Background:
This review investigates the ophthalmic drugs that have been studied with
voltammetry in the web of science database in the last 10 years.
Introduction:
Ophthalmic drugs are used in the diagnosis, evaluation and treatment of various ophthalmological
diseases and conditions. A significant literature has emerged in recent years that investigates
determination of these active compounds via electroanalytical methods, particularly voltammetry. Low
cost, rapid determination, high availability, efficient sensitivity and simple application make voltammetry
one of the most used methods for determining various kinds of drugs including ophthalmic ones.
Methods:
In this particular review, we searched the literature via the web of science database for ophthalmic
drugs which are investigated with voltammetric techniques using the keywords of voltammetry,
electrochemistry, determination and electroanalytical methods.
Results:
We found 33 types of pharmaceuticals in nearly 140 articles. We grouped them clinically into
seven major groups as antibiotics, antivirals, non-steroidal anti-inflammatory drugs, anti-glaucomatous
drugs, steroidal drugs, local anesthetics and miscellaneous. Voltammetric techniques, electrodes, optimum
pHs, peak potentials, limit of detection values, limit of quantification values, linearity ranges,
sample type and interference effects were compared.
Conclusion:
Ophthalmic drugs are widely used in the clinic and it is important to determine trace
amounts of these species analytically. Voltammetry is a preferred method for its ease of use, high sensitivity,
low cost, and high availability for the determination of ophthalmic drugs as well as many other
medical drugs. The low limits of detection values indicate that voltammetry is quite sufficient for determining
ophthalmic drugs in many media such as human serum, urine and ophthalmic eye drops.