Abstract
Background: Secondary bladder tumors are relatively rare in all bladder tumors, while bladder metastases from breast cancer were rarely reported. And interestingly, signet-ring differentiation may appear in metastases from a breast invasive lobular carcinoma regardless of whether or not the primary breast tumor had signet-ring cells, which may cause diagnostic uncertainty.Case presentation: We report a case of a 55-year-old female patient with diffuse bladder thickening as the chief complaint. There was no special clinical manifestation, while cystoscopy showed multiple scattered red protuberances and the biopsy suggested signet-ring-cell carcinoma. Result of gastroscopy suggested poorly differentiated adenocarcinoma with signed-ring cells. Considering the patient's previous history of invasive lobular carcinoma of the breast, chronic myeloid leukemia and metastatic endometrial carcinoma from the breast, we performed the immunohistochemistry and the results indicated that signet-ring-cell carcinomas of the stomach and bladder originated from the breast invasive lobular carcinoma. we performed Positron Emission Tomography/Computed Tomography (PET/CT) and the results showed that there were multiple bone metastases already.Conclusion: This is the first English case report of invasive lobular carcinoma of breast metastasizing to uterus, stomach, bladder and bones with multiple signet-ring-cell variations. We also focus on the Computed Tomography (CT), immunohistochemistry (IHC) and cystoscopy findings and share the clinical diagnosis ideas summarized by this case.
Mutations in Epigenetic Regulation Genes in Gastric Cancer
