scholarly journals Effects of a Combination of Foeniculum vulgare, Melissa officinalis Extract, and Nigella saliva Powder on Healthy Menopausal Women with Sexual Dysfunction: A Randomized Clinical Trial

2020 ◽  
Vol 15 (3) ◽  
Author(s):  
Shima Afshar ◽  
Fariba Afshar ◽  
Amir Rezazade ◽  
Zeinab Shaker Ardakani ◽  
Zahra Jafari Azar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Nigella Sativa ◽  
Melissa Officinalis ◽  
Foeniculum Vulgare ◽  
Menopausal Women ◽  
Nigella Sativa Seed

Background: Menopause is a critical period with frequent sexual disorders. Objectives: The current study assessed the therapeutic effect of a combination of the aerial part of Melissa officinalis, fennel fruit extract, and Nigella sativa seed powder on the sexual dysfunction of postmenopausal women. Methods: This randomized clinical trial was performed on 48 menopausal women from April 2015 to October 2017. The participants included the menopausal women referring to the clinic of Gorgan health centers aged between 41 and 54 years with natural menopause (amenorrhea for at least 12 months) and discomfort in sexual activity. They were randomized into two treatment groups. Group 1 (n = 27) received 1000 mg capsules (Melissa officinalis, fennel extract, and Nigella sativa powder), and group 2 (n = 21) received a placebo (1000 mg starch capsules (in an eight-week course of treatment (one capsule per day for each group). The variables in the female sexual function index (FSFI) questionnaire were compared in the two groups before and after the intervention. Results: The results showed that the mean scores of sexual dysfunction in the domains of arousal, lubrication, orgasm, satisfaction, and pain were not significantly different between the two groups (P > 0.05). Conclusions: Despite many studies on the effectiveness of Melissa, Foenculum, and Nigella, this study showed that a combination of Foeniculum vulgare, Melissa officinalis extract, and Nigella sativa seed powder does not improve the sexual function of postmenopausal women with sexual dysfunction, and it might be the synergism effect of this combination.

scholarly journals The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial

2021 ◽  
Author(s):  
Mahboobeh Shirazi ◽  
Mohamad Naser Jalalian ◽  
Masoumeh Abed ◽  
Marjan Ghaemi
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Sleep Disturbance ◽  
Postmenopausal Women ◽  
Melissa Officinalis ◽  
Foeniculum Vulgare ◽  
Double Blind ◽  
Menopausal Women ◽  
The Mean

Abstract Objective The present study aimed to assess the effect of Melissa Officinalis L. (a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance. Methods The present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive M. Officinalis L. (500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups. Results The mean for all MENQOL domain scores were significantly improved in the M. Officinalis L. group compared with citalopram and placebo (p < 0.001). The mean ± standard deviation (SD) after 8 weeks in the M. Officinalis L., citalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor (p < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social (p < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively. Conclusions The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance. Trial registration The present study was registered by the name “Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders” with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT).

Effects of Sex Education and Kegel Exercises on the Sexual Function of Postmenopausal Women: A Randomized Clinical Trial

2017 ◽  
Vol 14 (7) ◽  
pp. 959-967 ◽  
Author(s):  
Soheila Nazarpour ◽  
Masoumeh Simbar ◽  
Fahimeh Ramezani Tehrani ◽  
Hamid Alavi Majd
Keyword(s):  
Clinical Trial ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Sex Education ◽  
Kegel Exercises

scholarly journals Prevalence and associated risk factors for sexual dysfunction among postmenopausal women: a study from Iran

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Azadeh Tavoli ◽  
Zahra Tavoli ◽  
Mohammad Effatpanah ◽  
Ali Montazeri
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Postmenopausal Women ◽  
Anxiety And Depression ◽  
Contributing Factors ◽  
Convenience Sample ◽  
Factors Associated ◽  
Sexual Frequency ◽  
Menopausal Women ◽  
The Relationship

Abstract Background Female Sexual Dysfunction (FSD) is a distressing condition linked to menopause. This study aimed to determine the prevalence and contributing factors for FSD among postmenopausal women. Methods This was a cross-sectional study. A convenience sample of postmenopausal women attending a gynecology clinic in a teaching hospital affiliated with Tehran University of Medical Sciences was enrolled into the study. The Female Sexual Function Index (FSFI) was used to assess sexual function. In addition, demographic and psychosocial information were recorded. The association between sexual function and anxiety and depression were examined to explore the data. Results In all 162 postmenopausal women were studied. We performed general linear regression analysis to assess the relationship between sexual function and anxiety while including demographic variables in the model. The results showed that the model could explain about 46% of the variance observed in sexual function (adjusted R2 = 0.467). The analysis indicated that among independent variables, age (p <  0.001), sexual frequency (p <  0.001), and anxiety (p = 0.003) were significant contributing factors associated with sexual function. A similar analysis evaluating the relationship between sexual function and depression in menopausal women found that age (p <  0.001), sexual frequency (p <  0.001), and depression (p = 0.003), were significant contributing factors associated with sexual function; explaining about 46% of the variance observed (adjusted R2 = 0.466). Conclusion The findings showed that nearly half of menopausal women had sexual dysfunction in this convenience sample of women seeking gynecologic care. Women reporting sexual dysfunction also reported a higher prevalence of anxiety and depression. Indeed, recognition of such factors requires a holistic therapeutic approach to sexual dysfunction among postmenopausal women.

The effect of Cornus mas extract consumption on bone biomarkers and inflammation in postmenopausal women: A randomized clinical trial

2021 ◽  
Author(s):  
Naheed Aryaeian ◽  
Fatemehsadat Amiri ◽  
Seyedeh Tayebeh Rahideh ◽  
Jamileh Abolghasemi ◽  
Shima Jazayeri ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Bone Biomarkers ◽  
Cornus Mas

Effect of Vaginal Stretching and Photobiomodulation Therapy on Sexual Function in Women With Pelvic Floor Myofascial Pain - A Randomized Clinical Trial

2022 ◽  
Vol 19 (1) ◽  
pp. 98-105
Author(s):  
Claudia Pignatti Frederice ◽  
Ticiana Aparecida Alves de Mira ◽  
Helymar Costa Machado ◽  
Luiz Gustavo Oliveira Brito ◽  
Cássia R.T. Juliato
Keyword(s):  
Clinical Trial ◽  
Sexual Function ◽  
Pelvic Floor ◽  
Randomized Clinical Trial ◽  
Myofascial Pain ◽  
Photobiomodulation Therapy

Randomized clinical trial of tamoxifen alone or combined with fluoxymesterone in postmenopausal women with metastatic breast cancer.

1988 ◽  
Vol 6 (5) ◽  
pp. 825-831 ◽  
Author(s):  
J N Ingle ◽  
D I Twito ◽  
D J Schaid ◽  
S A Cullinan ◽  
J E Krook ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Metastatic Breast Cancer ◽  
Side Effects ◽  
Postmenopausal Women ◽  
Randomized Clinical Trial ◽  
Statistical Significance ◽  
Metastatic Breast ◽  
Rank Test ◽  
Breast Cancer Patients

A randomized clinical trial was performed to determine if combination hormonal therapy with tamoxifen (TAM) and fluoxymesterone (FLU) was more efficacious than TAM alone for the treatment of postmenopausal women with metastatic breast cancer. Patients failing TAM could subsequently receive FLU. The dose of both drugs was 10 mg orally twice daily. Objective responses were seen in 50 of 119 TAM patients (42%) and 63 of 119 TAM plus FLU patients (53%) (one-sided P = .05). Time to disease progression distributions were better for TAM plus FLU (median, 350 days v 199 days), but the log rank test only approached statistical significance (one-sided P = .07). Duration of response and survival distributions were similar between the two treatment arms. Toxicities, in terms of androgenic side effects, were greater on the TAM plus FLU regimen. Fifty-two patients are evaluable for response with FLU following TAM and 21 (40%) have achieved a response. We conclude that the advantages in terms of response rate and time to progression observed with TAM plus FLU probably represent a biological effect, but are not of sufficient magnitude to justify the routine clinical use of this combination given the lack of survival advantage and side effects encountered.

Radiofrequency in female external genital cosmetics and sexual function: a randomized clinical trial

2016 ◽  
Vol 27 (11) ◽  
pp. 1681-1687 ◽  
Author(s):  
Patrícia Lordêlo ◽  
Mariana Robatto Dantas Leal ◽  
Cristina Aires Brasil ◽  
Juliana Menezes Santos ◽  
Maria Clara Neves Pavie Cardoso Lima ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Sexual Function ◽  
Randomized Clinical Trial
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