity studies of the l-phenylalanine imprinted SPR sensor was performed in the presence of d-phenylalanine and l-tryptophan. Validation studies were carried out via enzyme-linked immunosorbent analysis technique in order to demonstrate the applicability and superiority of the l-phenylalanine imprinted SPR sensor.

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Cellulose and Vanadium Plasmonic Sensor to Measure Ni2+ Ions

Applied Sciences ◽

10.3390/app11072963 ◽

2021 ◽

Vol 11 (7) ◽

pp. 2963

Author(s):

Nur Alia Sheh Omar ◽

Yap Wing Fen ◽

Irmawati Ramli ◽

Umi Zulaikha Mohd Azmi ◽

Hazwani Suhaila Hashim ◽

...

Keyword(s):

Thin Film ◽

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Signal To Noise Ratio ◽

Affinity Constant ◽

Detection Accuracy ◽

Plasmonic Sensor ◽

Spr Sensor ◽

Resonance Sensor

A novel vanadium–cellulose composite thin film-based on angular interrogation surface plasmon resonance (SPR) sensor for ppb-level detection of Ni(II) ion was developed. Experimental results show that the sensor has a linear response to the Ni(II) ion concentrations in the range of 2–50 ppb with a determination coefficient (R2) of 0.9910. This SPR sensor can attain a maximum sensitivity (0.068° ppb−1), binding affinity constant (1.819 × 106 M−1), detection accuracy (0.3034 degree−1), and signal-to-noise-ratio (0.0276) for Ni(II) ion detection. The optical properties of thin-film targeting Ni(II) ions in different concentrations were obtained by fitting the SPR reflectance curves using the WinSpall program. All in all, the proposed Au/MPA/V–CNCs–CTA thin-film-based surface plasmon resonance sensor exhibits better sensing performance than the previous film-based sensor and demonstrates a wide and promising technology candidate for environmental monitoring applications in the future.

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Development of an Au/ZnO thin film surface plasmon resonance-based biosensor immunoassay for the detection of carbohydrate antigen 15‐3 in human saliva

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2012.09.001 ◽

2012 ◽

Vol 45 (18) ◽

pp. 1689-1693 ◽

Cited By ~ 27

Author(s):

Yang-Hung Liang ◽

Chia-Chen Chang ◽

Chien-Cheng Chen ◽

Yu Chu-Su ◽

Chii-Wann Lin

Keyword(s):

Thin Film ◽

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Film Surface ◽

Human Saliva ◽

Carbohydrate Antigen ◽

Zno Thin Film ◽

Thin Film Surface

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Novel high sensitivity SPR sensor based on surface plasmon resonance technology and IMI waveguide structure

Results in Physics ◽

10.1016/j.rinp.2020.103049 ◽

2020 ◽

Vol 17 ◽

pp. 103049

Author(s):

Jun Zhu ◽

Na Li

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

High Sensitivity ◽

Waveguide Structure ◽

Spr Sensor

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GeSe nanosheets modified surface plasmon resonance sensors for enhancing sensitivity

Nanophotonics ◽

10.1515/nanoph-2019-0170 ◽

2020 ◽

Vol 9 (2) ◽

pp. 327-336 ◽

Cited By ~ 5

Author(s):

Yuting Zhao ◽

Shuaiwen Gan ◽

Leiming Wu ◽

Jiaqi Zhu ◽

Yuanjiang Xiang ◽

...

Keyword(s):

Heavy Metal ◽

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

Germanium Selenide ◽

Spr Sensor ◽

Enhanced Sensitivity ◽

Sensing Technology ◽

Photovoltaic Applications ◽

Modified Surface

AbstractGermanium selenide (GeSe) nanosheets are stable and inexpensive and considered to have a great potential for photovoltaic applications, however we have demonstrated that GeSe nanosheets are also promising for sensing technology, in this paper. By spin-coating the GeSe nanosheets on the surface of noble metal (Au), we have obtained a surface plasmon resonance (SPR) sensor with significantly enhanced sensitivity, and the performance of the sensor is closely related to the thickness of the GeSe film. By detecting different refractive index solutions, we have obtained the optimized sensitivity with 3581.2 nm/RIU (which is nearly 80% improvement compared to traditional SPR sensors) and figure of merit with 14.37 RIU−1. Moreover, the proposed SPR sensor was vastly superior in sensing Pb2+ heavy metal ions after coating it with chitosan and GeSe composite. A maximum sensitivity of 30.38 nm/μg/l has been verified, which is nearly six times better than that of conventional SPR sensor. Our results demonstrated that GeSe nanosheets overlayer with modified SPR sensor has its great potential in heavy metal detection and chemical-specific molecular identification.

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