scholarly journals Dermoscopy as a Tool in Differentiating Cutaneous Squamous Cell Carcinoma From Its Variants

2021 ◽  
pp. e2021050
Author(s):  
Dimitrios Sgouros ◽  
Melpomeni Theofili ◽  
Vasileia Damaskou ◽  
Sofia Theotokoglou ◽  
Konstantinos Theodoropoulos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Diagnostic Accuracy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
High Specificity ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Discriminative Ability ◽  
Bowen Disease ◽  
Low Sensitivity

Background: Dermoscopic features of cutaneous squamous cell carcinoma (cSCC) have been widely studied, but their accuracy should be further investigated. Objectives: This study assessed the diagnostic accuracy of a set of predetermined dermoscopic structures for 3 variants of cSCC, namely Bowen disease, keratoacanthoma and invasive cSCC. Methods: Dermoscopic images of 56 histopathologically confirmed cSCC lesions (9 Bowen disease lesions, 7 keratoacanthomas, and 40 invasive cSCCs) were examined, and the diagnostic accuracy of dermoscopic structures was assessed. Discriminative ability of statistically significant positive predictors was determined using receiver operating characteristic (ROC) curves, and defined as an area under the ROC curve >0.700. Results: Dermoscopic structures with statistical significance and discriminative ability were: for Bowen disease, clustered glomerular vessels and erosions; for keratoacanthoma, a central keratin plug; and for invasive cSCC, a mixed color of the background. Clustered and glomerular vessels had, for Bowen disease, perfect diagnostic accuracy, with: sensitivity of 88.9% for both features; specificity of 97.9% and 93.6%, respectively; positive predictive value (PPV) of 88.9% and 72.7%, respectively; and negative predictive value (NPV) of 97.8% for both. Erosions had, for BD, high specificity (87.2%) and NPV (91.1%), but low sensitivity (55.6%) and PPV (45.5%). A central keratin plug had, for keratoacanthoma, high specificity (87.8%) and NPV (93.5%), but low sensitivity (57.1%) and PPV (40%). A mixed background color had, for invasive cSCC, high specificity (81.3%) and PPV (89.7%), but low sensitivity (65%) and NPV (48.2%). Conclusion: Dermoscopy accurately differentiates BD, through clustered glomerular vessels, from keratoacanthoma and invasive cSCC. Dermoscopic structures of keratoacanthoma and invasive cSCC overlap, and only histopathologic analysis differentiates them precisely.

Role of contrast enhanced computed tomography in assessing cervical lymph node metastases in oral cavity squamous cell carcinoma

2021 ◽  
pp. 1-10
Author(s):  
Talha Ahmed Qureshi ◽  
Muhammad Wasif ◽  
Muhammad Sohail Awan ◽  
Adnan yar Muhammad ◽  
Ainulakbar Mughal ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Diagnostic Accuracy ◽  
Ct Scan ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
P Value ◽  
Contrast Enhanced ◽  
Kappa Value

Abstract Objectives: To evaluate the diagnostic accuracy of contrast enhanced CT scan to detect cervical nodal metastasis in oral cavity squamous cell carcinoma keeping final histopathology as gold standard. Methods: Cross sectional study conducted from 1st January 2015 - 31st October 2016. All patients undergoing surgery who had their CT scans done at our centre were included in the study. Diagnostic accuracy of CT scans was calculated using final histopathology as gold standard. All CT scan were reviewed by consultant radiologist. Results: Total 100 patients were reviewed, 70% were female, 55% had buccal and 32% had tongue cancer. 11 cases of T1, 20 cases of T2 , 4 cases of T3 and 21 cases of T4 stages were staged similarly by CT scan and histopathology, the kappa value of38.8%, p value <0.01. 6 cases of N1, 1 case of N2a , 9 cases of N2b, 3 cases of N2c, 1 case of N3 and 29 cases of N0 stages were staged similarly by CT scan and histopathology, with kappa value of 28.1%, p value of  <0.01. Sensitivity, specificity, positive predictive value, negative predictive value and overall diagnostic accuracy were 83%,61%,70.9%,76.3% and 73% respectively. Conclusion: CT scan is useful for preoperative staging of oral cavity squamous cell carcinoma with an overall diagnostic accuracy of 73%, currently there are no superior diagnostic modalities. However, Due to low specificity and negative predictive value elective neck dissection should still be done in a negative CT scan for cervical lymph node metastases. Keywords: Oral Cavity,

Predictive Value of Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma Based on the AJCC-8 and Brigham and Women's Hospital Staging Criteria

2020 ◽  
Vol 46 (7) ◽  
pp. 857-862
Author(s):  
Antonio Tejera-Vaquerizo ◽  
Javier Cañueto ◽  
Beatriz Llombart ◽  
Antonio Martorell-Calatayud ◽  
Onofre Sanmartín
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Lymph Node Biopsy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Node Biopsy

scholarly journals 101 Potential role of the OVOL1–OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma from Bowen disease

2017 ◽  
Vol 137 (5) ◽  
pp. S17
Author(s):  
T. Ito ◽  
G. Tsuji ◽  
F. Ohno ◽  
T. Nakahara ◽  
H. Uchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Potential Role ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Bowen Disease

scholarly journals Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 6 ◽  
Author(s):  
Theo Crawford ◽  
Nicholas Fletcher ◽  
Margaret Veitch ◽  
Jazmina L. Gonzalez Cruz ◽  
Nicola Pett ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Mouse Model ◽  
Bacillus Anthracis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protective Antigen ◽  
High Specificity ◽  
Cutaneous Squamous Cell Carcinoma

Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck

2017 ◽  
Vol 117 (4) ◽  
pp. 765-772 ◽  
Author(s):  
Jessica Liu ◽  
Ardalan Ebrahimi ◽  
Tsu-Hui Hubert Low ◽  
Kan Gao ◽  
Carsten E. Palme ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Staging System ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Joint Commission ◽  
Nodal Staging ◽  
8Th Edition

Role of Clinical Palpation in Evaluation of Cervical Lymph Node in Oral Squamous Cell Carcinoma

2013 ◽  
Vol 1 (2) ◽  
pp. 02-06
Author(s):  
SM Anwar Sadat ◽  
Sufia Nasrin Rita ◽  
Shoma Banik ◽  
Md Nazmul Hasan Khandker ◽  
Md Mahfuz Hossain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cervical Lymph Node ◽  
Betel Quid ◽  
Cervical Lymph Nodes

A cross sectional study of 29 cases of oral squamous cell carcinoma with or without  cervical lymph node metastasis was done among Bangladeshi patients from January 2006 to December 2007. Majority of the study subjects (34.5%) belonged to the age group of 40-49 years. 58.6% of the study subjects were male, while remaining 41.4% of them were female. 51.7% of the lesions were located in the alveolar ridge where the other common sites were buccal mucosa (27.6%) and retro molar area (13.8%). Half of the study subjects (51.7%) were habituated to betel quid chewing followed by 37.9% and 10.3% were habituated to smoking and betel quid-smoking respectively. Grade I lesions was most prevalent (75.9%) in the study subjects.  Majority of cases presented with Stage IV lesions (55.2%). The sensitivity, specificity, positive predictive value, negative predictive value & accuracy of clinical palpation method for determining metastatic cervical lymph nodes were 93.33%, 64.29%, 73.68%, 90% and 79.3% respectively. Careful and repeated clinical palpation plays important role in evaluation of cervical lymph nodes though several modern techniques may help additionally in the management of oral cancer.DOI: http://dx.doi.org/10.3329/updcj.v1i2.13978 Update Dent. Coll. j. 2011: 1(2): 02-06

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