Hazardous effects of acrylamide on immature male and female rats

Author(s):  
Sayed M. Rawi
1972 ◽  
Vol 68 (3_Suppl) ◽  
pp. S59
Author(s):  
H. Kuhl ◽  
W. Bickel ◽  
J. Enenkel ◽  
G. Hauptmann ◽  
P. Chandra ◽  
...  

1975 ◽  
Vol 65 (1) ◽  
pp. 91-98 ◽  
Author(s):  
PETER ENEROTH ◽  
JAN-ÅKE GUSTAFSSON ◽  
PAUL SKETT ◽  
ÅKE STENBERG

SUMMARY The concentrations of LH and FSH were measured by radioimmunoassay in sera from immature male and female rats of various ages. Fairly high levels of FSH were found in both sexes at birth but LH was not detected. FSH peaks appeared in the male at 13 and 19 days of age and in the female at 13 and 17–19 days of age. LH was undetectable in the male before 12 days of age, rose to a peak (440 ± 60 (s.d.) ng/ml) at 13 days of age and fell below the detection level again between 15 and 25 days of age. A further increase then occurred which almost reached adult levels. LH was first detectable in the female rat at 11 days of age with a peak value of 130 ± 35 ng/ml at 12 days. The hormone was undetectable on days 14 and 15, rose to a second peak on day 18 (148 ± 56 ng/ml), and was again absent between 19 and 25 days of age. The concentration rose, as in the male, between days 25 and 28 to a level similar to that of the adult. The results show sexual differences in prepubertal gonadotrophin surges. The LH peak at 12–13 days in both sexes appears to be light-dependent. The FSH peak at this time was affected by light but was not strictly light-dependent.


Endocrinology ◽  
1978 ◽  
Vol 103 (3) ◽  
pp. 724-735 ◽  
Author(s):  
CARL DENEF ◽  
EMMY HAUTEKEETE ◽  
ANNEMIE DE WOLF ◽  
BERNADETTE VANDERSCHUEREN

1969 ◽  
Vol 47 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Janet M. Wardlaw ◽  
Donna J. Hennyey ◽  
Ruth H. Clarke

Ninety-day-old male and female rats of the Wistar strain were force-fed a liquefied diet twice daily for a 2-week experimental period. The amounts fed corresponded to ad libitum intakes of similar groups of animals fed the diet in the dry state. The animals were adjusted to the feeding technique for 1 week prior to the experimental period. At the end of the experimental period the carcasses of the force-fed animals and the ad libitum control groups were analyzed for fat, nitrogen, and moisture content. The frequency of feeding had no significant effect on percentage carcass fat, but lessened frequency of feeding was associated with a decrease in percentage carcass protein (N × 6.25) which was of slight significance. Subsequently, 35-day-old animals were treated similarly. In the younger animals the method of feeding had a significant effect on carcass fat, with an increase in fat content in the force-fed animals which was apparent in the males but was not of significance in the females. The increased fat deposition in the immature male animals was accompanied by a decreased weight gain. A significant decrease in percentage carcass protein was observed in the immature force-fed animals.


1990 ◽  
Vol 143 (6) ◽  
pp. 1267-1271 ◽  
Author(s):  
Alexa L. Chun ◽  
Alan J. Wein ◽  
Richard Harkaway ◽  
Robert M. Levin

1961 ◽  
Vol 38 (1) ◽  
pp. 50-58 ◽  
Author(s):  
N. E. Borglin ◽  
L. Bjersing

ABSTRACT Oestriol (oestra-1,3,5(10)-triene-3,16α,17β-triol) is a weakly oestrogenic substance which, however, in contrast to what was formerly believed, is of physiological significance. Its effect is localized largely to the uterine cervix and vagina. Clinical experience argues both for and against an effect on the pituitary gland. This investigation is concerned with the morphological changes in the pituitary gland and adrenal cortex of gonadectomized male and female rats after the injection of oestriol. It was found that oestriol has the same type of action on these glands as other oestrogens, but under the experimental conditions used, this effect proved much weaker than that produced by oestradiol (oestra-1,3,5(10)-triene-3,17β-diol).


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