A Case of Fatal Disseminated Bartonella henselae Infection (Cat-Scratch Disease) With Encephalitis

2007 ◽  
Vol 131 (10) ◽  
pp. 1591-1594
Author(s):  
Brandy Fouch ◽  
Susan Coventry
Keyword(s):  
Bartonella Henselae ◽  
Neurologic Manifestations ◽  
Cat Scratch Disease ◽  
Systemic Dissemination ◽  
Lymphocytic Infiltrates ◽  
The Brain ◽  
Limited Process

Abstract Cat-scratch disease resulting from Bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. Even the rare cases associated with neurologic manifestations are not generally fatal. We report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. Autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. To our knowledge, this finding has not been previously reported in B henselae infection, possibly because of the paucity of material available for complete neuropathologic evaluation. This case illustrates the extreme severity of the spectrum with which cat-scratch disease can present and provides evidence of brain histopathology that may be representative of the disease.

scholarly journals Cat scratch disease as zoonosis: Pathogenesis, clinical symptoms, diagnosis.

2018 ◽  
Vol 74 (1) ◽  
pp. 5997-2018
Author(s):  
ŁUKASZ MAZUREK ◽  
STANISŁAW WINIARCZYK ◽  
ŁUKASZ ADASZEK
Keyword(s):  
Clinical Symptoms ◽  
Bartonella Henselae ◽  
Unknown Origin ◽  
Skin Lesions ◽  
Cat Scratch Disease ◽  
Serological Tests ◽  
Antibody Titres ◽  
Polymerase Chain ◽  
Brain And Spinal Cord ◽  
The Brain

The cat scratch disease in humans is caused by the bacteria Bartonella henselae. The disease can take many different forms: from asymptomatic cases, cases of skin lesions, fever of unknown origin, enlargement of lymph nodes, ophthalmologic disorders, to severe cases involving inflammation of the brain and spinal cord or endocarditis. The reservoir of B. henselae for humans are domestic animals, especially cats. The diagnosis of the disease is based on data from the anamnesis, the patient’s confirmed exposure to cats, and the results of serological tests showing an increase in antibody titres for B. henselae. The disease can also be confirmed by positive results of the polymerase chain reaction (PCR). No vaccines against bartonellosis are available. The most important in preventing the disease is to maintain appropriate hygiene in contact with cats and dogs, and to eradicate the vectors of Bartonella, such as fleas..

scholarly journals Cervical Cat Scratch Disease Lymphadenitis in a Patient with Immunoglobulin M Antibodies to Toxoplasma gondii

2002 ◽  
Vol 9 (2) ◽  
pp. 496-498
Author(s):  
Mardjan Arvand ◽  
Ilkay Kazak ◽  
Sergije Jovanovic ◽  
Hans-Dieter Foss ◽  
Oliver Liesenfeld
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Symptoms ◽  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Immunoglobulin M ◽  
Cat Scratch Disease ◽  
Specific Immunoglobulin ◽  
Acute Toxoplasmosis

ABSTRACT We report on a young patient with chronic cervical lymphadenopathy and serological and histological evidence for infection with Bartonella henselae and Toxoplasma gondii. Serological follow-up studies, including testing for avidity of Toxoplasma-specific immunoglobulin G antibodies, assisted in the determination of the cause of the acute lymphadenitis. Our results suggest that the clinical symptoms were most likely due to cat scratch disease rather than to acute toxoplasmosis.

Positional Hand Pallor and Isolated Epitrochlear Lymphadenitis Secondary to Bartonella henselae Infection.

2021 ◽  
Vol 20 (4) ◽  
pp. 914-917
Author(s):  
Siti Nuradliah Jamil ◽  
Ilham Ameera Ismail ◽  
Siti Fatimah Badlishah Sham ◽  
Norliana Dalila Mohamad Ali
Keyword(s):  
Lymph Node ◽  
Communicable Disease ◽  
Bartonella Henselae ◽  
Medical Science ◽  
Neck Region ◽  
Rare Condition ◽  
Cat Scratch Disease ◽  
Serological Evidence ◽  
External Compression ◽  
Head And Neck Region

Cat scratch disease is a communicable disease caused by the Bartonella henselae bacteria. Regional lymphadenopathy is the hallmark of cat scratch disease and about 75% of lymphadenopathy cases are localized in the head and neck region. An epitrochlear lymphadenopathy is a rare condition at any age and often misdiagnosed as it is not normally palpable. External compression of an enlarged epitrochlear lymph node compromising vascularity was not mentioned in any literature before. We present a case of a 13-year-old girl with right positional ipsilateral hand pallor and epitrochlear lymphadenitis with serological evidence of Bartonella henselae infection. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.914-917

The Bartonella henselae sucB gene encodes a dihydrolipoamide succinyltransferase protein reactive with sera from patients with cat-scratch disease

2004 ◽  
Vol 53 (12) ◽  
pp. 1221-1227 ◽  
Author(s):  
Christine M Litwin ◽  
Joel M Johnson ◽  
Thomas B Martins
Keyword(s):  
Coxiella Burnetii ◽  
Brucella Melitensis ◽  
Bartonella Henselae ◽  
Immunoblot Analysis ◽  
Cross Reactivity ◽  
Cosmid Library ◽  
Cat Scratch Disease ◽  
Igg Antibodies ◽  
Bacillary Angiomatosis ◽  
Dihydrolipoamide Succinyltransferase

Bartonella henselae is a recently recognized pathogenic bacterium associated with cat-scratch disease, bacillary angiomatosis and bacillary peliosis. A recombinant clone expressing an immunoreactive antigen of B. henselae was isolated by screening a genomic DNA cosmid library by Western blotting with sera pooled from patients positive for B. henselae IgG antibodies by indirect immunofluorescence (IFA). The deduced amino acid sequence of the 43.7 kDa encoded protein was found to be 76.3 % identical to the dihydrolipoamide succinyltransferase enzyme (SucB) of Brucella melitensis. SucB has been shown to be an immunogenic protein during infections by Brucella melitensis, Coxiella burnetii and Bartonella vinsonii. The agreement between reactivity with a recombinant SucB fusion protein on immunoblot analysis and the results obtained by IFA was 55 % for IFA-positive sera and 88 % for IFA-negative sera. Cross-reactivity was observed with sera from patients with antibodies against Brucella melitensis, Mycoplasma pneumoniae, Francisella tularensis, Coxiella burnetii and Rickettsia typhi.

scholarly journals Cat-Scratch disease in Crete: an update

2011 ◽  
Vol 3 (2) ◽  
pp. 15 ◽  
Author(s):  
Georgios Minadakis ◽  
Emmanouil Angelakis ◽  
Dimosthenis Chochlakis ◽  
Yannis Tselentis ◽  
Anna Psaroulaki
Keyword(s):  
Bartonella Henselae ◽  
Immunofluorescence Assay ◽  
Positive Lymph Node ◽  
Cat Scratch Disease ◽  
Outdoor Activity ◽  
Pcr Assay ◽  
Serum Samples ◽  
Molecular Assays ◽  
Number Of Patients ◽  
Whole Blood Sample

There are few epidemiological and clinical studies about the presence of cat scratch disease (CSD) on the island of Crete. The objective of this study was to analyze a large number of patients with suspected CSD to define the frequency of <em>Bartonella</em> infections in Crete. From January 2005 to October 2008, we studied patients with suspected CSD from hospitals in Crete. Sera of the referred patients were tested by immunofluorescence assay (IFA). For some patients, we also received lymph nodes and blood samples that we tested for the presence of <em>Bartonella henselae</em> by molecular assays. Overall, we tested 507 serum samples and we found 56 (11%) cases of CSD. PCR assay was positive for 2 patients; one had a <em>B. henselae</em> positive lymph node and the other a positive whole blood sample. Significantly more CSD cases (62.5%, 35 of 56) were reported in children than in infants and adults (P&lt;0.05). Moreover, we identified that most cases of CSD occurred between May and September (P=0.002) and December and January. CSD is prevalent in Crete and is mostly associated with an increase in outdoor activity.

Beyond Cat Scratch Disease: Widening Spectrum of Bartonella henselae Infection

PEDIATRICS ◽  
2008 ◽  
Vol 121 (5) ◽  
pp. e1413-e1425 ◽  
Author(s):  
T. A. Florin ◽  
T. E. Zaoutis ◽  
L. B. Zaoutis
Keyword(s):  
Bartonella Henselae ◽  
Cat Scratch Disease

Bartonella henselae is usually not viable in lymph nodes of patients with cat scratch disease

2017 ◽  
Vol 36 (11) ◽  
pp. 2207-2213 ◽  
Author(s):  
E. Prudent ◽  
H. Lepidi ◽  
G. Audoly ◽  
B. La Scola ◽  
P.-E. Fournier ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Bartonella Henselae ◽  
Cat Scratch Disease
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