Diagnostic Value of Carotid Artery Intima-media Thickness in Patients with Type 2 Diabetes and its Correlation with HbA1c Levels

Objectives: This study aimed to assess the role of carotid ultrasonography and measure the carotid artery intima-media thickness (CIMT) and its correlation with hemoglobin A1c (HbA1c) to observe cardiovascular disease (CVD) risks in patients with type 2 diabetes mellitus (T2DM). Methods: In this observational study, 205 consecutive patients with T2DM from Golestan Hospital, Ahvaz, Iran, were included. We performed HbA1c measurements using high-pressure liquid chromatography (HPLC) with a thermo-system. Carotid arteries ultrasonography was performed with an Aloka SSD 5500 apparatus with a 7.5 MHz transducer. The CIMT was measured in the supine position with a slight neck extension. Results: There was no statistically significant difference between the two study groups in the duration of diabetes with CIMT (P = 0.425), while the differences in creatinine, HbA1c, and urine albumin were statistically significant (P = 0.020, P = 0.041, and P = 0.016, respectively). There was no correlation between CIMT and age (r = 0.19, P = 0.792) and duration of diabetes (r = 0.125, P = 0.081). Furthermore, there was no remarkable association between CIMT and weight (r = 0.12, P = 0.881) and FBS ( r = 0.062, P = 0.405). There was also a non-significant negative correlation between HbA1c% and CIMT (r = -0.127, P = 0.127). Conclusions: Ultrasound measurement of CIMT is a safe and relatively cost-effective way of diagnosing atherosclerosis. Thus, the ultrasound's predictive value as a safe and non-invasive examination may alert the related field experts early enough to intervene to prevent major cardiovascular complications.

Download Full-text

Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Therapeutic Advances in Chronic Disease ◽

10.1177/20406223211026993 ◽

2021 ◽

Vol 12 ◽

pp. 204062232110269

Author(s):

Yipin Zhao ◽

Huawei Wang ◽

Dazhi Ke ◽

Wei Deng ◽

Yingying Ji ◽

...

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Conventional Therapy ◽

Therapy Group ◽

Controlled Trial ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

Significant Difference

Background and Aims: Studies have shown that dipeptidyl peptidase-4 (DDP-4) inhibitors have anti-atherosclerotic effects. However, in the PROLOGUE study, sitagliptin failed to slow the progression of carotid intima-media thickness (CIMT) relative to conventional therapy. We conducted a post hoc analysis of the PROLOGUE study and compared the effects of sitagliptin and conventional therapy on changes in CIMT in subgroups with or without hyperuricemia. Methods: The PROLOGUE study was a randomized controlled trial of 442 patients with type 2 diabetes mellitus (T2DM). Patients were randomized to receive sitagliptin added therapy or conventional therapy. Based on the serum uric acid levels of all study populations in the PROLOGUE study, we divided them into hyperuricemia subgroup ( n = 104) and non-hyperuricemia subgroup ( n = 331). The primary outcome was changed in carotid intima-media thickness (CIMT) parameters compared with baseline during the 24 months treatment period. Results: In the hyperuricemia subgroup, compared with the conventional therapy group, the changes in the mean internal carotid artery (ICA)-IMT and max ICA-IMT at 24 months were significantly lower in the sitagliptin group [−0.233 mm, 95% confidence interval (CI) (−0.419 to 0.046), p = 0.015 and −0.325 mm, 95% CI (−0.583 to −0.068), p = 0.014], although there was no significant difference in the common carotid artery CIMT. Conclusion: The results of our analysis indicated that sitagliptin attenuated the progression of CIMT than conventional therapy in T2DM and hyperuricemia patients.

Download Full-text

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

World Journal of Diabetes ◽

10.4239/wjd.v8.i1.18 ◽

2017 ◽

Vol 8 (1) ◽

pp. 18

Author(s):

Kristina S Petersen ◽

Jennifer B Keogh ◽

Peter J Meikle ◽

Manohar L Garg ◽

Peter M Clifton

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Common Carotid Artery ◽

Intima Media Thickness ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Media Thickness

Download Full-text

Relationship Between Postprandial Triglyceride Level and Intima-Media Thickness of Carotid Artery after Troglitazone Treatment in Type 2 Diabetes

Lipoprotein Metabolism and Atherogenesis ◽

10.1007/978-4-431-68424-4_34 ◽

2000 ◽

pp. 154-156

Author(s):

Hiroyuki Koshiyama ◽

Satsuki Tanaka ◽

Jun Minamikawa ◽

Kazuwa Nakao

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Triglyceride Level ◽

Intima Media Thickness ◽

Media Thickness ◽

Postprandial Triglyceride

Download Full-text

Alpha-tocopherol concentrations correlate with carotid artery intima-media thickness in type 2 diabetes

Atherosclerosis ◽

10.1016/j.atherosclerosis.2020.10.840 ◽

2020 ◽

Vol 315 ◽

pp. e266

Author(s):

R. Dalan ◽

C.J. Lim ◽

B.O. Boehm

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Intima Media Thickness ◽

Alpha Tocopherol ◽

Media Thickness

Download Full-text

The relationship between the level of mean platelet volume and the carotid artery intima-media thickness in patients with type 2 diabetes mellitus

International Journal of Diabetes in Developing Countries ◽

10.1007/s13410-015-0426-9 ◽

2015 ◽

Vol 37 (2) ◽

pp. 137-140

Author(s):

Hong-xia Wan ◽

Lan Zhang ◽

Tong-ning Yi ◽

Li-dong Zhang

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Carotid Artery ◽

Mean Platelet Volume ◽

Intima Media Thickness ◽

Platelet Volume ◽

Media Thickness ◽

The Relationship

Download Full-text

High neutrophil-to-lymphocyte ratio is associated with increased carotid artery intima-media thickness in type 2 diabetes

Journal of Diabetes Investigation ◽

10.1111/jdi.12541 ◽

2016 ◽

Vol 8 (1) ◽

pp. 101-107 ◽

Cited By ~ 8

Author(s):

Xueqin Li ◽

Jun Shen ◽

Zhenghong Lu ◽

Min Chen ◽

Xiaozheng Fang ◽

...

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Intima Media Thickness ◽

Neutrophil To Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Media Thickness

Download Full-text

Cardiorespiratory Fitness and Carotid Artery Intima Media Thickness in Men With Type 2 Diabetes

Journal of Physical Activity and Health ◽

10.1123/jpah.9.4.549 ◽

2012 ◽

Vol 9 (4) ◽

pp. 549-553 ◽

Cited By ~ 8

Author(s):

Sae Young Jae ◽

Kevin Heffernan ◽

Bo Fernhall ◽

Yoon-Ho Choi

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Cardiorespiratory Fitness ◽

Carotid Atherosclerosis ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Peak Oxygen Uptake ◽

Media Thickness ◽

Multivariable Regression

Background:We tested the hypothesis that higher levels of cardiorespiratory fitness are inversely associated with carotid artery intima media thickness in 746 (age 53 ± 7 yrs) men with type 2 diabetes.Methods:We measured common carotid intima media thickness and defined carotid atherosclerosis as a carotid intima media thickness > 1.0 mm. Cardiorespiratory fitness was directly measured by peak oxygen uptake using expired gases analysis during a standard treadmill test.Results:Cardiorespiratory fitness was independently associated with common carotid intima media thickness in multivariable regression (β = –0.15, P < .05). After adjusting for established risk factors, high and moderate cardiorespiratory fitness were associated with lower odds ratios for having carotid atherosclerosis—0.49 (95% CI, 0.30–0.81), and 0.59 (95% CI, 0.38–0.92), respectively—as compared with low cardiorespiratory fitness. Each 1 metabolic equivalent increment higher cardiorespiratory fitness was associated with 27% (OR = 0.73; 95% CI, 0.61–0.87) lower prevalence of carotid atherosclerosis.Conclusions:These results suggest that high cardiorespiratory fitness is inversely associated with common carotid intima media thickness in men with type 2 diabetes.

Download Full-text