scholarly journals Investigation the influence of mechanochemical processing on solubility of verapamil hydrochloride

Tehnika ◽  
2021 ◽  
Vol 76 (1) ◽  
pp. 9-14
Author(s):  
Ana Stanković ◽  
Sonja Jovanović
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Morphological Characteristics ◽  
Pharmaceutical Products ◽  
Mechanochemical Treatment ◽  
Full Potential ◽  
Verapamil Hydrochloride ◽  
Vis Spectroscopy ◽  
The Impact

Dissolution of drugs is a very important factor that directly affects their potential application. Due to the fact that solubility may act as a limiting factor in the process of absorption of the drug, it can also affect its bio-availableness. More than 40 percent of potential drugs have a property of a poor solubility in the water, resulting in potentially important pharmaceutical products not reaching patients or reaching their full potential. This work examined the possibility of improving the solubility of verapamil hydrochloride (VHCl) by applying mechanochemical treatment. The impact of mechanochemical treatment on physiochemical properties was comprehended by applying XRPD, FTIR and Raman spectroscopy, as well as FESEM analysis. Besides, particle size distribution was determined. Solubility of verapamil hydrochloride was determined by using UV-VIS spectroscopy. Finally, the solubility of verapamil hydrochloride was correlated with particle size distribution, structural and morphological characteristics.

scholarly journals Green Preparation, Spheroidal, and Superior Property of Nano-1,3,5,7-Tetranittro-1,3,5,7-Tetrazocane

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Xinlei Jia ◽  
Jingyu Wang ◽  
Conghua Hou ◽  
Yingxin Tan
Keyword(s):  
Activation Energy ◽  
Particle Size ◽  
Fractal Dimension ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Fractal Theory ◽  
Crystal Form ◽  
Decomposition Temperature ◽  
Scanning Calorimetry ◽  
The Impact

Herein, a green process for preparing nano-HMX, mechanical demulsification shearing (MDS) technology, was developed. Nano-HMX was successfully fabricated via MDS technology without using any chemical reagents, and the fabrication mechanism was proposed. Based on the “fractal theory,” the optimal shearing time for mechanical emulsification was deduced by calculating the fractal dimension of the particle size distribution. The as-prepared nano-HMX was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). And the impact sensitivities of HMX particles were contrastively investigated. The raw HMX had a lower fractal dimension of 1.9273. The ideal shearing time was 7 h. The resultant nano-HMX possessed a particle size distribution ranging from 203.3 nm to 509.1 nm as compared to raw HMX. Nano-HMX particles were dense spherical, maintaining β-HMX crystal form. In addition, they had much lower impact sensitivity. However, the apparent activation energy as well as thermal decomposition temperature of nano-HMX particles was decreased, attributing to the reduced probability for hotspot generation. Especially when the shearing time was 7 h, the activation energy was markedly decreased.

Influence of Fuel in the Synthesis of ZnAl2O4 Catalytic Supports by Combustion Reaction

2010 ◽  
Vol 660-661 ◽  
pp. 52-57 ◽  
Author(s):  
Kaline Melo de Souto Viana ◽  
Bruno Brito Dantas ◽  
N.A.S. Nogueira ◽  
J.M. Sasaki ◽  
Normanda Lino de Freitas ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Crystallite Size ◽  
Size Distribution ◽  
Spinel Structure ◽  
Morphological Characteristics ◽  
Combustion Reaction ◽  
Nanosized Particles ◽  
Catalytic Supports ◽  
Stoichiometric Proportion

The aim of this work is to evaluate the influence of fuel in the synthesis of ZnAl2O4 catalytic supports by combustion reaction. For this, it was used the fuels: urea, carbohidrazide, glycine and aniline. The total amount of reagents was calculated according to the theory of propellants and explosive using urea in the stoichiometric proportion (Φe = 1). The structural and morphological characteristics of the powders were evaluated by XRD, FTIR, TEM, SEM and particle size distribution. The results from XRD showed the formation of the normal cubic spinel structure. The powders presented nanosized particles with narrow agglomerates size distribution. The powders prepared with urea showed better value of surface area and smaller crystallite size.

scholarly journals Relationship between Particle Size Distribution of Low-Rank Pulverized Coal and Power Plant Performance

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Rajive Ganguli ◽  
Sukumar Bandopadhyay
Keyword(s):  
Particle Size ◽  
Power Plant ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Power Plants ◽  
Pulverized Coal ◽  
Plant Performance ◽  
Low Rank ◽  
Volatile Content ◽  
The Impact

The impact of particle size distribution (PSD) of pulverized, low rank high volatile content Alaska coal on combustion related power plant performance was studied in a series of field scale tests. Performance was gauged through efficiency (ratio of megawatt generated to energy consumed as coal), emissions (SO2,NOx, CO), and carbon content of ash (fly ash and bottom ash). The study revealed that the tested coal could be burned at a grind as coarse as 50% passing 76 microns, with no deleterious impact on power generation and emissions. The PSD’s tested in this study were in the range of 41 to 81 percent passing 76 microns. There was negligible correlation between PSD and the followings factors: efficiency, SO2,NOx, and CO. Additionally, two tests where stack mercury (Hg) data was collected, did not demonstrate any real difference in Hg emissions with PSD. The results from the field tests positively impacts pulverized coal power plants that burn low rank high volatile content coals (such as Powder River Basin coal). These plants can potentially reduce in-plant load by grinding the coal less (without impacting plant performance on emissions and efficiency) and thereby, increasing their marketability.

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