Physicochemical Properties and Field Evaluation of Monolithic Wax Formulations for the Controlled Release of a Forest Pest Pheromone

Resveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.

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Nicardipine Loaded Solid Phospholipid Extrudates for the Prevention of Cerebral Vasospasms: In Vitro Characterization

Pharmaceutics ◽

10.3390/pharmaceutics12090817 ◽

2020 ◽

Vol 12 (9) ◽

pp. 817 ◽

Cited By ~ 1

Author(s):

Christin Zlomke ◽

Johannes Albrecht ◽

Karsten Mäder

Keyword(s):

Controlled Release ◽

Physicochemical Properties ◽

Texture Analysis ◽

Phospholipid Composition ◽

Twin Screw Extrusion ◽

In Vitro Characterization ◽

Screw Extrusion ◽

Twin Screw

The aim of the study was to develop nicardipine loaded phospholipid extrudates as an alternative for PLA/PLGA-based implants for the prevention of cerebral vasospasms. Extrudates of different mixtures of saturated and unsaturated phosphatidylcholine (PC) were produced and characterized by DSC, microscopy and texture analysis. Single phospholipid components were identified by ELSD-HPLC. Extrudates of 2 mm diameter were obtained by twin screw extrusion temperatures below 50 °C. The ratio of unsaturated and saturated phosphatidylcholine components determines the physicochemical properties of the extrudates as well as the rate of erosion. Nicardipine loaded phospholipids extrudates released the drug over several weeks in vitro. The phospholipid composition of the remaining extrudate changed during the release, the content of unsaturated phospholipids decreased faster compared to the saturated ones. In conclusion, solid phospholipid extrudates are promising materials for the development of new parenteral controlled release systems.

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Redox-responsive PAEFc- b -PDMAEMA amphiphilic block copolymer self-assembly micelles: Physicochemical properties and anticancer drug controlled release

Journal of Industrial and Engineering Chemistry ◽

10.1016/j.jiec.2016.12.021 ◽

2017 ◽

Vol 48 ◽

pp. 66-78 ◽

Cited By ~ 11

Author(s):

Yuan Wang ◽

Yan-Ling Luo ◽

Feng Xu ◽

Ya-Shao Chen ◽

Wei Tang

Keyword(s):

Controlled Release ◽

Block Copolymer ◽

Physicochemical Properties ◽

Anticancer Drug ◽

Self Assembly ◽

Amphiphilic Block Copolymer ◽

Drug Controlled Release ◽

Redox Responsive

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Further field evaluation of the controlled release nitrogen fertiliser Smartfert®

Journal of New Zealand Grasslands ◽

10.33584/jnzg.2017.79.539 ◽

2017 ◽

Vol 79 ◽

pp. 73-78

Author(s):

D.C. Edmeades ◽

R.M. Mcbride

Keyword(s):

Controlled Release ◽

Field Evaluation ◽

Field Trials ◽

Total Production ◽

Single Application ◽

Pasture Production ◽

Nitrogen Fertiliser ◽

The Third ◽

N Concentration

Five field trials were conducted over 2 years in which the effects of single applications of different rates of a controlled release nitrogen (N) fertiliser, Smartfert, on pasture production and pasture N concentration were measured, relative to the same rates of SustaiN. The 2016 trials also compared multiple applications of SustaiN with a single application of Smartfert. Pasture responses to SustaiN relative to the control generally occurred within the first one to three harvests following application and then declined and became negative in the later harvests. The pasture responses to Smartfert developed more slowly and were greatest after the third harvest. In terms of total production significant (P

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