scholarly journals Human Factor Research on the Measurement of Subjective Three Dimensional Fatigue

2010 ◽  
Vol 15 (5) ◽  
pp. 607-616 ◽  
Author(s):  
Hyung-Chul O. Li
Keyword(s):  
Human Factor ◽  
Three Dimensional ◽  
Human Factor Research

Characterization of Monoclonal Anti-human Factor VII Antibody (B101/B1) that Recognized Three-dimensional Structures near Arg at Position 79 in the First EGF-like Domain

1998 ◽  
Vol 79 (01) ◽  
pp. 104-109 ◽  
Author(s):  
Osamu Takamiya
Keyword(s):  
Monoclonal Antibodies ◽  
Tissue Factor ◽  
Human Factor ◽  
Solid Phase ◽  
Three Dimensional ◽  
Coagulation Factors ◽  
Factor Vii ◽  
Dimensional Structure ◽  
Epidermal Growth

SummaryMurine monoclonal antibodies (designated hVII-B101/B1, hVIIDC2/D4 and hVII-DC6/3D8) directed against human factor VII (FVII) were prepared and characterized, with more extensive characterization of hVII-B101/B1 that did not bind reduced FVIIa. The immunoglobulin of the three monoclonal antibodies consisted of IgG1. These antibodies did not inhibit procoagulant activities of other vitamin K-dependent coagulation factors except FVII and did not cross-react with proteins in the immunoblotting test. hVII-DC2/D4 recognized the light chain after reduction of FVIIa with 2-mercaptoethanol, and hVIIDC6/3D8 the heavy chain. hVII-B101/B1 bound FVII without Ca2+, and possessed stronger affinity for FVII in the presence of Ca2+. The Kd for hVII-B101/B1 to FVII was 1.75 x 10–10 M in the presence of 5 mM CaCl2. The antibody inhibited the binding of FVII to tissue factor in the presence of Ca2+. hVII-B101/B1 also inhibited the activation of FX by the complex of FVIIa and tissue factor in the presence of Ca2+. Furthermore, immunoblotting revealed that hVII-B101/B1 reacted with non-reduced γ-carboxyglutaminic acid (Gla)-domainless-FVII and/or FVIIa. hVII-B101/B1 showed a similar pattern to that of non-reduced proteolytic fragments of FVII by trypsin with hVII-DC2/D4 on immunoblotting test. hVII-B101/B1 reacted differently with the FVII from the dysfunctional FVII variant, FVII Shinjo, which has a substitution of Gln for Arg at residue 79 in the first epidermal growth factor (1st EGF)-like domain (Takamiya O, et al. Haemosta 25, 89-97,1995) compared with normal FVII, when used as a solid phase-antibody for ELISA by the sandwich method. hVII-B101/B1 did not react with a series of short peptide sequences near position 79 in the first EGF-like domain on the solid-phase support for epitope scanning. These results suggested that the specific epitope of the antibody, hVII-B101/B1, was located in the three-dimensional structure near position 79 in the first EGF-like domain of human FVII.

scholarly journals The three-dimensional structure of the first EGF-like module of human factor IX: Comparison with EGF and TGF-α

1992 ◽  
Vol 1 (1) ◽  
pp. 81-90 ◽  
Author(s):  
M. Baron ◽  
D.G. Norman ◽  
T.S. Harvey ◽  
I.D. Campbell ◽  
P.A. Handford ◽  
...  
Keyword(s):  
Human Factor ◽  
Three Dimensional ◽  
Factor Ix ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Human Factor Ix

scholarly journals Disease-associated Sequence Variations Congregate in a Polyanion Recognition Patch on Human Factor H Revealed in Three-dimensional Structure

2006 ◽  
Vol 281 (24) ◽  
pp. 16512-16520 ◽  
Author(s):  
Andrew P. Herbert ◽  
Dusan Uhrín ◽  
Malcolm Lyon ◽  
Michael K. Pangburn ◽  
Paul N. Barlow
Keyword(s):  
Human Factor ◽  
Three Dimensional ◽  
Factor H ◽  
Dimensional Structure ◽  
Three Dimensional Structure ◽  
Sequence Variations

Immersive technologies will reduce the likelihood of accidents at industrial plants

2020 ◽  
pp. 55-60
Author(s):  
I.V. Simonov
Keyword(s):  
Virtual Reality ◽  
Human Factor ◽  
Negative Impact ◽  
Three Dimensional ◽  
3 Dimensional ◽  
Emergency Situations ◽  
Industrial Enterprises ◽  
Industrial Companies ◽  
Real Objects ◽  
Immersive Technologies

One of the causes of accidents at industrial enterprises is most often the human factor. In pursuit of zero injury, industrial companies strive to improve the quality of employee training. Solutions based on immersive technologies are being introduced into the production process, for example, simulators for training employees to work with equipment based on virtual reality (VR) or three-dimensional graphics (3-dimensional, 3D). Such technologies replace the practice of working on real equipment and allow deeper training of skills in a safe environment. In addition, using virtual reality, you can simulate any emergency situations that are unacceptable to be created on real objects. All this subsequently helps to reduce the negative impact of the human factor on production, and therefore, to reduce the likelihood of injuries, accidents or even fatalities at enterprises.

FRAMEWORK OF AUGMENTED REALITY APPROACH TOWARDS ERGONOMIC ASSESSMENT OF DRIVER VEHICLE PACKAGE DESIGN

2015 ◽  
Vol 77 (27) ◽  
Author(s):  
Chew Sze Soon ◽  
Raja Ariffin Raja Ghazilla ◽  
Yap Hwa Jen ◽  
Pai Yun Suen
Keyword(s):  
Augmented Reality ◽  
Human Factor ◽  
Three Dimensional ◽  
Package Design ◽  
Visual Model ◽  
Head Mounted Display ◽  
Additional Equipment ◽  
Physical Prototype ◽  
Tools And Methods ◽  
Ergonomic Evaluation

Human factor studies such as ergonomic evaluation become increasingly important in the engineering, automotive, designing and support of new advance products. Creating in-car gadgets that can be worked inside appropriate safety bound is an ergonomic issue. Several tools and methods have been developed for ergonomic evaluation. However, there are several factors that influence the difficulty of such evaluations, such as the subjectivity of comfort, high cost of mock-up systems and computerized tools, and the disadvantage of reconfiguring adjustments. The proposed system allows the user or engineer to obtain the three-dimensional visual model with the aid of additional equipment that includes a Augmented Reality head mounted display (HMD) to reduce the components of physical prototype. The user or engineer is able to determine the position of interior components to determine the most comfortable ergonomic reaching zone.  

HRV Monitoring for Human Factor Research in UAS

2013 ◽  
Author(s):  
Brandon Stark ◽  
Tejal Patel ◽  
YangQuan Chen
Keyword(s):  
Human Factors ◽  
Human Factor ◽  
Vital Role ◽  
National Airspace System ◽  
Human Errors ◽  
Feedback Information ◽  
General Acceptance ◽  
Potential Applications ◽  
Human Factor Research ◽  
Significant Factors

Though Unmanned Aerial System (UAS) operators have started to push for general acceptance into the National Airspace System (NAS), there remain significant and necessary areas of research. Despite the ‘Unmanned’ moniker, human factors serve a vital role in safe and robust operation. Numerous reports have placed human errors as significant factors in recent UAS incidents, leading many researchers to investigate a framework for analyzing these human factors that lead to incidents. In this paper, the use of Heart Rate Variability (HRV), as an indicator of operator pressure or cognitive load of a UAS operator, is considered. Furthermore, potential applications of HRV research are presented towards applying this new layer of human feedback information to adjust UAS operations to achieve a safer and more resilient UAS. This paper serves as an initial proposal for this bigger closed-loop thinking in UAS human factor research.

Human Factors Guidelines for the Use of Synthetic Speech Devices

1982 ◽  
Vol 26 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Thomas R. Edman
Keyword(s):  
Human Factors ◽  
Human Factor ◽  
Industrial Applications ◽  
Synthetic Speech ◽  
Speech Communication ◽  
Training And Education ◽  
Human Factor Research ◽  
Perceptual Psychology ◽  
And Linguistics

Synthetic speech devices have attracted considerable attention in the last several years, and are found in consumer, military, or industrial applications. A body of literature on synthetic speech can be assembled from human factor research and from research in perceptual psychology and linguistics. This literature includes research on the intelligibility, comprehension and acceptability of synthetic speech, work on the use of synthetic speech in multi-task situations, and studies of the function and utility of synthetic speech for alarming and annunciation, and for training and education. A review of this literature will be presented. In addition, standard human factors references and guides for speech communication are analyzed for their applicability to modern synthetic speech technologies.

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