scholarly journals Observational Studies in Bariatric Surgery

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Fatemeh Sadat Hosseini-Baharanchi
Keyword(s):  
Bariatric Surgery ◽  
Observational Studies

scholarly journals Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

2013 ◽  
Vol 169 (6) ◽  
pp. 829-834 ◽  
Author(s):  
Maria T Vamvini ◽  
Konstantinos N Aronis ◽  
Grigorios Panagiotou ◽  
Joo Young Huh ◽  
John P Chamberland ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Observational Studies ◽  
Activin A ◽  
Morbidly Obese ◽  
Serum Samples ◽  
Tissue Samples ◽  
Endocrine Organ ◽  
Obese Subjects ◽  
And Function ◽  
Circulating Levels

ObjectiveSkeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology and function exhibit similarities with the functions of the FST–MSTN–activin A axis. It remains unknown whether there is any interplay among these molecules. The aim of this study is to examine potential associations of irisin with the FST, MSTN, and activin A axis.MethodsTwo observational studies were performed to evaluate the associations of irisin with the other three peptides. Study A included 150 healthy males aged 18.48±0.16 years with BMI 23.18±3.75 kg/m2. Fasting serum samples were used to measure the levels of the molecules of interest. Study B included 14 morbidly obese individuals, candidates for bariatric surgery, aged 53.14±8.93 years with BMI 50.18±10.63 kg/m2. Blood samples were obtained after an overnight fast. Eight out of the 14 participants consented to an optional thigh biopsy during their bariatric surgery. Using the above blood and tissue samples, we measured circulating levels and muscle mRNA of irisin, FST, MSTN, and activin A.ResultsWe report that FNDC5 mRNA in muscle is positively correlated with FST mRNA expression in morbidly obese subjects (ρ=0.93, P<0.001). We also found that circulating irisin is positively correlated with FST circulating levels among lean subjects (ρ=0.17, P=0.05) while this association was suggestive among the obese (ρ=0.56, P=0.07).ConclusionThe newly identified myokine irisin may be positively associated with FST at both the mRNA and circulating protein level.

scholarly journals The Formidable yet Unresolved Interplay between Endometriosis and Obesity

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Athanasios Pantelis ◽  
Nikolaos Machairiotis ◽  
Dimitris P. Lapatsanis
Keyword(s):  
Bariatric Surgery ◽  
Genetic Background ◽  
Observational Studies ◽  
Multidisciplinary Approach ◽  
Inverse Correlation ◽  
Experimental Models ◽  
Future Research ◽  
Body Adiposity ◽  
Low Body Mass Index ◽  
Exact Relationship

Obesity and endometriosis are two very common entities, yet there is uncertainty on their exact relationship. Observational studies have repeatedly shown an inverse correlation between endometriosis and a low body mass index (BMI). However, obesity does not protect against endometriosis and on the contrary an increased BMI may lead to more severe forms of the disease. Besides, BMI is not accurate in all cases of obesity. Consequently, other anthropometric and phenomic traits have been studied, including body adiposity content, as well as the effect of BMI early in life on the manifestation of endometriosis in adulthood. Some studies have shown that the phenotypic inverse correlation between the two entities has a genetic background; however, others have indicated that certain polymorphisms are linked with endometriosis in females with increased BMI. The advent of metabolic bariatric surgery and pertinent research have led to the emergence of biomolecules that may be pivotal in understanding the pathophysiological interaction of the two entities, especially in the context of angiogenesis and inflammation. Future research should focus on three objectives: detection and interpretation of obesity-related biomarkers in experimental models with endometriosis; integration of endometriosis-related queries into bariatric registries; and multidisciplinary approach and collaboration among specialists.

scholarly journals Bariatric surgery as a safe and effective intervention for the control of comorbidities in older adults

2020 ◽  
Vol 14 (3) ◽  
pp. 207-212
Author(s):  
Juliana Bento da Cunha ◽  
Maria Clara Pereira Fialho ◽  
Sergio Lincoln de Matos Arruda ◽  
Otávio Toledo Nóbrega ◽  
Einstein Francisco Camargos
Keyword(s):  
Bariatric Surgery ◽  
Older Adults ◽  
Older Adult ◽  
Observational Studies ◽  
Sleep Apnea Syndrome ◽  
Frailty Syndrome ◽  
Risk Of Falls ◽  
Apnea Syndrome ◽  
Remission Of Comorbidities ◽  
Low Rate

INTRODUCTION: In addition to being associated with worsening of diseases related to metabolic syndrome and musculoskeletal disorders, obesity in older adults increases the risk of falls, frailty syndrome, depression, and dementia, with consequent functional loss. Among all treatments available, bariatric surgery is an option for eligible patients. OBJECTIVES: To discuss aspects related to the safety and benefits of bariatric surgery for the control or remission of comorbidities in older adults. METHODS: This literature review was carried out in databases, using the following keywords: bariatric surgery and elderly or aged or older adult and comorbidities or safety. We included clinical trials, observational studies, comparative studies, and reviews that evaluated the effect of bariatric surgery on the control or remission of comorbidities in older adults. RESULTS: In recent years, several studies have evidenced not only control or remission of comorbidities, such as diabetes, hypertension, and sleep apnea syndrome, but also a low rate of complications, similar to those observed in young people. CONCLUSIONS: Based on the results of these studies, bariatric surgical procedures can be indicated for eligible older adults, without age restriction, taking into account functional and life expectancy aspects.

Impact of bariatric surgery on renal functions in patients with type 2 diabetes: systematic review of randomized trials and observational studies

2016 ◽  
Vol 12 (10) ◽  
pp. 1873-1882 ◽  
Author(s):  
Xu Zhou ◽  
Ling Li ◽  
Joey S.W. Kwong ◽  
Jiajie Yu ◽  
Youping Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Observational Studies ◽  
Randomized Trials ◽  
Renal Functions

scholarly journals Hypovitaminosis D in bariatric surgery: A systematic review of observational studies

Metabolism ◽  
2016 ◽  
Vol 65 (4) ◽  
pp. 574-585 ◽  
Author(s):  
Marlene Toufic Chakhtoura ◽  
Nancy N. Nakhoul ◽  
Khaled Shawwa ◽  
Christos Mantzoros ◽  
Ghada A. El Hajj Fuleihan
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Observational Studies ◽  
Hypovitaminosis D

scholarly journals 1701 A Systematic Review of The Use of Stents in The Treatment of Bariatric Surgery Complications

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
O Barbouti ◽  
J Wei
Keyword(s):  
Bariatric Surgery ◽  
Observational Studies ◽  
Stent Migration ◽  
Success For All ◽  
Metal Stents ◽  
Surgery Complications ◽  
Endoscopic Stents ◽  
Bariatric Surgery Complications ◽  
Bariatric Complications ◽  
Self Expanding Metal Stents

Abstract 41 retrospective observational studies were identified of 792 obese and super obese patients treated with endoscopic stents for bariatric surgery complications including leaks (n = 770) and strictures (n = 22) post-Roux en Y gastric bypass (n = 228) and sleeve gastrectomy (n = 534). The main outcomes of the studies were the percentage success of stent therapy and percentage stent migration. Stents included self-expanding metal stents (SEMS), including partially covered self-expanding metal stents (PcSEMS) and fully covered self-expanding metal stents (FcSEMS). Several SEMS used were specifically designed for bariatric complications, being larger in diameter to reduce migration. The pooled percentage success for all patients (SG and RYGB) was 80.81% with stent migration occurring in 24.67% in all groups. The pooled percentage success for the RYGB group was 80.28% and in the LSG group was 85.86% with percentage migration occurring in 20.65% and 23.82% respectfully.

scholarly journals Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Froukje W. Koremans ◽  
Xiaolong Chen ◽  
Abhirup Das ◽  
Ashish D Diwan
Keyword(s):  
Bariatric Surgery ◽  
Back Pain ◽  
Observational Studies ◽  
Meta Analysis ◽  
Underlying Mechanism ◽  
Morbidly Obese ◽  
Low Grade ◽  
Obese Patients ◽  
Eligibility Criteria ◽  
Pain Scores

Objective: To evaluate if back pain scores in morbidly obese patients change after bariatric surgery. Summary Background Data: Obese patients often complain of low back pain (LBP), however the underlying mechanism is not fully understood. Recent research shows that, next to mechanical loading, the chronic low-grade inflammation that arises in obese patients is contributing to LBP due to intervertebral disc degeneration. Therefore, it is hypothesized that bariatric surgery will have an effect on the LBP in obese patients. Methods: We searched four online databases for randomized controlled trials and observational studies. In obese patients, eligible for bariatric surgery, the changes in pre- and postoperative pain scores, assessed by Numeric Rating Pain Scale (NPS) or Visual Analogue Scale (VAS), were considered as primary outcomes. Effect size (ES) and their 95% confidence intervals (CI) were evaluated. Results: Eight observational studies met the eligibility criteria. All studies showed a reduction of LBP following bariatric surgery, with a mean change of -2.9 points in NPS and of -3.8 cm in VAS. Among the patients undergoing bariatric surgery, based on a fixed effect estimated by pain assessment, the pain score decreased significantly in both groups; in NPS (ES -3.49, 95%CI [-3.86, -3.12]) and in VAS (ES -3.975, 95%CI [-4.45, -3.50]). Conclusions: From this meta-analysis, the data of back pain improvement following bariatric surgery seems encouraging. Substantial weight loss following bariatric surgery might be associated with a reduction in back pain intensity.

1529: Obesity, Bariatric Surgery, and Stone Disease

2006 ◽  
Vol 175 (4S) ◽  
pp. 493-494
Author(s):  
Jared M. Whitson ◽  
G. Bennett Stackhouse ◽  
Marshall L. Stoller
Keyword(s):  
Bariatric Surgery ◽  
Stone Disease
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