scholarly journals The Association of HLA-DQ2 with Celiac Disease

2021 ◽  
Author(s):  
Federica Gualandris ◽  
Laura Castellani ◽  
Anna Falanga
Keyword(s):  
Celiac Disease ◽  
Healthy Subjects ◽  
Neurological Diseases ◽  
T Helper Lymphocytes ◽  
Class Ii Mhc ◽  
Genes Encoding ◽  
Surface Receptor ◽  
T Lymphoma ◽  
And Control

DQ2 is a surface receptor of class II MHC exposed on APC immune-competent cells. Its function is to recognize non-self-antigens and present them to CD4+ T-helper lymphocytes, which activate cytokine <21> production and control antibody production and cell response. The activation of T lymphocytes by peptides derived from gluten proteins and the production of antibodies directed against tTG in tissues where it is localized is the basis of the etiopathogenesis of celiac disease (CD). CD is frequently associated with the presence of specific HLA system genes encoding heterodimers DQ2 and DQ8, identifiable by the DQA1*0501/DQB1*0201 or DQA1*0501/DQB1*0202 and DQB1*0302 alleles. DQ2 is also associated with genetic, endocrinological and neurological diseases such as: type 1 diabetes, thyroiditis, pancreatitis and multiple sclerosis. Interactions between DQ2 and T lymphoma have also been demonstrated. The correlation between autoimmune diseases in patients with CD and therefore DQ2 is much more frequent than in healthy subjects.

Genetic Variants Confer Susceptibility to JIA, Type 1 Diabetes, and Celiac Disease

2011 ◽  
Vol 44 (2) ◽  
pp. 50
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Genetic Variants

Celiac disease and risk of subsequent type 1 diabetes

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
É Micskey ◽  
P Pánczél ◽  
L Blatniczky ◽  
K Lukács
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease

Increased prevalence of disordered eating in the dual diagnosis of type 1 diabetes mellitus and celiac disease

2019 ◽  
Author(s):  
Tokatly Latzer I ◽  
Rachmiel M ◽  
Zuckerman Levin N ◽  
Mazor-Aronovitch K ◽  
Landau Z ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Disordered Eating ◽  
Dual Diagnosis

Diagnostic Accuracy of Serologic Screening Tests for Celiac Disease in Asymptomatic Adults and Children with Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1579-P
Author(s):  
MICHELLE GOULD ◽  
FARID H. MAHMUD ◽  
ANTOINE B. CLARKE ◽  
ESTHER ASSOR ◽  
AMISH PARIKH ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Diagnostic Accuracy ◽  
Screening Tests ◽  
Adults And Children ◽  
Serologic Screening

224-LB: Celiac Disease Prevalence and Screening Practices in Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 224-LB
Author(s):  
JASON SLOANE ◽  
BIANCA PORNEALA ◽  
DEBORAH J. WEXLER
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Disease Prevalence ◽  
Screening Practices

1316-P: Celiac Disease in Youth with Type 1 Diabetes: Association with Age at Diabetes Diagnosis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1316-P
Author(s):  
ERIN ALVING ◽  
KRISTEN CARLIN ◽  
DALE LEE ◽  
ALISSA J. ROBERTS ◽  
JANE DICKERSON ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Diabetes Diagnosis

1293-P: Efficiency of Screening for Type 1 Diabetes and Celiac Disease in Various Health Care Settings: Autoimmunity Screening for Kids (ASK)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1293-P
Author(s):  
CRISTY R. GENO RASMUSSEN ◽  
KATHLEEN WAUGH ◽  
JUDITH BAXTER ◽  
ANDREA STECK ◽  
BRIGITTE I. FROHNERT ◽  
...  
Keyword(s):  
Health Care ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
P Efficiency ◽  
Health Care Settings

Prevalence of celiac disease in children and adolescents with type 1 diabetes - Authors' reply

2006 ◽  
Vol 82 (5) ◽  
pp. 401-401
Author(s):  
Jacqueline Araújo ◽  
Gisélia Alves Pontes da Silva ◽  
Francisco Montenegro de Melo
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Children And Adolescents

scholarly journals Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Melek Pehlivan ◽  
Tülay K. Ayna ◽  
Maşallah Baran ◽  
Mustafa Soyöz ◽  
Aslı Ö. Koçyiğit ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Disease Risk ◽  
Polymerase Chain Reaction Method ◽  
Control Group ◽  
Healthy Children ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Allele Specific ◽  
And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

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