scholarly journals A Lower 25(OH)D Level in COVID-19 Patients is Associated with Increased Mortality: An Observational Study

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Seyed Jalal Eshagh Hosseini ◽  
Farzin Davoodi ◽  
Alireza Sharifi ◽  
Zahra Abbasi
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Clinical Findings ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Mean ◽  
D 20

Background: Recent studies have shown that insufficient vitamin D supply is correlated with increase in COVID-19 cases and its mortality. Potentially, it may play an important role in controlling virus proliferation. Objectives: This study aimed to evaluate the association between serum vitamin D levels and clinical findings, and mortality rate in patients with COVID-19. Methods: This cross-sectional study was conducted on 200 COVID-19 patients referred or admitted to Loghman-e-Hakim Hospital of Tehran, Iran, from February to June 2020. After patient selection, demographic information of all patients was recorded. Eventually, the relationship between basic demographic and clinical findings with vitamin D levels in all patients was evaluated. Results: The mean Vit-D levels in intubated and non-intubated patients were 22.95 ± 22.23 ng/mL and 21.64 ± 29.20 ng/mL, respectively (P = 0.018). In most of the outpatients (46.7%), Vit-D levels were between 21 - 30 ng/mL, and 47.6% of admitted patients had Vit-D ≤ 20 ng/mL. The mean Vit-D level in survived patients was significantly higher than patients who died (28.2 ± 21.18 ng/mL vs. 19.91 ± 14.18 ng/mL, respectively; P = 0.021). While 34.2% (55 cases) of survived patients had Vit-D level ≥ 31 ng/mL, about 70% of death cases had Vit-D ≤ 20 ng/mL (P < 0.001). Conclusions: According to our results, vitamin D supplementation could be beneficial in COVID-19 patients. However, further comprehensive clinical trials are needed to confirm these findings.

scholarly journals Vitamin D deficiency in patients with tuberculosis and its correlation with glycemic status

2019 ◽  
Vol 8 (1) ◽  
pp. 239
Author(s):  
Ritu Karoli ◽  
Shobhit Shakya ◽  
Prem Shanker Singh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Glycemic Status ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Patients With Diabetes

Background: Comorbidity of diabetes and tuberculosis has serious health implications. Presence of diabetes at least three times increases the risk of tuberculosis which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels.Aim of the study- Present study was carried out to investigate whether lower serum 25(OH) D might be associated with higher prevalence of pulmonary or extra pulmonary tuberculosis which might provide an evidence for a role of vitamin D in the comorbidity of these two diseases and does it have any correlation with glycemic status.Methods: In a hospital based cross sectional study, 264 patients with newly diagnosed tuberculosis were enrolled and according to glycemic status they were divided into three groups. They were assessed for vitamin D deficiency in addition to routine laboratory and biochemical parameters.Results: The patients with diabetes had significantly lower vitamin D levels. The prevalence of severe vitamin D deficiency was highest in patients who had diabetes with tuberculosis. There was negative correlation between vitamin D levels and Hba1C and extensiveness of pulmonary tuberculosisConclusions: Serum vitamin D levels were significantly lower in tuberculosis patients with pre-diabetes and type 2 diabetes compared with those, who had normal glycemic status. We suggest that there is a need to pay more attention to vitamin D status in this country and if there is coexisting diabetes or impaired glucose intolerance, emphasis on vitamin D supplementation can be of utmost importance.

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

scholarly journals Does Vitamin D Have a Role in the Inception of Childhood Asthma? - A Comparative Cross-Sectional Study

2021 ◽  
Vol 8 (17) ◽  
pp. 1157-1162
Author(s):  
Mohan Jayabal ◽  
Rashmi Ramanathan ◽  
Arun Kumar ◽  
Pavithra Vyshnavi Yogisparan ◽  
Manishankar Subramaniyam ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Function ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Serum Vitamin D ◽  
Vitamin D Levels

BACKGROUND Global prevalence of paediatric asthma has shown a sharp increase in last three decades. Recently vitamin D has been linked with lung function and vitamin D supplementation can lessen the acute exacerbations in asthmatic children. The purpose of the study was to compare lung parameters and vitamin D levels in asthmatic and non-asthmatic children and assess the correlation between vitamin D levels and pulmonary function parameters in children. METHODS A cross-sectional study was conducted among 40 asthmatic children and 42 healthy volunteers between the age group of 5 and 18 years attending the paediatric outpatient department (OPD) in a tertiary care centre in Coimbatore. Pulmonary functions were assessed using computerized spirometer and the serum 25-hydroxy vitamin D levels were estimated by Diazyme EZ vitamin D assay latex enhanced immunoturbidimetric method. The results were compared between asthmatics and non-asthmatics to find out the association. RESULTS The average age of the study participants was 10.5 ± 2.5 years. Lung parameters and mean vitamin D levels are reduced in asthmatics. There is a positive significant correlation between serum vitamin D levels and forced expiratory volume FEV1 / forced vital capacity (FVC) (P < 0.05, r = 0.781), and also between vitamin D and FEV1 (P < 0.05, r = 0.28). Lung parameters like FEV1, FEV1 / FVC ratio and peak expiratory flow rate (PEFR) are significantly decreased in asthmatic children. CONCLUSIONS Majority of the asthmatics have insufficient vitamin D levels than the normal peers with no asthma. Our study confirms the positive association between vitamin D and FEV1 and FEV1 / FVC ratio. KEYWORDS Vitamin D, Asthma, Pulmonary Function, Lung Parameters

scholarly journals Serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study

2020 ◽  
Author(s):  
Qinqiu Wang ◽  
Xiao-ying Shi ◽  
Jinghua Wang ◽  
Juanwen Zhang ◽  
Cheng-Fu Xu
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Obese People ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Lean Nafld ◽  
Low Serum

Abstract Background: Low serum vitamin D concentrations have been reported to be associated with an increased risk of non-alcoholic fatty liver disease (NAFLD). However, whether slim or obese people show a similar association between vitamin D and NAFLD remains speculative. This study aimed to explore the relationship between serum vitamin D concentrations and NAFLD in lean and obese Chinese adults.Methods: This cross-sectional study included 2538 participants (1360 men and 1178 women) who underwent their health checkups at the First Affiliated Hospital of Zhejiang University School of Medicine in 2019. NAFLD was diagnosed by liver ultrasound excluding other causes. The association of serum vitamin D concentrations with NAFLD was analyzed in lean and obese participants.Results: The overall prevalence of NAFLD was 33.61% (13.10% in lean and 53.32% in obese) in this study population. The serum vitamin D levels of obese NAFLD patients were lower than that of the obese NAFLD-free controls. However, the serum vitamin D levels of lean NAFLD patients were comparable to that of the lean NAFLD-free controls. Serum vitamin D levels were negatively correlated with the prevalence of NAFLD in obese but not lean participants. Serum vitamin D levels were independently associated with the risk of NAFLD in obese participants, with an adjusted odd ratio (95% CI) of 0.986 (0.979–0.992). However, the serum vitamin D levels were not related to the risk of NAFLD in lean participants.Conclusions: Low serum vitamin D levels are associated with NAFLD in obese but not lean participants.

scholarly journals Serum vitamin D levels in Berliners of Turkish descent –a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lilian Krist ◽  
Theresa Keller ◽  
Heiko Becher ◽  
Karl-Heinz Jöckel ◽  
Martin Schlaud ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status

2016 ◽  
Vol 30 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Nicole A. Slater ◽  
Michelle L. Rager ◽  
Dawn E. Havrda ◽  
Arthur F. Harralson
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Variant Alleles

This cross-sectional study enrolled 180 patients at a private family practice in Virginia. Total serum vitamin D concentrations were obtained weekly from January 30, 2013, through March 30, 2013, in consecutive patients regularly scheduled for laboratory work at the practice. Patients were categorized into 2 groups and analyzed for variant alleles in vitamin D receptor ( VDR; rs2228570), cytochrome P450 2R1 ( CYP2R1; rs10741657), 7-dehydrocholesterol reductase ( DHCR7; rs12785878), and group-specific component ( GC; rs2282679) to determine whether variants of those alleles influenced total serum 25(OH)D concentrations. One-hundred and eighty patients were enrolled, with 40 (22%) being sufficient, 25-hydroxy vitamin D level 25(OH)D ≥ 30 ng/mL, and 140 (78%) being insufficient, 25(OH)D < 30 ng/mL. Of the 4 genes, 2 genes, CYP2R1 (rs10741657) and GC (rs2282679), demonstrated a significant association related to vitamin D status. Subjects with 1 or more variant alleles at rs10741657 were almost 3.7 (odds ratio [OR] 3.67; 95% confidence interval [CI]: 1.35-9.99) times more likely be insufficient in vitamin D and subjects with 1 or more variant alleles at rs2282679 were about half (OR 0.42; 95% CI: 0.18-0.93) as likely to be insufficient in vitamin D. Allelic variations in CYP2R1 (rs10741657) and GC (rs2282679) affect vitamin D levels, but variant alleles on VDR (rs2228570) and DHCR7 (rs12785878) were not correlated with vitamin D deficiency, 25(OH)D < 30 ng/mL.

scholarly journals Vitamin D status among postmenopausal osteoporotic women: a hospital based cross-sectional study from Northern Sri Lanka.

2020 ◽  
Author(s):  
Navaneethakrishnan Suganthan ◽  
Thirunavukarasu Kumanan ◽  
Vithegi Kesavan ◽  
Mahalingam Aravinthan ◽  
Nadarajah Rajeshkannan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background Vitamin D deficiency is common among post-menopausal women and it is important to treat vitamin D deficiency to prevent falls and fractures in patients with osteoporosis. Few studies examined the prevalence of vitamin D deficiency in general population of Sri Lanka but no studies to date done among post-menopausal women with osteoporosis. This is the first study of such kind conducted to evaluate the serum vitamin D levels and factors related to Vitamin D deficiency among postmenopausal women.Methodology Hospital based Cross -sectional study was conducted at the Endocrine Unit, Teaching Hospital from January to December 2018.During the study period 105 postmenopausal women registered for DEXA scan with Endocrine Unit were recruited to the study. Data collection was done by investigators and blood sample was taken from each participant by registered nursing officers and sample was analysed by using immunohistochemistry assays. Serum Vitamin D levels were categorized and data analysis was done using SPSS 26.Results Mean age of 105 postmenopausal women was 67.7 with minimum 33 and maximum 84 years. Mean Vitamin D levels were 27.5(range11.7-52.5ng/ml). Vitamin D levels were adequate in only 36.2% (95%CI: 27.4-45.7) of women, 44% had insufficient levels and deficiency was present in 19% (95%CI: 12.4-27.4) of participants. Among the 105 women 20% were vegetarian and 53% of them consuming milk on average 3 days per week, 76.2% consuming fish on average 2 days per week, 64.8% consuming egg on average 1 day per week. Furthermore seventy five participants (71.4%) reported adequate level of sun exposure (>30minutes).Commonly reported vitamin deficiency symptoms includes paraesthesia (57.1%),bone pain (55.2%), easy fatigability (54.3%), malaise (51.4%), muscle cramps (43.8%) and proximal myopathy (40.0%).Among 71(66.7%) completed bone density assessment,38% (27.3-49.7) of them showed osteoporosis range. Vertebral Z score showed a significant correlation with vitamin D level(r-0.252, P-0.034).Conclusion Prevalence of vitamin D deficiency is relatively high among the post-menopausal women with a provisional diagnosis of osteoporosis. It is essential to correct vitamin D deficiency with supplementation when initiating treatment for osteoporosis. So vitamin D testing is desirable in decision making to treat or not to treat.

scholarly journals Serum vitamin D levels and alopecia areata: A comparative cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-4
Author(s):  
Blessen B. Dasankunju ◽  
Pradeep S. Nair ◽  
Anuja Elizabeth George
Keyword(s):  
Vitamin D ◽  
Alopecia Areata ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Small Sample ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Age And Sex

Objectives: To determine the relation between serum vitamin D levels and alopecia areata. Materials and Methods: This cross-sectional study included patients with AA who were above 12 years of age and age- and sex-matched controls who attended the dermatology department of a tertiary care center during a period of 1 year. Serum Vitamin D level was determined in each participant. Serum Vitamin D levels documented in both groups were compared. Results: Thirty patients and 30 age- and sex-matched controls constituted the study population. The male-to-female ratio was 1.7:1. Most of the patients (9/30, 30%) were in the age group of 31–40 years. We observed patchy AA in 17 patients (56.7%). Nail involvement was seen in 9 patients (30%). Serum vitamin D levels were insufficient/deficient in 16 patients (53.3%), while in the age- and sex-matched comparison group, vitamin D was insufficient / deficient in 7 cases (23.3%). The difference was statistically significant (P = 0.03). No significant relation was noted either between serum vitamin D levels and number of alopecia lesions or between serum vitamin D levels and the clinical pattern of AA. No significant difference was noted in the vitamin D levels between patients who had involvement of only scalp and those who showed involvement of other body sites. Limitations: Small sample size was the major limitation of the study. Conclusion: Low serum vitamin D levels were more frequent in patients with AA in comparison to healthy controls.

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