scholarly journals Evaluation of Characteristics of the Dental Maturity in Girls with Precocious Puberty

2020 ◽  
Vol 47 (3) ◽  
pp. 312-319
Author(s):  
Chi Hoon Kim ◽  
Chung-Min Kang ◽  
Ik-Hwan Kim ◽  
Je Seon Song ◽  
Seong Oh Kim
Keyword(s):  
Precocious Puberty ◽  
Control Group ◽  
Tooth Formation ◽  
Panoramic Radiographs ◽  
Secondary Sexual Characteristics ◽  
Maturity Score ◽  
Sexual Characteristics ◽  
History Of ◽  
Mandibular Teeth ◽  
Dental Maturity

Precocious puberty (PP) is defined as the early development of secondary sexual characteristics (before the ages of 8 years in girls and 9 years in boys). The aim of this study is to identify characteristics of the dental maturity in girls with PP that discriminate them from normal healthy girls.This study included 99 girls aged 6 - 8 years with PP and 99 girls without past medical history of same chronological age (control group). The study was performed on 198 panoramic radiographs (99 PP girls, 99 control group girls). Demirjian method was used to evaluate the panoramic radiographs and determine dental maturity. Difference in dental maturity score and tooth formation stages between the two groups were analyzed.The PP group showed significant higher maturity score than control group. Among mandibular teeth, mandibular 2nd premolar and 2nd molar were significantly more mature in the PP group than control group. Logistic regression analysis showed that mandibular 2nd molar was only significant predictor for PP girls.

scholarly journals Hetero sexual precocious puberty: Case report and literature review

2016 ◽  
Vol 4 (1) ◽  
pp. 12
Author(s):  
Zujaja Hina Haroon ◽  
Aamir Ijaz ◽  
Muhammad Asad Haroon ◽  
Shahid Ahmed ◽  
Muhammad Amjad Pervez ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Clinical Approach ◽  
Adrenal Hyperplasia ◽  
Rare Presentation ◽  
Secondary Sexual Characteristics ◽  
Sex Development ◽  
Serum Chloride ◽  
Sexual Characteristics ◽  
History Of ◽  
Current Report

Congenital adrenal hyperplasia (CAH) is the most frequent disorder of sex development (DSD). It follows variable clinical course.We present a rare case of CAH that remained clinical enigma. A 6-year-old boy presented with increased pigmentation, deepeningof voice and appearance of male secondary sexual characteristics. There was history of frequent episodes of ill health withcough, fever, diarrhea and off and on vomiting. Laboratory workup revealed Serum Sodium 138 mmol/L (Ref Values: 135-145), Serum Potassium 4.1 mmol/L (Ref Values: 3.5-5.0), Serum Chloride 101 mmol/L (Ref Values: 97-106). Hormonal profilerevealed serum 17-OH Progesterone 85.9 nmol/L (Ref Values: 8.0), DHEA-S 861.9 μg/dl (Ref Values: 125-619), Testosterone 23.2 nmol/L (Ref Values: 0.1-2.4), Cortisol 563 nmol/L (Ref Values: 138-690), ACTH 1,152 pg/ml (Ref Values: 10-85), PlasmaActive Renin Mass Conc 45 μIU/ (Ref Values: 8-35 μIU/L), Plasma Aldosterone 115 pmol/L (Ref Values: 140-2,240). X-raybone age = 12 Y ± 6 m depicting precocious puberty. But USG abdomen and pelvis showed small uterus (28 mm × 13 mm× 22 mm) and karyotype revealed 46 XX genotype. Based on typical findings, a diagnosis of CAH with heterosexual precociouspuberty was established. Patient responded well to tablet Hydrocortisone 20 mg 1/2 BD and Mineralocorticoid (Florinef) Tablets 0.1 mg OD. The aim of current report is to revisit clinical approach to DSD with special emphasis to rare presentation of CAHwith heterosexual precocious puberty.

scholarly journals Dandy-Walker variant with precocious puberty: a rare association

2018 ◽  
Vol 11 (1) ◽  
pp. e226281
Author(s):  
Rajesh Rajput ◽  
Sanat Mishra ◽  
Parul Ahlawat ◽  
Pawan Kumar Yadav
Keyword(s):  
Case Report ◽  
Posterior Fossa ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Secondary Sexual Characteristics ◽  
Rare Association ◽  
Dandy Walker Malformation ◽  
Secondary Hypothyroidism ◽  
Sexual Characteristics ◽  
Walker Malformation

Precocious puberty is characterised by premature appearance of secondary sexual characteristics before the age of 7 years in girls and 9 years in boys. Dandy-Walker malformation comprises a spectrum of intracranial malformations of the posterior fossa. We present a case of a 7-year-old male child who has presented with features of central precocious puberty and on further evaluation has been found to have Dandy-Walker variant and secondary hypothyroidism. The following case report describes this association which is extremely rare and has never been described in literature.

scholarly journals Evaluation of characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty

2018 ◽  
Vol 88 (5) ◽  
pp. 582-589 ◽  
Author(s):  
Hee-Kyung Lee ◽  
Sung-Hwan Choi ◽  
Dong Fan ◽  
Kyung-Mi Jang ◽  
Min-Seon Kim ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Strong Positive Correlation ◽  
Plane Angle ◽  
Gonial Angle ◽  
Mandibular Plane ◽  
Mandibular Teeth ◽  
Dental Maturity ◽  
Craniofacial Complex ◽  
Mandibular Plane Angle

ABSTRACT Objectives: To identify unique characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty (CPP). Materials and Methods: This study included 34 Korean girls with idiopathic CPP (mean age, 8.6 ± .5 years) and 28 normal healthy girls of the same chronological age. An initial evaluation of the growth pattern of the craniofacial complex and dental maturity was conducted by analyzing lateral cephalometric and panoramic radiographs. Results: The mandibular ramus height (44.4 ± 4.1 mm) and total mandibular length (10.8 ± 4.3 mm) (P = .004 and .021, respectively) were greater and the lower anterior facial height was lesser (63.2 ± 2.4 mm) (P = .040) in the CPP group than in the reference group. In addition, the gonial angle (12.9 ± 6.1°; P = .045) and the mandibular plane angle (34.9 ± 4.8°; P = .012) were smaller in girls with CPP than in normal healthy girls. All the mandibular teeth were more mature in girls with CPP (P < .001). A strong positive correlation was observed between the mandibular tooth formation stages and the presence of CPP in girls (r = .756 to .957; P < .001). Conclusions: CPP had an effect on the anteroposterior growth of the mandible in the craniofacial complex and the rotation of the mandibular plane angle. Early maturation of the mandibular teeth was observed in girls with CPP.

Women in science: Breaking out of the circle

1992 ◽  
Vol 46 (1) ◽  
pp. 177-182 ◽  
Keyword(s):  
Nineteenth Century ◽  
Social History ◽  
Charles Darwin ◽  
Women In Science ◽  
Late Nineteenth Century ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
History Of ◽  
The 1960S ◽  
The Mind

Marilyn Bailey Ogilvie, Women in science, antiquity through the nineteenth century . Cambridge, Massachusetts: MIT Press, 1986. Pp. xi 4- 254, £24.75. ISBN 0-262-15031-X Margaret Alic, Hypatia's heritage: a history of women in science from antiquity to the late nineteenth century . London: The Women’s Press, 1986. Pp. ix + 230, £4.95. ISBN 0-7043-3954-4 Londa Schiebinger, The mind has no sex? Women in the origins of modem science . Cambridge, Massachusetts: Harvard University Press, 1989. Pp. xi + 355, £23.50. ISBN 0-674-57623-3 Patricia Phillips, The scientific lady: a social history of woman's scientific interests 1520-1918 . London: Weidenfeld and Nicolson, 1990. Pp. xiii + 279, £25.00. ISBN 0-297-82043-5 Uneasy careers and intimate lives: women in science, 1789-1979 . Edited by Pnina G. Abir-Am & Dorinda Outram. New Brunswick: Rutgers University Press, 1987. Pp. xiii + 365, £11.00. ISBN 0-8135-1255-7 Women of science: righting the record . Edited by G. Kass-Simon & Patricia Fames. Bloomington, Indiana: Indiana University Press, 1990. Pp. xvi + 398, $39.95. ISBN 0-253-33264-8 Not long ago women were largely absent from the histories of science, even from social histories of science. With the 1960s came the questions: where were the women? how to do them justice? were there so few? why so few? Several books have now addressed these difficult questions. Charles Darwin gave an answer to the last question, by including ‘the intellectual powers of the sexes’ with the secondary sexual characteristics discussed in The descent of man, and selection in relation to sex .

Puberty and its disorders

2020 ◽  
pp. 49-82
Author(s):  
Gary Butler ◽  
Jeremy Kirk
Keyword(s):  
Precocious Puberty ◽  
Hypogonadotropic Hypogonadism ◽  
Hormone Secretion ◽  
Central Precocious Puberty ◽  
Pituitary Tumour ◽  
Cancer Treatments ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Fertility Potential ◽  
Secondary Sexual

• Puberty is defined as the acquisition of secondary sexual characteristics, with a view to reproductive capability. • Assessment of puberty can be done by Tanner stages or the puberty phases. • Timing of pubertal onset and sequence of changes is carefully controlled. • Premature sexual maturation: ◦ <8 years in girls; menarche <11 years ◦ <9 years in boys. • Central precocious puberty or gonadotropin-dependent precocious puberty: ◦ hormone secretion is similar to normal puberty ◦ may be idiopathic, genetic, or secondary to central nervous system/pituitary tumour or insult ◦ treatment is with gonadotropin-releasing hormone analogues. • Gonadotropin-independent precocious puberty (independent source of sex steroid, e.g. gonadal tumour): ◦ treatment should address the primary cause. • Late puberty: ◦ pubertal events within the later normal range. • Delayed onset of puberty: ◦ absence of secondary sexual characteristics: ■ >13 years in a girl ■ >14 years in a boy • Central causes (low follicle-stimulating hormone (FSH)/luteinizing hormone (LH)): ◦ chronic illness ◦ eating disorders ◦ physiological ◦ hypogonadotropic hypogonadism. • Peripheral causes (high FSH/LH): ◦ gonadal dysgenesis including chromosomal syndromes, e.g. Turner, Klinefelter ◦ gonadal damage including cancer treatments. • Treatment: ◦ low-dose sex hormone to induce growth and secondary sexual characteristics ◦ recombinant FSH/LH to induce fertility potential.

scholarly journals Adolescent Girls with Pure Gonadal Dysgenesis: A Rare Disease

2018 ◽  
Vol 36 (4) ◽  
pp. 170-174
Author(s):  
Joysree Saha ◽  
Kohinoor Begum ◽  
Kamil Ara Khanom ◽  
Indrajit Prasad ◽  
Sumaya Akter
Keyword(s):  
Gonadal Dysgenesis ◽  
Ovarian Function ◽  
Sensorineural Deafness ◽  
Pubic Hair ◽  
Primary Amenorrhoea ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Patient Will ◽  
History Of ◽  
Secondary Sexual

Gonadal dysgenesis is a rare cause of primary amenorrhoea ,which is a relatively common problem among teenage girls.Primary amenorrhoea occurs in patient with gonadal dysgenesis because of absence or limited ovarian function due to inappropriate development.Streak gonads are unable to produce estrogens and/or androgens,resulting in minimal to no development of secondary sexual characteristics.Adrenal androgens may induce production of pubic hair,but patient will have minimal breast development.These patients may have a family history of infertility, short stature,sensorineural deafness,ataxia,mild mental retardation or gonadoblastoma. Here two cases of primary amenorrhoea due to pure gonadal dysgenesis are presented. 1 st  one was a 18yr old girl whose mother consulted with a gynaecologist at the age of 16yr because of her worries about absence of menarche of her daughter and secondone was a 14yr old girl whose mother consulted with a gynaecologist at the age of 16yr because of absence of secondary sexual characteristics as well as menarche of her daughter. In both cases, blood test showed very high levels of follicle stimulating hormone (FSH) & luteinizing hormone (LH), low levels of oestradiol& very low level of AMH. USG findings of both cases showed a bit hypoplastic uterus and volume of ovaries were smaller than normal. A diagnostic laparoscopy with biopsy of both gonads of one case was performed.Another case did not give consent for laparoscopy.Hormonal replacement therapy was applied on them for establishment of normal menstruation and menstruation was established in both cases.  An early diagnosis is extremely important to prevent long term consequences of Gonadal dysgenesis.J Bangladesh Coll Phys Surg 2018; 36(4): 170-174

scholarly journals Case Report: Cerebral leukodystrophy and the gonadal endocrinopathy: a rare but real association

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 158
Author(s):  
Mohammad Humayun ◽  
Abidullah Khan
Keyword(s):  
Initiation Factor ◽  
Ovarian Insufficiency ◽  
Mri Scan ◽  
Her Family ◽  
Secondary Sexual Characteristics ◽  
Pakistani Woman ◽  
Sexual Characteristics ◽  
History Of ◽  
The Brain ◽  
Vanishing White Matter

A 30 year old married Pakistani woman presented in January 2018 with an eight month history of progressive left sided weakness, ataxia, spasticity, underdeveloped secondary sexual characteristics and primary infertility. She was the elder sister of a 19 year old bed bound woman who was diagnosed with vanishing white matter (VWM) disease 12 months previously. The MRI scan of the brain  demonstrated diffuse leukodystrophy and her hormonal assays were significant for premature ovarian insufficiency. Results from her genetic tests demonstrated a point mutation in eukaryotic initiation factor 2B (EIF2B). Thus, she was the second confirmed case of  VWM from her  family of 12 siblings with normal parents.

scholarly journals Central Precocious Puberty in Boys and Girls: Similarities and Differences

Sexes ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 119-131
Author(s):  
Cristina Mucaria ◽  
Nina Tyutyusheva ◽  
Giampiero I. Baroncelli ◽  
Diego Peroni ◽  
Silvano Bertelloni
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Bone Age ◽  
Gnrh Analog ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
The Central Nervous System

Central precocious puberty (CPP) is due to the premature activation of the hypothalamic–pituitary–gonadal axis, which is responsible for the appearance of secondary sexual characteristics. It occurs before the age of 8 and 9 in girls and boys, respectively. CPP shows higher incidence in females than in males. Causes of CPP are similar in both sexes, but the idiopathic form is more frequent in girls, while organic forms are more frequent in males. Recent studies demonstrated a role of some genetic variants in the pathogenesis of CPP. The diagnostic evaluation based on accurate physical examination, assessment of the pituitary–gonadal axis, pelvic sonography in girls, and determination of bone age. Magnetic resonance of the central nervous system should be done in all boys and selected girls. Since the 1980s, pharmacologic treatment involves the use of gonadotropin-releasing hormone (GnRH) analogs. These drugs are characterized by few side effects and long-term safety. Many data are available on the outcome of GnRH analog treated female patients, while poor data are reported in boys. Adult height is improved in both sexes.

Association study of LIN28B in girls with precocious puberty

2017 ◽  
Vol 30 (6) ◽  
Author(s):  
Yen-Chun Chen ◽  
Li-Min Chen ◽  
Hung-Hsun Lin ◽  
Bai-Hsiun Chen ◽  
Mei-Chyn Chao ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Standard Deviation Score ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Nucleotide Polymorphisms ◽  
Dominant Trait ◽  
Single Nucleotide ◽  
Secondary Sexual Characteristics ◽  
Genotype Frequencies ◽  
Sexual Characteristics

AbstractBackground:Central precocious puberty (CPP), predominant in girls, is defined by early development of secondary sexual characteristics driven by the early secretion of hypothalamic gonadotropin releasing hormone (GnRH) and subsequent gonadotropin. Recent studies have shown variation in theMethods:This study attempted to investigate the relation between single-nucleotide polymorphisms (SNPs) inResults:We found genotype frequencies in rs314276 and rs221634 were significantly correlated with girls with CPP; while the C allele frequency in rs314276 showed the dominant trait. Standard deviation score (SDS) of weight and body mass index (BMI) were higher in CC homozygotes of rs314276 in girls with CPP.Conclusions:Our results demonstrate that the genotype of rs314276 in

scholarly journals Heptoblastoma as a Rare Cause of Precocious Puberty

1970 ◽  
Vol 1 (2) ◽  
pp. 28-32
Author(s):  
Md Abu Taher ◽  
AHM Abdul Fattah ◽  
Dilruba Khandker ◽  
Abu Saleh Mohiuddin ◽  
Md Mahfuzar Rahman ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Histopathological Examination ◽  
Ambiguous Genitalia ◽  
Adrenal Tumors ◽  
Imaging Features ◽  
Adrenal Hyperplasia ◽  
Testicular Tumors ◽  
Primary Liver Tumor ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics

A 15-month old boy presented with an abdominal swelling and early development of secondary sexual characteristics for the last 5 months. The mass was initially suspected to be of adrenal origin. Radiological and biochemical (hormonal) findings diagnosed the case to be a hepatoblastoma later confirmed by histopathological examination. Hepatoblastoma, an aggressive primary liver tumor, is a rare form of childhood malignancy and a rare cause of precocious puberty compared to the more common adrenal causes including congenital adrenal hyperplasia, adrenal tumors and the testicular tumors. Thus, when virilization occurs postnatally in boys, or girls presenting with ambiguous genitalia at birth, a virilizing adrenocortical tumor is usually given the first consideration (according to its frequency of incidence), followed by CNS causes. Rarely does one think of the other possibilities. This report describes the typical presentations and clinical features of hepatoblastoma highlighting its usual radiological features. Ibrahim Med. Coll. J. 2007; 1(2): 28-32 Key Words: Hepatoblastoma, precocious puberty, imaging features.   doi: 10.3329/imcj.v1i2.2907  

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