Hantavirus Pulmonary Syndrome Is Distinguishable From Acute Interstitial Pneumonia

2000 ◽  
Vol 124 (10) ◽  
pp. 1463-1466
Author(s):  
Thomas V. Colby ◽  
Sherif R. Zaki ◽  
Richard M. Feddersen ◽  
Kurt B. Nolte
Keyword(s):  
Viral Infection ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Hantavirus Pulmonary Syndrome ◽  
Pulmonary Vasculature ◽  
Diffuse Lung Disease ◽  
Acute Interstitial Pneumonia ◽  
Clinical Presentations ◽  
Acute Changes ◽  
Diffuse Lung

Abstract Context.—Hantavirus pulmonary syndrome (HPS) and acute interstitial pneumonia (AIP) can share similar clinical presentations. AIP is an acute, diffuse lung disease that has some clinical features suggesting a viral infection, although causative agent(s) have not been identified. Objective.—To clinically, histologically, and immunohistochemically compare cases of HPS to cases of AIP and to determine if any cases of AIP were actually examples of HPS. Design.—Seven cases of HPS and 9 cases of AIP were compared clinically and histologically by semiquantitative grading of features in lung tissue. The cases were also evaluated immunohistochemically for the presence of hantaviral antigens. Results.—Hantavirus pulmonary syndrome had a shorter clinical duration and more acute changes histopathologically; AIP was of longer clinical duration and was usually accompanied by histologic evidence of organization. Hantavirus pulmonary syndrome was distinguished by the presence of immature leukocytes in the pulmonary vasculature. No hantaviral antigens were identified immunohistochemically in the 9 case of AIP. Hantaviral antigens were identified in all 7 cases of HPS. Conclusion.—Cases of AIP and fatal cases of HPS can generally be distinguished on clinical and histologic grounds, and this distinction can be further confirmed immunohistochemically.

scholarly journals Anticoagulant Use as an Independent Risk Factor and Higher In-Hospital Mortality in Patients Showing Alveolar Hemorrhage in Diffuse Lung Disease

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1094
Author(s):  
Motoi Ugajin ◽  
Hisanori Kani ◽  
Hideo Hattori
Keyword(s):  
Risk Factor ◽  
Hospital Mortality ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Lupus Erythematosus ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Alveolar Hemorrhage ◽  
Diffuse Lung Disease ◽  
Diffuse Lung

Background and objectives: Bronchoalveolar lavage (BAL) is commonly performed to evaluate diffuse lung disease and occasionally to identify alveolar hemorrhage. However, the clinical impact of alveolar hemorrhage and its risk factors in patients with diffuse lung disease have not been clarified. Materials and Methods: We retrospectively analyzed the medical records of all patients who underwent BAL to evaluate diffuse lung disease from January 2017 to December 2020. Alveolar hemorrhage was defined as progressive hemorrhagic BAL fluid or the presence of ≥20% hemosiderin-laden macrophages in the BAL fluid. Logistic regression analysis was performed to assess the association between alveolar hemorrhage and other factors. Results: Sixty subjects were enrolled in this study. Alveolar hemorrhage was observed in 19 subjects (31.7%) with idiopathic interstitial pneumonia, acute respiratory distress syndrome, interstitial pneumonia with autoimmune features, drug-induced lung injury, eosinophilic pneumonia, adenocarcinoma, and systemic lupus erythematosus. The use of anticoagulants was a significant risk factor for alveolar hemorrhage (odds ratio 7.57, p = 0.049). Patients with alveolar hemorrhage required intubated mechanical ventilation more frequently (63.2% vs. 24.4%, p = 0.005) and had higher in-hospital mortality rates (26.3% vs. 4.9%, p = 0.028) than those without alveolar hemorrhage. Conclusions: Alveolar hemorrhage was observed in various etiologies. The use of anticoagulants was a significant risk factor for alveolar hemorrhage. Patients with alveolar hemorrhage showed more severe respiratory failure and had higher in-hospital mortality than those without alveolar hemorrhage.

scholarly journals Clinical Analysis of Transbronchial Cryobiopsy in Diagnosis of Diffuse Lung Disease

2021 ◽  
Author(s):  
Yefei Zhu ◽  
Xuling Zhao ◽  
Haihong Zheng ◽  
Jiaxi Feng ◽  
Zhenjie Wu ◽  
...  
Keyword(s):  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Granulomatous Inflammation ◽  
Cost Effective ◽  
Diagnostic Value ◽  
Clinical Analysis ◽  
Allergic Alveolitis ◽  
Diffuse Lung Disease ◽  
Alveolar Proteinosis ◽  
Diffuse Lung

Abstract Background: Rapid advances in TBCB in recent years have allowed its gradual acceptance as a diagnostic method for DLD, and an alternative to surgical lung biopsy . However, the various guidelines have yet to provide clear recommendations for TBCB. This study investigated the diagnostic value of transbronchial cryobiopsy (TBCB) for identifying diffuse lung disease (DLD) .Methods: The clinical data was reviewed of 34 patients who showed initial signs of diffuse lung lesions, interstitial pneumonia, bronchial asthma, lung cancer/infection, or pulmonary alveolar proteinosis; and underwent TBCB from December 2018 to March 2021. The safety and effectiveness of TBCB in identifying the etiology of DLD was analyzed.Results: Clear pathomorphological diagnoses were obtained for 27 (79.4%) patients, based on clinical characteristics and pathology: pulmonary fibrosis, adenocarcinoma, alveolar proteinosis, extrinsic allergic alveolitis, tuberculous granulomatous inflammation, and interstitial pneumonia. Four (11.8%) patients required multi-disciplinary discussion for diagnostic confirmation (of diffuse lesions, interstitial pneumonia, and lung infection). The etiology of 3 cases remained unknown. The rate of DLD diagnosis via TBCB was 91.2% (31/34). Associated with the TBCB procedure, 9 (26.5%) patients developed pneumothorax (6 mild, 3 moderate), and 29 (85.3%) post-biopsy bleeding (all grade 1, requiring suction and compression, but no other intervention or surgery). The average hospitalization cost and length of stay were 7988 RMB (1233 USD) and 5.48 days, respectively.Conclusion: TBCB is safe, cost-effective, requires a short hospitalization, and the diagnostic confirmation rate for DLD is high.

scholarly journals Learning curve for transbronchial lung cryobiopsy in diffuse lung disease

Pulmonology ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 23-31 ◽  
Author(s):  
L.M. Almeida ◽  
B. Lima ◽  
P.C. Mota ◽  
N. Melo ◽  
A. Magalhães ◽  
...  
Keyword(s):  
Learning Curve ◽  
Lung Disease ◽  
Diffuse Lung Disease ◽  
Transbronchial Lung Cryobiopsy ◽  
Diffuse Lung

scholarly journals Sleep in children and young adults with interstitial and diffuse lung disease

2021 ◽  
Vol 80 ◽  
pp. 23-29
Author(s):  
Diane Abdel-Latif Thomasson ◽  
Rola Abou Taam ◽  
Laureline Berteloot ◽  
Sonia Khirani ◽  
Lucie Griffon ◽  
...  
Keyword(s):  
Young Adults ◽  
Lung Disease ◽  
Diffuse Lung Disease ◽  
Children And Young Adults ◽  
Diffuse Lung

Open lung biopsy in patients on mechanical ventilation with suspected diffuse lung disease

2009 ◽  
Vol 15 (4) ◽  
pp. 597-611
Author(s):  
Natália Melo ◽  
Sandra Figueiredo ◽  
António Morais ◽  
Conceição Souto Moura ◽  
Paulo Pinho ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Lung Disease ◽  
Lung Biopsy ◽  
Open Lung Biopsy ◽  
Diffuse Lung Disease ◽  
Open Lung ◽  
Diffuse Lung

Incidence and prevalence of children’s diffuse lung disease in Spain

2021 ◽  
Author(s):  
Alba Torrent-Vernetta ◽  
Mirella Gaboli ◽  
Silvia Castillo-Corullón ◽  
Pedro Mondéjar-López ◽  
Verónica Sanz Santiago ◽  
...  
Keyword(s):  
Lung Disease ◽  
Diffuse Lung Disease ◽  
Diffuse Lung

Imaging of Lung Disease, Part i: Focal and Diffuse Parenchymal Lung Diseases

2018 ◽  
Author(s):  
Gerald W. Staton Jr ◽  
Eugene A Berkowitz ◽  
Adam Bernheim
Keyword(s):  
Differential Diagnosis ◽  
Lung Disease ◽  
Clinical Information ◽  
Diffuse Lung Disease ◽  
Lipoid Pneumonia ◽  
Diffuse Parenchymal Lung Diseases ◽  
Parenchymal Disease ◽  
Parenchymal Lung Disease ◽  
Diffuse Lung ◽  
Parenchymal Lung

Parenchymal lung disease often presents on imaging with particular patterns that allow for recognition of certain clinical entities that may form the basis for an imaging differential diagnosis. Focal pulmonary opacities and multi-focal pulmonary opacities may be due to an infectious or neoplastic etiology, amongst other possibilities. Segmental/lobar opacities are also associated with a set of differential diagnoses. Diffuse parenchymal disease, while also associated with some infections and neoplasms, can additionally be seen in the setting of pneumoconioses and several idiopathic interstitial pneumonias. Combining clinical information including laboratory results with the imaging findings on chest radiography and computed tomography (CT) allows the physician to formulate an appropriate differential diagnosis or reach one specific diagnosis. This review contains 16 figures, 4 tables and 32 references Keywords: Pulmonary Opacity, Pulmonary Infection, Eosinophilic Pneumonia, Lipoid Pneumonia, Pulmonary Tuberculosis, Organizing Pneumonia, Lung Cancer, Diffuse Lung Disease, Pneumoconiosis, Idiopathic Interstitial Pneumonia

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