scholarly journals Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases

2018 ◽  
pp. 314-319 ◽  
Author(s):  
John Pyne ◽  
Esther Mint ◽  
Elizabeth Barr ◽  
Simon Clark ◽  
Ruihang Hou
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Case Series ◽  
Depth Of Invasion ◽  
Consecutive Case ◽  
Invasion Depth ◽  
Anatomic Site ◽  
Depth Variation

Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies. Objective: To investigate BCC invasion depth variation by subtype and anatomic site. Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic. Results: Descending mean depths for a total of 4,565 BCC cases by subtype were as follows: nodulocystic, 1.9 mm (n = 84, 95% CI: 1.70–2.03, P = 0.66); nodular, 1.6 mm (n = 947, 95% CI: 1.53–1.63, P < 0.0001); aggressive, 1.5 mm (n = 925, 95% CI: 1.44–1.59, P < 0.0001); superficial combined with nodular, 0.9 mm (n = 1,081, 95% CI: 0.83-0.90, P < 0.0001); and superficial, 0.3 mm (n = 1,528, 95% CI: 0.32-0.36, P < 0.0001). Deeper invasion was associated with increased chronic sunlight exposed sites. The deepest aggressive BCCs occurred on the neck with a mean depth of 1.8 mm (n = 46, 95% CI: 1.47–2.21). Conclusion: We found significant differences in the depth of invasion for BCCs by sex, subtype, and anatomic site. For BCC with characteristics matching this study, overall adequate microscopic excision depths are proposed: superficial, 1.0 mm; superficial combined with nodular, 2.0 mm; nodular, 3.0 mm; and aggressive, 3.0 mm.

scholarly journals Tumors associated with radiotherapy: a case series

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Mauricio Garcia ◽  
Dary L. Hernandez ◽  
Sara Mendoza ◽  
Nelson Buelvas ◽  
Angelina Alvarez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Basal Cell Carcinoma ◽  
Cancer Treatment ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Locally Advanced ◽  
Case Series ◽  
Breast Cancer Treatment ◽  
Induced Tumors ◽  
Incidence And Mortality

Abstract Background Breast cancer is the cancer with the highest incidence and mortality worldwide. Its treatment is multidisciplinary with surgery, systemic therapy, and radiotherapy. In Colombia, according to Globocan 2018, there is an age-standardized incidence rate of 44 per 100,000 women. Radiotherapy improves local and regional control in patients with breast cancer, and it could even improve relapse-free survival and overall survival in patients with nodal disease. The toxicity of this treatment in most cases is mild and transient, but in a low percentage of patients, radiotherapy-induced tumors may develop. Case presentation Seven Colombian patients treated for breast cancer at our institution developed radiotherapy-induced tumors between 2008 and 2018. The median age was 54.4 (range 35–72) years. Six patients had locally advanced tumors at the time breast cancer was diagnosed, and all of them received neoadjuvant or adjuvant chemotherapy and radiotherapy. The radiotherapy-induced tumors were five sarcomas, one of which was a well-differentiated angiosarcomatous vascular lesion with negative c-Myc (benign lesion), and the remaining patient had basal cell carcinoma associated with radiotherapy. Conclusions Sarcomas are the most common radiotherapy-induced tumors after breast cancer treatment. These are rare, aggressive tumors and represent between 0.5% and 5.5% of all sarcomas. Basal cell carcinoma has also been associated with breast cancer treatment. The management is individualized and multimodal, including surgical resection and chemotherapy. Different studies have shown that radiation therapy is a risk factor for the development of soft tissue tumors.

scholarly journals Possible recurrence of keratocyst in nevoid basal cell carcinoma syndrome: A review of literature

2013 ◽  
Vol 07 (S 01) ◽  
pp. S126-S134 ◽  
Author(s):  
Bassel Tarakji ◽  
Kusai Baroudi ◽  
Salah Hanouneh ◽  
Saleh Naser Azzeghaiby ◽  
Mohammad Zakaria Nassani
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Literature Search ◽  
Case Series ◽  
General Treatment ◽  
Review Of Literature ◽  
National Library ◽  
Growth Capacity ◽  
Significant Growth

ABSTRACTThis review will highlight some current areas of difficulty or controversy in diagnosis and treatment of nevoid basal cell carcinoma syndrome (NBCCS). The odontogenic keratocyst (OKC) has significant growth capacity and recurrence potential and is occasionally indicative of the NBCCS. The objective of this study is to clarify the causes of the recurrence of OKC in NBCCS. A literature search was conducted using Medline, accessed via the National Library of Medicine PubMed interface, searching for articles relating to the cause of recurrence of keratocyst in NBCCS written in English. This study has described the previous and the current outcomes of the treatment of OKC (recurrent cause). A protocol was then agreed to search for the possible causes of keratocyst recurrence in NBCCS. The general treatment of other manifestation of NBCCS has excluded from this study. Studies describing cohort, case series and miscellaneous clinical reports were retrieved and evaluated from 2010 to 2012.

scholarly journals Keratinocytic Cancers - Ambulatory Surgical Approach: Case Series

2020 ◽  
Vol 7 (4) ◽  
pp. 1-10
Author(s):  
Teodor Angelov ◽  
Ana Bitolska ◽  
Georgi Tchernev
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Case Series ◽  
Complete Removal ◽  
Risk Groups ◽  
Surgical Safety ◽  
Radiation Genetic

The Keratinocytic cancer is the most common form of skin cancer and the most common cancer in humans. Predisposing risk factors include ultraviolet radiation, genetic predisposition, chronic immune suppression, smoking, which also determines the risk groups - middle and old age, light skin phenotype, outdoor work and frequent sunburns. The origin of the epidermal cell type determines the clinical division of keratinocytic cancer into basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Clinically, keratinocytic cancer is presented as a solitary, sometimes destructive, growing-sized lesion. The most lesions are characterized by a low degree of malignancy. Neglecting them by both the patient and medical professionals leads to their growth and metastasis, as SCC has a higher potential for metastasis. The main place in the treatment of keratinocytic cancer is the surgical method, and the most common in clinical practice is the so called elliptical excision. The gold standard in hardto-reach places is the Mohs micrographic operation. In this publication we present eleven clinical cases of patients with keratinocytic cancers in different topographic regions of the human body. Patients were treated surgically by elliptical excision and complete removal of tumor formations in accordance with the recommended fields of surgical safety. The defects were closed with single skin sutures and the sutures were removed on the 14th postoperative day. No complications were observed in the postoperative period. Keywords: Keratinocytic Cancer; Basal Cell Carcinoma; Squamous Cell Carcinoma; Elliptical Excision; Dermatosurgery

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