scholarly journals The Influence of Protease Inhibitors on the Evolution of Hepatitis C in Patients with HIV and HCV Co-Infection

2021 ◽  
Author(s):  
Elena Dumea ◽  
Simona Claudia Cambrea
Keyword(s):  
Viral Load ◽  
Hepatitis C ◽  
Liver Damage ◽  
Cd8 T Cells ◽  
Antiretroviral Treatment ◽  
Non Invasive ◽  
Immunological Status ◽  
Severe Liver Damage ◽  
Negative Role

Prevalence of hepatitis C in HIV infected patients is much higher than in the general population. There is the possibility of viral clearance HCV, in some patients co-infected HIV and HCV, in the phase of immune reconstruction after antiretroviral treatment (ART). There are patients’ anti-HCV positive who initially did not show HCV viral load detected and after the start of ART becomes HCV viral load detectable. There are studies that described that immune restoration with increase in CD4+ and CD8+ T cells, from ART, was important in control of HCV viremia. Has been proposed hypothesis that direct or indirect effect of ART on HCV replication play a role in spontaneous resolution of HCV infection. We evaluated the co-infected patients with HIV and HCV under combined antiretroviral treatment, containing PI boosted with ritonavir in terms of immunological and virological status (for both infection) and also liver disease. Patients were evaluated for liver damage by non-invasive methods. We have shown that a small percentage of patients have severe liver damage. We demonstrated the negative role of HCV on immunological status and in liver fibrosis in co-infected patients. A high proportion of these HIV and HCV co-infected patients had no detectable viremia, higher than other studies published.

scholarly journals Fibrosis in Chronic Hepatitis C: Correlation between Immunohistochemically-Assessed Virus Load with Steatosis and Cellular Iron Content

2016 ◽  
Vol 4 (4) ◽  
pp. 578-584
Author(s):  
Maha Akl ◽  
Ali EL Hindawi ◽  
Maha Mosaad ◽  
Ahmed Montasser ◽  
Ahmed El Ray ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Cellular Iron ◽  
Iron Load ◽  
Cirrhotic Group ◽  
Sirius Red

AIM: We aimed study impact of hepatocytic viral load, steatosis, and iron load on fibrosis in chronic hepatitis C and role of VEGF and VEGFR overexpression in cirrhotic cases in evolving HCC.MATERIAL AND METHODS: Total of 120 cases were included from TBRI and Beaujon Hospital as chronic hepatitis C (CHC), post-hepatitis C cirrhosis, and HCC. Cases of CHC were stained for Sirius red, Prussian blue and immunohistochemically (IHC) for HCV-NS3/NS4. HCC were stained IHC for VEGF and by FISH.RESULTS: Stage of fibrosis was significantly correlated with inflammation in CHC (P < 0.01). Noticed iron load did not correlate with fibrosis. Steatosis was associated with higher inflammation and fibrosis. The cellular viral load did not correlate with inflammation, steatosis or fibrosis. VEGF by IHC was significantly higher in cases of HCC when compared to cirrhotic group (P < 0.001). Amplification of VEGFR2 was confirmed in 40% of cases of HCC. Scoring of VEGF by IHC was the good indicator  of VEGFR2 amplification by FISH (P < 0.005).CONCLUSION: Grade of inflammation is the factor affecting fibrosis in CHC. The degree of liver damage is not related to cellular viral load or iron load. Steatosis is associated with higher inflammation and fibrosis. VEGF by IHC is correlated with overexpression of VEGFR2 by FISH.

Evidence Against the Role of Hepatitis C Virus in Severe Liver Damage Occurring Early in the Course of Acute Leukemia in Children

1994 ◽  
Vol 13 (1-2) ◽  
pp. 119-122 ◽  
Author(s):  
Anna Locasciulli ◽  
Patrizia Pontisso ◽  
Daniela Cavalletto ◽  
Donatella Fraschini ◽  
Cornelio Uderzo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Leukemia ◽  
Liver Damage ◽  
Severe Liver ◽  
Severe Liver Damage ◽  
Leukemia In Children

The role of CCR5/CXCR3 expressing CD8+ cells in liver damage and viral control during persistent hepatitis C virus infection

2007 ◽  
Vol 47 (5) ◽  
pp. 632-641 ◽  
Author(s):  
Juan-Ramón Larrubia ◽  
Miryam Calvino ◽  
Selma Benito ◽  
Eduardo Sanz-de-Villalobos ◽  
Cristian Perna ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Damage ◽  
Hepatitis C Virus Infection ◽  
Viral Control ◽  
Cd8 Cells

scholarly journals ‘Favourable’ IL28B polymorphisms are associated with a marked increase in baseline viral load in hepatitis C virus subtype 3a infection and do not predict a sustained virological response after 24 weeks of therapy

2013 ◽  
Vol 94 (6) ◽  
pp. 1259-1265 ◽  
Author(s):  
Cristina Bucci ◽  
Annette von Delft ◽  
Annabel Christian ◽  
Vicki M. Flemming ◽  
Abby Harrison ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Response To Therapy ◽  
Baseline Viral Load ◽  
Median Viral Load ◽  
Host Genetic

IL28B host genetic make-up is known to play a critical role in the outcome of genotype 1 hepatitis C virus (HCV) infection in the context of both primary infection and therapy. However, the role of IL28B in subtype 3a infection remains unclear, and has not yet been assessed in the UK population where subtype 3a is dominant. In this study, we evaluated the role of the IL28B single-nucleotide polymorphism rs8099917 in 201 patients recruited from two well-defined cohorts (from Nottingham and Oxford), treated with the standard-of-care therapy of pegylated interferon and ribavirin for 24 weeks. We showed that the ‘favourable’ IL28B gene was associated with a rapid virological response to therapy at 4 weeks (P<0.0001), but not with a sustained virological response to therapy. The median viral load at baseline, before therapy, was markedly increased in people with the ‘favourable’ IL28B genotype [median viral load for the TT allele, 925 961 IU ml−1 (range 2200–21 116 965 IU ml−1), and for the GT or GG allele, 260 284 IU ml−1 (range 740–7 560 000 IU ml−1); P = 0.0010]. Our results suggest that the host genetic response plays an important role in early viral clearance of subtype 3a virus from the blood. However, significant reservoirs of infection must persist, as viral relapse is common, even in those with the favourable host genotype.

scholarly journals Significant liver damage in patients with bleeding disorders and chronic hepatitis C: non-invasive assessment of liver fibrosis using transient elastography

2006 ◽  
Vol 5 (1) ◽  
pp. 25-30 ◽  
Author(s):  
D. POSTHOUWER ◽  
E. P. MAUSER-BUNSCHOTEN ◽  
K. FISCHER ◽  
K. J. VAN ERPECUM ◽  
R. J. DE KNEGT
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Transient Elastography ◽  
Bleeding Disorders ◽  
Non Invasive

scholarly journals Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients

Pathogens ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 57
Author(s):  
Momen Askoura ◽  
Hisham A. Abbas ◽  
Hadeel AlSadoun ◽  
Wesam H. Abdulaal ◽  
Amr S. Abu Lila ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Viral Load ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Serum Level ◽  
Viral Infections ◽  
Serum Levels ◽  
Chronic Patients

Hepatitis C virus (HCV) is one of the most epidemic viral infections in the world. Three-quarters of individuals infected with HCV become chronic. As a consequence of persistent inflammation, a considerable percentage of chronic patients progress to liver fibrosis, cirrhosis, and finally hepatocellular carcinoma. Cytokines, which are particularly produced from T-helper cells, play a crucial role in immune protection against HCV and the progression of the disease as well. In this study, the role of interleukins IL-33, IL-17, and IL-25 in HCV patients and progression of disease from chronicity to hepatocellular carcinoma will be characterized in order to use them as biomarkers of disease progression. The serum levels of the tested interleukins were measured in patients suffering from chronic hepatitis C (CHC), hepatocellular carcinoma (HCC), and healthy controls (C), and their levels were correlated to the degree of liver fibrosis, liver fibrosis markers and viral load. In contrast to the IL-25 serum level, which increased in patients suffering from HCC only, the serum levels of both IL-33 and IL-17 increased significantly in those patients suffering from CHC and HCC. In addition, IL-33 serum level was found to increase by liver fibrosis progression and viral load, in contrast to both IL-17 and IL-25. Current results indicate a significant role of IL-33 in liver inflammation and fibrosis progress in CHC, whereas IL-17 and IL-25 may be used as biomarkers for the development of hepatocellular carcinoma.

METABOLISM FEATURES OF HAPTOGLOBIN AS INFLAMMATION ACUTE PHASE PROTEIN IN PATIENTS WITH CHRONIC HCV INFECTION

2020 ◽  
pp. 70-76
Author(s):  
G. O. Solomennyk ◽  
O. Ye. Bondar ◽  
N. V. Antsyferova ◽  
A. V. Gavrylov
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Morphological Changes ◽  
Virus Genotype ◽  
Non Invasive ◽  
Age And Sex

Modern advances in hepatology are characterized by the introduction into practice of interferon−free therapy of chronic hepatitis C, as well as the expansion of the arsenal of methods for non−invasive or minimally invasive diagnosis of morphological changes in the liver. The ineffectiveness of therapy is stipulated by, in particular, the amino acid polymorphism of viral proteins, which determines the resistance of certain variants of HCV to directly acting antiviral drugs. In order to assess the content of haptoglobin in the serum of patients with chronic hepatitis C depending on the activity of cytolytic enzymes in the serum, the degree of inflammatory−necrotic activity of the process, stage of liver fibrosis, virus genotype, viral load, age and sex of patients, prior to, on the background and after antiviral therapy, 215 patients were examined. The results showed that in most patients the content of haptoglobin in the serum was within normal limits. It correlated with the degree of inflammatory−necrotic activity of hepatitis, the stage of liver fibrosis and did not depend on the biochemical activity of the process, virus genotype, viral load, age and sex of the patient. Determining the content of this protein in the serum before the start of combination antiviral therapy, provided that other factors, leading to hypogaptoglobinemia, with a high probability allowed to diagnose severe fibrosis (cirrhosis) of the liver or its absence, and to predict the absence of its effect. On the background of a combined antiviral therapy with ribavirin, there was a decrease in serum haptoglobin, enabling the use of this index to monitor the activity of drug hemolysis and was a reason not to recommend assessment of liver fibrosis by FibroTest during and after treatment, if its protocol included "antiviral Ribavirin". Key words: HCV infection, morphological changes in liver, liver biopsy, non−invasive diagnosis of fibrosis, antiviral therapy, predictors for treatment outcome, haptoglobin.

scholarly journals Liver Damage and Kinetics of Hepatitis C Virus and Human Immunodeficiency Virus Replication during the Early Phases of Combination Antiretroviral Treatment

2000 ◽  
Vol 181 (6) ◽  
pp. 2033-2036 ◽  
Author(s):  
Massimo Puoti ◽  
Francesco Gargiulo ◽  
Eugenia Quiros Roldan ◽  
Alessandro Chiodera ◽  
Loredana Palvarini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Liver Damage ◽  
Antiretroviral Treatment ◽  
Human Immunodeficiency Virus Replication ◽  
Immunodeficiency Virus ◽  
Kinetics Of ◽  
Early Phases

Cryoglobulinemia in chronic liver diseases: Role of hepatitis C virus and liver damage

1994 ◽  
Vol 106 (5) ◽  
pp. 1291-1300 ◽  
Author(s):  
Francoise Lunel ◽  
Lucile Musset ◽  
Patrice Cacoub ◽  
Lionel Frangeul ◽  
Pascale Cresta ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Damage ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases
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