scholarly journals Localization Mechanisms of Radiopharmaceuticals

2021 ◽  
Author(s):  
Sana Komal ◽  
Sana Nadeem ◽  
Zahra Faheem ◽  
Arouma Raza ◽  
Komal Sarwer ◽  
...  
Keyword(s):  
Binding Site ◽  
Receptor Binding ◽  
Diagnostic Tool ◽  
Chemical Species ◽  
Metabolic Process ◽  
Receptor Binding Site ◽  
New Era ◽  
Specific Organ ◽  
Therapeutic Processes

Scintigraphic techniques have opened a new era of developments in the localization of infectious and cancerous foci. Diseases area targeting mechanisms of radiopharmaceuticals encompasses visualization, characterization, and measurement of physiological and biological functioning at targeted sites in addition to measure the area and density of the disease. The accumulation of a radiopharmaceutical at specific organ is based upon numerous processes such as enzymatic interactions, receptor binding site, transport of chemical species and elimination of damaged cells from circulation by a normal metabolic process. PET and SPECT are developing scanning techniques that provides effective diagnostic tool to identify pathophysiology of diseased cells. In this chapter, we are exploring and explaining different mechanisms of radiopharmaceutical localization for imaging and therapeutic processes. The knowledge of these mechanisms will help to develop target based new radiopharmaceuticals using variety of medically used radioisotopes either for imaging or therapy of diseased cells.

Analysis of the receptor-binding site of murine coronavirus spike protein.

1996 ◽  
Vol 70 (4) ◽  
pp. 2632-2636 ◽  
Author(s):  
H Suzuki ◽  
F Taguchi
Keyword(s):  
Binding Site ◽  
Receptor Binding ◽  
Spike Protein ◽  
Receptor Binding Site ◽  
Murine Coronavirus

scholarly journals Potent sialic acid inhibitors that target influenza A virus hemagglutinin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu-Jen Chang ◽  
Cheng-Yun Yeh ◽  
Ju-Chien Cheng ◽  
Yu-Qi Huang ◽  
Kai-Cheng Hsu ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Antiviral Activity ◽  
Binding Site ◽  
Influenza A Virus ◽  
Receptor Binding ◽  
Influenza A ◽  
The United States ◽  
Ligand Complex ◽  
Receptor Binding Site ◽  
Computational Strategy

AbstractEradicating influenza A virus (IAV) is difficult, due to its genetic drift and reassortment ability. As the infectious cycle is initiated by the influenza glycoprotein, hemagglutinin (HA), which mediates the binding of virions to terminal sialic acids moieties, HA is a tempting target of anti-influenza inhibitors. However, the complexity of the HA structure has prevented delineation of the structural characterization of the HA protein–ligand complex. Our computational strategy efficiently analyzed > 200,000 records of compounds held in the United States National Cancer Institute (NCI) database and identified potential HA inhibitors, by modeling the sialic acid (SA) receptor binding site (RBS) for the HA structure. Our modeling revealed that compound NSC85561 showed significant antiviral activity against the IAV H1N1 strain with EC50 values ranging from 2.31 to 2.53 µM and negligible cytotoxicity (CC50 > 700 µM). Using the NSC85561 compound as the template to generate 12 derivatives, robust bioassay results revealed the strongest antiviral efficacies with NSC47715 and NSC7223. Virtual screening clearly identified three SA receptor binding site inhibitors that were successfully validated in experimental data. Thus, our computational strategy has identified SA receptor binding site inhibitors against HA that show IAV-associated antiviral activity.

Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.

1993 ◽  
Vol 7 (7) ◽  
pp. 907-914
Author(s):  
E P Slater ◽  
H Hesse ◽  
J M Müller ◽  
M Beato
Keyword(s):  
Glucocorticoid Receptor ◽  
Binding Site ◽  
Receptor Binding ◽  
Alpha Amylase ◽  
Receptor Binding Site

Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

Science ◽  
1995 ◽  
Vol 268 (5209) ◽  
pp. 439-442 ◽  
Author(s):  
M. Nowak ◽  
P. Kearney ◽  
Sampson ◽  
M. Saks ◽  
C. Labarca ◽  
...  
Keyword(s):  
Amino Acid ◽  
Binding Site ◽  
Receptor Binding ◽  
Nicotinic Receptor ◽  
Unnatural Amino Acid ◽  
Amino Acid Incorporation ◽  
Receptor Binding Site ◽  
Intact Cells ◽  
Acid Incorporation

Monoclonal antibodies against human IgE. identification of an epitope sharing properties with the high-affinity receptor binding site

1991 ◽  
Vol 28 (8) ◽  
pp. 839-844 ◽  
Author(s):  
Jaime Moscoso del Prado ◽  
Lucía Jimeno ◽  
Teodoro Obispo ◽  
José Carreira
Keyword(s):  
Monoclonal Antibodies ◽  
Binding Site ◽  
Receptor Binding ◽  
Receptor Binding Site ◽  
High Affinity ◽  
High Affinity Receptor ◽  
Affinity Receptor ◽  
Epitope Sharing

Localization of an estrogen receptor binding site near the promoter of the uteroglobin gene

FEBS Letters ◽  
1990 ◽  
Vol 265 (1-2) ◽  
pp. 20-22 ◽  
Author(s):  
M.S.López de Haro ◽  
C. García ◽  
A. Nieto
Keyword(s):  
Estrogen Receptor ◽  
Binding Site ◽  
Receptor Binding ◽  
Receptor Binding Site ◽  
Estrogen Receptor Binding ◽  
Estrogen Receptor Binding Site

scholarly journals TwoBacillus sphaericusbinary toxins share the midgut receptor binding site: implications for resistance ofCulex pipienscomplex (Diptera: Culicidae) larvae

2004 ◽  
Vol 241 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Maria Helena Neves Lobo Silva-Filha ◽  
Cláudia Maria Fontes de Oliveira ◽  
Lêda Regis ◽  
Zhiming Yuan ◽  
Clara Martinez Rico ◽  
...  
Keyword(s):  
Binding Site ◽  
Receptor Binding ◽  
Receptor Binding Site

Mapping the Peripheral Benzodiazepine Receptor Binding Site by Conformationally Restrained Derivatives of 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195)

1997 ◽  
Vol 40 (18) ◽  
pp. 2910-2921 ◽  
Author(s):  
Andrea Cappelli ◽  
Maurizio Anzini ◽  
Salvatore Vomero ◽  
Pier G. De Benedetti ◽  
Maria Cristina Menziani ◽  
...  
Keyword(s):  
Binding Site ◽  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Peripheral Benzodiazepine Receptor ◽  
Receptor Binding Site ◽  
Conformationally Restrained ◽  
Derivatives Of

scholarly journals Immunization of rabbits with synthetic peptides derived from a highly conserved β-sheet epitope region underneath the receptor binding site of influenza A virus

2013 ◽  
pp. 233
Author(s):  
Shoji Ideno ◽  
Kaoru Sakai ◽  
Mikihiro Yunoki ◽  
Ritsuko Kubota-Koketsu ◽  
Yuji Inoue ◽  
...  
Keyword(s):  
Binding Site ◽  
Influenza A Virus ◽  
Receptor Binding ◽  
Synthetic Peptides ◽  
Influenza A ◽  
Beta Sheet ◽  
Receptor Binding Site ◽  
Epitope Region
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