scholarly journals Smart Drug-Delivery Systems in the Treatment of Rheumatoid Arthritis: Current, Future Perspectives

2021 ◽  
Author(s):  
Largee Biswas ◽  
Vikas Shukla ◽  
Vijay Kumar ◽  
Anita Kamra Verma
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Folate Receptor ◽  
Joint Destruction ◽  
Delivery Systems ◽  
Inflammatory Disorder ◽  
Emerging Trends ◽  
Smart Drug ◽  
Smart Drug Delivery

Rheumatoid arthritis (RA) is a progressive autoimmune inflammatory disorder characterized by cellular infiltration in synovium causing joint destruction and bone erosion. The heterogeneous nature of the disease manifests in different clinical forms, hence treatment of RA still remains obscure. Treatments are limited owing to systemic toxicity by dose-escalation and lack of selectivity. To overcome these limitations, Smart drug delivery systems (SDDS) are under investigation to exploit the arthritic microenvironment either by passive targeting or active targeting to the inflamed joints via folate receptor, CD44, angiogenesis, integrins. This review comprehensively deliberates upon understanding the pathophysiology of RA and role of SDDSs, highlighting the emerging trends for RA nanotherapeutics.

Targeted drug-delivery systems in the treatment of rheumatoid arthritis: recent advancement and clinical status

2020 ◽  
Vol 11 (4) ◽  
pp. 269-284 ◽  
Author(s):  
Srividya Gorantla ◽  
Gautam Singhvi ◽  
Vamshi Krishna Rapalli ◽  
Tejashree Waghule ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Bone Erosion ◽  
Folate Receptor ◽  
Clinical Status ◽  
Joint Destruction ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Systemic Autoimmune Disease

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that is characterized by synovial inflammation, cellular infiltration in joints which leads to progressive joint destruction and bone erosion. RA is associated with many comorbidities including pulmonary disease, rheumatoid nodules and can have a pessimistic impact on quality of life. The current therapies of RA treatment comprise conventional, small molecule and biological antirheumatic drugs. Their utility as therapeutic agents is limited because of poor absorption, rapid metabolism and adverse effects (dose-escalation, systemic toxicity, lack of selectivity and safety). To overcome these limitations, the novel drug delivery systems are being investigated. This review has compiled currently approved therapies along with emerging advanced drug-delivery systems for RA treatment. Further, active targeting of therapeutic agents to inflamed joints via folate receptor, CD44, angiogenesis, integrins and other provided an improved therapeutic efficacy in the treatment of RA.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Smart Drug Delivery Systems

Drug Delivery ◽  
2014 ◽  
pp. 265-316
Author(s):  
Eric P. Holowka ◽  
Sujata K. Bhatia
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Bioceramics: from bone substitutes to nanoparticles for drug delivery

2019 ◽  
Vol 91 (4) ◽  
pp. 687-706 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Bone Repair ◽  
Research Team ◽  
Research Work ◽  
Bone Substitutes ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Since the second half of the 20th century, bioceramics are used for bone repair and regeneration. Inspired by bones and teeth, and aimed at mimicking their structure and composition, several artificial bioceramics were developed for biomedical applications. And nowadays, in the 21st century, with the increasing prominence of nanoscience and nanotechnology, certain bioceramics are being used to build smart drug delivery systems, among other applications. This minireview will mainly describe both tendencies through the research work carried out by the research team of María Vallet-Regí.

Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

Chitosan nanocapsule-mounted cellulose nanofibrils as nanoships for smart drug delivery systems and treatment of avian trichomoniasis

2019 ◽  
Vol 95 ◽  
pp. 290-299 ◽  
Author(s):  
Arash Yunessnia lehi ◽  
Hamidreza Shagholani ◽  
Mohsen Ghorbani ◽  
Ali Nikpay ◽  
Mohammad Soleimani lashkenari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cellulose Nanofibrils ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Stimulus-Responsive Polymeric Nanogels as Smart Drug Delivery Systems

2019 ◽  
Author(s):  
Navid Rabiee ◽  
Sakineh Hajebi ◽  
Mojtaba Bagherzadeh ◽  
Sepideh Ahmadi ◽  
Mohammad Rabiee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimulus Responsive ◽  
Smart Drug ◽  
Smart Drug Delivery
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