scholarly journals Predictive Power of Preoperative Serum Total Bilirubin for the Outcomes Following Pancreaticoduodenectomy

2020 ◽  
Vol 13 (11) ◽  
Author(s):  
Sara Saeidi Shahri ◽  
Mohsen Aliakbarian ◽  
Lida Jarahi
Keyword(s):  
Logistic Regression ◽  
Bilirubin Level ◽  
Biliary Drainage ◽  
Predictive Power ◽  
Total Bilirubin ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Significant Variable ◽  
Preoperative Serum ◽  
Significant Difference

Background: The high levels of bilirubin in patients with periampullary cancers may increase the morbidity or mortality after curative surgery. Objectives: We aimed at evaluating the predictive power of preoperative serum total bilirubin for the outcomes after pancreaticoduodenectomy (PD) in resectable periampullary cancers. Methods: The data of 80 patients, who had undergone PD, were retrospectively analyzed. Regarding the preoperative bilirubin, we opted for 20 mg/dL as the cut-off value to divide patients into two groups to be subjected to simple and multiple logistic regression. Results: A total of 80 patients with a mean age of 54.90 ± 14.33 years underwent PD. The median preoperative bilirubin level was 4.7 mg/dL and the majority of cases (88.8%) had bilirubin < 20 mg/dL. While there was no significant difference in the mortality between bilirubin groups (P = 0.266), bilirubin≥20 mg/dL remarkably increased the postoperative morbidity (P = 0.012, Odds ratio = 3.04); 57.5% of cases underwent biliary drainage before surgery, which did not impact the mortality and morbidity. Multiple analysis by a logistic regression model disclosed that the only statistically significant variable for mortality was the total operative time (P = 0.038) and among all factors, total bilirubin level was the only independent predictor for the morbidity status (P = 0.009). Conclusions: This study suggested that preoperative biliary drainage should only be limited to patients with high bilirubin levels (≥ 20 mg/dL) or expected delayed surgeries.

scholarly journals Role of serum bilirubin as a marker of acute gangrenous appendicitis

2012 ◽  
Vol 1 (2) ◽  
pp. 89-92 ◽  
Author(s):  
P Ghimire ◽  
P Thapa ◽  
N Yogi ◽  
P Ghimire
Keyword(s):  
Logistic Regression ◽  
Leucocyte Count ◽  
Total Bilirubin ◽  
Serum Bilirubin ◽  
Total Bilirubin Level ◽  
Total Serum ◽  
Total Leucocyte Count ◽  
Serum Total Bilirubin ◽  
Gangrenous Appendicitis ◽  
Significant Difference

Background: This study has compared the difference in serum bilirubin between patients with gangrenous and non-gangrenous appendicitis. Methods: A prospective analytical study of, 141 patients who underwent appendectomy, from March 2010 to March 2011 in Manipal Teaching Hospital, Pokhara, Nepal was carried out. Clinico-demographic data, Alvarado’s score, total serum bilirubin, total leucocyte count and histopathological report of all the cases were collected in a prestructured proforma. Comparison between gangrenous and non-gangrenous appendicitis groups was carried out using independent sample t test, Chisquare test, and direct logistic regression. The data was analyzed using SPSS 11.6 software. Result: Around 43% (61 out of 141) patients had gangrenous appendicitis and statistically significant difference was found between the two groups in total Alvarado’s score, total count and total bilirubin level. The effect size as indicated by eta square statistics was large for total bilirubin (eta squared=0.39) as compared to total Alvarado’s score (0.09) and total leucocyte count (0.05). Direct logistic regression model showed serum total bilirubin as the only independent variable to make a unique statistically significant contribution in predicting gangrenous appendicitis. Conclusion: Pre-operative assessment of serum total bilirubin can serve as an important maker of acute gangrenous appendicitis. DOI: http://dx.doi.org/10.3126/njms.v1i2.6606 Nepal Journal of Medical Sciences. 2012;1(2): 89-92

Pre-treatment serum total bilirubin level as an indicator of optimal CPT-11 dosage

2014 ◽  
Vol 75 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Katsuya Makihara ◽  
Sayaka Azuma ◽  
Nobuyuki Kawato ◽  
Hiroyuki Ueno ◽  
Izumi Nakata
Keyword(s):  
Bilirubin Level ◽  
Total Bilirubin ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Pre Treatment

Association between serum total bilirubin level and leukoaraiosis in Korean adults

2012 ◽  
Vol 45 (4-5) ◽  
pp. 289-292 ◽  
Author(s):  
Byoung-Jin Park ◽  
Jae-Yong Shim ◽  
Hye-Ree Lee ◽  
Hee-Taik Kang ◽  
Jung-Hyun Lee ◽  
...  
Keyword(s):  
Bilirubin Level ◽  
Total Bilirubin ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Korean Adults

scholarly journals SERUM TOTAL BILIRUBIN, NOT CHOLELITHIASIS, IS INFLUENCED BY UGT1A1 POLYMORPHISM, ALPHA THALASSEMIA AND S GENOTYPE: FIRST REPORT ON COMPARISON BETWEEN ARAB-INDIAN AND AFRICAN S GENES

2015 ◽  
Vol 7 ◽  
pp. e2015060 ◽  
Author(s):  
Said Y ALkindi ◽  
Anil Pathare ◽  
Salam Alkindi
Keyword(s):  
Steady State ◽  
Bilirubin Level ◽  
Total Bilirubin ◽  
Globin Gene ◽  
Total Bilirubin Level ◽  
Promoter Polymorphism ◽  
Serum Total Bilirubin ◽  
Imaging Data ◽  
Ugt1a1 Polymorphism ◽  
The Mean

Background: We explored the potential relationship between steady state serum bilirubin levels and the incidence of cholelithiasis in the context of UGT1A1 gene A(TA)nTAA promoter polymorphism in Omani sickle cell anemia (SCA) patients, homozygotes for African (Benin and Bantu) and Arab-Indian bS haplotypes, but sharing the same microgeographical environment and comparable life style factors. Methods: 136 SCA patients were retrospectively studied in whom imaging data including abdominal CT scan, MRI or Ultrasonography was routinely available. Available data on the mean steady state hematological/biochemical parameters (n=136),  bs haplotypes(n=136), a globin gene status (n=105) and UGT1A1 genotypes(n=133) were reviewed from the respective medical records. Results: The mean serum total bilirubin level was significantly higher in the homozygous UGT1A1(AT)7 group as compared to  UGT1A1(AT)6 group. Strikingly, cholelithiasis was not influenced by age, gender, alpha globin genotype or bS haplotypes in this SCA cohort. Conclusion: As observed in other population groups, the UGT1A1 (AT)7 homozygosity was significantly associated with raised serum total bilirubin level, but the prevalence of gallstones in the Omani SCA patients was not associated with a thalassaemia, UGT1A1 polymorphism, or bs haplotypes. 

The Association Between Heterozygosity forUGT1A1*6,UGT1A1*28, and Variation in the Serum Total-Bilirubin Level in Healthy Young Japanese Adults

2013 ◽  
Vol 17 (6) ◽  
pp. 464-469 ◽  
Author(s):  
Hiroyuki Moriya ◽  
Katsuhiko Saito ◽  
Nuala Helsby ◽  
Shigekazu Sugino ◽  
Michiaki Yamakage ◽  
...  
Keyword(s):  
Bilirubin Level ◽  
Total Bilirubin ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Japanese Adults

scholarly journals Risk Factors for Prognosis after the Maze IV Procedure in Patients with Atrial Fibrillation Undergoing Valve Surgery

2021 ◽  
Author(s):  
Shenghua Zhou
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Bilirubin Level ◽  
Right Atrium ◽  
Total Bilirubin ◽  
Elevated Serum ◽  
Total Bilirubin Level ◽  
Valve Surgery ◽  
Serum Total Bilirubin

The present study evaluated risk factors related to persistent atrial fibrillation (AF) at discharge (AF-d) and recurrentatrial fibrillation (rAF) and all-cause death after the maze IV procedure. Two hundred nineteen patients (63 female,aged 52.5 ± 8.8 years) with valve disease and persistent AF undergoing valve surgery and the maze IV procedure in our center between 2015 and 2016 were included. Baseline demographic and clinical data were obtained by review of medical records. The median follow-up period was 27 months (interquartile range 21–34 months) in our patient cohort.The primary end point was all-cause death. The secondary end point was AF-d or rAF. rAF is defined as AF recurrenceat 3 months or later after the procedure. Twenty-eight patients (12.8%) died during follow-up. Multiple logistic regression analysis showed that thrombocytopenia, elevated serum total bilirubin level, a larger right atrium, AF-d, and rAF were independent determinants for all-cause death after the maze IV procedure after adjustment for age, sex, and clinical covariates, including New York Heart Association class III/IV disease, hypertension, and aortic regurgitation, while valvular disease duration and left atrial diameter greater than 80.5 mm were independent determinants for AF-d, and thrombocytopenia, elevated serum total bilirubin level, higher mean pulmonary artery pressure, and AF-d were independent predictors for rAF. In conclusion, thrombocytopenia, elevated serum total bilirubin level, an enlarged right atrium, AF-d, and rAF are independent predictors of all-cause death in patients undergoing the maze IV procedure.

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