scholarly journals Effects of Timing of Nerve Injury and Repair in Neonatal and Adult Brachial Plexus Injury Models

2021 ◽  
Author(s):  
Grainne Bourke ◽  
Lev Novokov ◽  
Andrew Hart ◽  
Mikael Wiberg

Brachial plexus Injury causes severe and long-term upper limb deficits at any age. The outcome from current reconstructive options depends on the severity of nerve injury and timing of intervention. This chapter summarises the differing biological responses to nerve injury that occur during neonatal, young adult and mature adult life. The central and peripheral reactions to nerve injury, the effects of timing of repair on both motor and sensory neuronal survival and basic science evidence to support early intervention are discussed.

2007 ◽  
Vol 63 (5) ◽  
pp. 1021-1025 ◽  
Author(s):  
Kevin P. Riess ◽  
Thomas H. Cogbill ◽  
Nirav Y. Patel ◽  
Pamela J. Lambert ◽  
Michelle A. Mathiason

2008 ◽  
Vol 1;11 (1;1) ◽  
pp. 81-85
Author(s):  
Silviu Brill

We are presenting a paper on the effectiveness of spinal cord stimulation (SCS) in 2 patients suffering pain from brachial plexus injury (BPI). After a traumatic brachial plexus lesion about 80% of patients develop pain in the deafferentated arm. This pain is considered very resistant to many forms of therapy. In the early 1970s, SCS was introduced in the treatment of BPI pain with disappointing results. There are only about 20 published cases of BPI pain treated with SCS. Many injuries are due to motorcycle accidents, so that patients are often young and require long-term pain relief. During the SCS trial the pain relief was more than 50% with an absolute improvement in the quality of life and significant drug reduction. The results of the SCS were excellent in these 2 patients, defined as more than 50% pain relief at 6 and 18 months. Key words: Spinal cord stimulation, brachial plexus injury, neurophatic pain.


2017 ◽  
Vol 105 ◽  
pp. 623-631 ◽  
Author(s):  
Olga Gutkowska ◽  
Jacek Martynkiewicz ◽  
Sylwia Mizia ◽  
Michał Bąk ◽  
Jerzy Gosk

2014 ◽  
Vol 14 (5) ◽  
pp. 518-526 ◽  
Author(s):  
Scott L. Zuckerman ◽  
Ilyas M. Eli ◽  
Manish N. Shah ◽  
Nadine Bradley ◽  
Christopher M. Stutz ◽  
...  

Object Axillary nerve palsy, isolated or as part of a more complex brachial plexus injury, can have profound effects on upper-extremity function. Radial to axillary nerve neurotization is a useful technique for regaining shoulder abduction with little compromise of other neurological function. A combined experience of this procedure used in children is reviewed. Methods A retrospective review of the authors' experience across 3 tertiary care centers with brachial plexus and peripheral nerve injury in children (younger than 18 years) revealed 7 cases involving patients with axillary nerve injury as part of an overall brachial plexus injury with persistent shoulder abduction deficits. Two surgical approaches to the region were used. Results Four infants (ages 0.6, 0.8, 0.8, and 0.6 years) and 3 older children (ages 8, 15, and 17 years) underwent surgical intervention. No patient had significant shoulder abduction past 15° preoperatively. In 3 cases, additional neurotization was performed in conjunction with the procedure of interest. Two surgical approaches were used: posterior and transaxillary. All patients displayed improvement in shoulder abduction. All were able to activate their deltoid muscle to raise their arm against gravity and 4 of 7 were able to abduct against resistance. The median duration of follow-up was 15 months (range 8 months to 5.9 years). Conclusions Radial to axillary nerve neurotization improved shoulder abduction in this series of patients treated at 3 institutions. While rarely used in children, this neurotization procedure is an excellent option to restore deltoid function in children with brachial plexus injury due to birth or accidental trauma.


2008 ◽  
Vol 33 (4) ◽  
pp. 501-506 ◽  
Author(s):  
J. MCCAUL ◽  
H. SHARMA ◽  
T. E. HEMS

Forty of 136 consecutive patients referred for management of brachial plexus injuries had closed supraclavicular injuries. The results of the initial chest X-rays were available for 29 patients. Nine had avulsion of the C8 and T1 nerve roots from the spinal cord. Eight cases had MR confirmation of lower root avulsion, six of these cases were confirmed surgically and none had any long-term clinical recovery. Twenty had partial brachial plexus injuries without avulsion of these roots. Seven of nine patients with avulsion of C8 and T1 had an extrapleural apical fluid collection. One of these had a fractured first rib. Two of 20 without avulsion had an extrapleural apical fluid collection. Both had fractured the first rib. The difference in incidence of extrapleural apical fluid collection between the two groups, excluding those cases with first rib fractures, was statistically significant. Without a first rib fracture, an ipsilateral extrapleural apical haematoma on a plain chest X-ray of patients with brachial plexus injury strongly suggests pre-ganglionic injury to the lower roots.


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