Follicular Lymphoma With a Burkitt Translocation—Predictor of an Aggressive Clinical Course: A Case Report and Review of the Literature
2004 ◽
Vol 128
(2)
◽
pp. 210-213
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Keyword(s):
Abstract Follicular lymphoma is an indolent lymphoma characterized by the (14;18) translocation, which leads to aberrant expression of Bcl-2. Translocations involving 8q24 are most commonly associated with Burkitt lymphoma and result in c-Myc overexpression. We report a case of follicular lymphoma of predominant small cleaved-cell type (grade 1) associated with both a t(14;18)(q32;q21) and a t(8;22)(q24;q11). The 8q24 translocation predicted an aggressive clinical course, as the lymphoma transformed into acute lymphoblastic leukemia within a year of initial diagnosis. Routine cytogenetic analysis is recommended at initial diagnosis of follicular lymphoma to better identify abnormalities that may predict prognosis and influence therapy.
2018 ◽
Vol 27
(3)
◽
pp. 328-335
2018 ◽
Vol 27
(3)
◽
pp. 322-327
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2018 ◽
Vol 149
(suppl_1)
◽
pp. S21-S22
2003 ◽
Vol 127
(5)
◽
pp. 610-613
1998 ◽
Vol 77
(1)
◽
pp. 51-55
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2012 ◽
Vol 16
(6)
◽
pp. 438-441
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1987 ◽
Vol 11
(1)
◽
pp. 83-87
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