scholarly journals Oral dydrogesterone vs. vaginal progesterone capsules for luteal-phase support in women undergoing embryo transfer: a systematic review and meta-analysis

2018 ◽  
Author(s):  
Marina Wanderley Paes Barbosa ◽  
Natália Paes Barbosa Valadares ◽  
Antônio César Paes Barbosa ◽  
Adelino Silva Amaral ◽  
José Rubens Iglesias ◽  
...  
Keyword(s):  
Systematic Review ◽  
Embryo Transfer ◽  
Luteal Phase ◽  
Meta Analysis ◽  
Luteal Phase Support ◽  
Vaginal Progesterone

scholarly journals Dydrogesterone as an oral alternative to vaginal progesterone for IVF luteal phase support: A systematic review and individual participant data meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241044
Author(s):  
Georg Griesinger ◽  
Christophe Blockeel ◽  
Elke Kahler ◽  
Claire Pexman-Fieth ◽  
Jan I. Olofsson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Luteal Phase ◽  
Meta Analysis ◽  
Individual Participant Data ◽  
Luteal Phase Support ◽  
Vaginal Progesterone ◽  
Individual Participant

scholarly journals Efficacy of luteal phase support with vaginal progesterone in intrauterine insemination: a systematic review and meta-analysis

2013 ◽  
Vol 31 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Ester Miralpeix ◽  
Mireia González-Comadran ◽  
Ivan Solà ◽  
Dolors Manau ◽  
Ramon Carreras ◽  
...  
Keyword(s):  
Systematic Review ◽  
Luteal Phase ◽  
Intrauterine Insemination ◽  
Meta Analysis ◽  
Luteal Phase Support ◽  
Vaginal Progesterone

scholarly journals Effect of luteal phase support with vaginal progesterone on pregnancy outcomes in natural frozen embryo transfer cycles: A meta-analysis

2020 ◽  
Vol 47 (2) ◽  
pp. 147-152
Author(s):  
Aeran Seol ◽  
Yoo Jin Shim ◽  
Sung Woo Kim ◽  
Seul Ki Kim ◽  
Jung Ryeol Lee ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Luteal Phase ◽  
Selection Criteria ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Frozen Embryo Transfer ◽  
Cochrane Library ◽  
Luteal Phase Support ◽  
Vaginal Progesterone ◽  
Significant Difference

Objective: The purpose of this study was to determine the effect of vaginal progesterone for luteal phase support (LPS) on the clinical pregnancy rate (CPR) in natural frozen embryo transfer (FET) cycles via a meta-analysis.Methods: We performed a meta-analysis of randomized controlled trials (RCTs) and retrospective studies that met our selection criteria. Four online databases (PubMed, Embase, Medline, and the Cochrane Library) were searched between January 2017 and May 2017. Studies were selected according to predefined inclusion criteria and meta-analyzed using R software version 2.14.2. The main outcome measure was CPR.Results: A total of 18 studies were reviewed and assessed for eligibility. One RCT (n=435) and three retrospective studies (n=3,033) met the selection criteria. In a meta-analysis of the selected studies, we found no significant difference in the CPR (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.60–1.55) between the vaginal progesterone and control groups. An analysis of the two retrospective cohort studies that reported the live birth rate (LBR) following FET showed a significantly higher LBR in the vaginal progesterone group (OR, 1.72; 95% CI, 1.21–2.46). A subgroup meta-analysis of FET conducted 5 days after injection of human chorionic gonadotropin showed no significant differences between the two groups with regard to the CPR (OR, 1.18; 95% CI, 0.90–1.55) or miscarriage rate (OR, 0.73; 95% CI, 0.36–1.47).Conclusion: The results of this meta-analysis of the currently available literature suggest that LPS with vaginal progesterone in natural FET cycles does not improve the CPR.

scholarly journals Subcutaneous progesterone versus vaginal progesterone for luteal-phase support in frozen-thawed embryo transfer: A cross-sectional study

2021 ◽  
Author(s):  
Abbas Aflatoonian ◽  
Banafsheh Mohammadi
Keyword(s):  
Embryo Transfer ◽  
Luteal Phase ◽  
Cross Sectional Study ◽  
Clinical Pregnancy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Luteal Phase Support ◽  
Vaginal Progesterone ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

Background: Luteal-phase support is a complex and controversial issue in the field of reproductive management. Objective: To compare the safety and efficacy of low-dose subcutaneous progesterone with the vaginal progesterone for luteal-phase support in patients undergoing rozenthawed embryo transfer. Materials and Methods: In this cross-sectional study, information related to 77 women that had frozen-thawed embryo transfer was reviewed. The patients were divided into two groups based on the route of progesterone administration used as a luteal-phase support. When the endometrial thickness reached ≥ 8 mm, in one group progesterone (Prolutex) 25 mg/ daily subcutaneous and in another group, vaginal progesterone (Cyclogest®) 400 mg twice or (Endometrin®) 100 mg thrice daily, were administrated and continued until menstruation or in case of clinical pregnancy for 8 wk after the embryo transfer when the fetal heart activity was detected by ultrasonography. Results: The patient’s characteristics were matched and there was no significant difference. The chemical and clinical pregnancy rate was higher in the vaginal progesterone group compared to the prolutex group, but statistically unnoticeable, (40% vs. 29.6%, p = 0.367) and (28% vs. 22.2%, p = 0.581), respectively. C Conclusion: The findings of this study demonstrate that the new subcutaneous progesterone can be a good alternative for intramuscular progesterone in women that dislike and do not accept vaginal formulations as luteal-phase support in assisted reproductive technology. Key words: Progesterone, Subcutaneous, Vaginal, Pregnancy.

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