Serum Levels of Oxidative Stress Biomarkers in Patients Obsessive Compulsive Disorder in Tikrit City, Iraq

Background: Oxidative stress may play an important role in the pathogenesis of pulmonary tuberculosis (PTB). To our knowledge there is paucity of data on the status of oxidative stress biomarkers among PTB patients in Gombe, North-eastern Nigeria. Our study was designed to evaluate the oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria. Aims and Objectives: To determine the serum levels of oxidative stress biomarkers among patients with pulmonary tuberculosis in Gombe metropolis, North-eastern Nigeria and to assess the correlation between the oxidative stress biomarkers in pulmonary tuberculosis patients. Materials and Methods: A cross sectional comparative study was conducted in a tertiary health care facility with 40 pulmonary tuberculosis (PTB) patients on anti-TB drugs treatment (ATT), 40 newly diagnosed PTB patients not yet on anti-TB drugs treatment (ATT-naïve) and 40 age- and sex-marched apparently healthy subjects (controls). Serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), nitric oxide (NO) and oxidative stress index (OSI) determined using standard techniques. Data was analysed using INSTAT® (Graph Pad Software Inc., La Jolla, CA, USA). Results: Serum levels of TOS, OSI, MDA and NO were significantly (p ˂ 0.001) increased in PTB patients (ATT and ATT-naïve) when compared with healthy individuals. Serum TAS and body mass index (BMI) were significantly (p ˂ 0.001) decreased in PTB patients when compared with healthy individuals. Serum TOS significantly correlated with serum OSI, MDA and NO in ATT-naïve PTB patients. Conclusion: This study observed an increased oxidative stress biomarkers and decreased total antioxidant status in newly diagnosed pulmonary tuberculosis patients and those on treatment. Our findings suggest that antioxidants supplementation and improved nutrition in the management of pulmonary tuberculosis patients may go a long way in preventing the oxidative onslaught and further complications in PTB patients.

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Study of oxidative stress in obsessive compulsive disorder in response to treatment with Fluoxetine

Indian Journal of Clinical Biochemistry ◽

10.1007/s12291-009-0035-9 ◽

2009 ◽

Vol 24 (2) ◽

pp. 194-197 ◽

Cited By ~ 11

Author(s):

Sutirtha Chakraborty ◽

Anindya Dasgupta ◽

Harendra Nath Das ◽

Om Prakash Singh ◽

Asok Kumar Mandal ◽

...

Keyword(s):

Oxidative Stress ◽

Obsessive Compulsive Disorder ◽

Response To Treatment ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Vitamin B12and folic acid serum levels in obsessive compulsive disorder

Acta Psychiatrica Scandinavica ◽

10.1111/j.1600-0447.1988.tb06294.x ◽

1988 ◽

Vol 78 (1) ◽

pp. 8-10 ◽

Cited By ~ 11

Author(s):

H. Hermesh ◽

A. Weizman ◽

A. Shahar ◽

H. Munitz

Keyword(s):

Folic Acid ◽

Obsessive Compulsive Disorder ◽

Serum Levels ◽

Obsessive Compulsive ◽

Compulsive Disorder

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The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

10.21203/rs.3.rs-1158115/v1 ◽

2021 ◽

Author(s):

Amir Hossein Mohammadi ◽

Ebrahim Balandeh ◽

Jila Hasani ◽

Mohammad Karimian ◽

Morteza Pourfarzam ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin A ◽

Atpase Activity ◽

Obsessive Compulsive Disorder ◽

Serum Vitamin ◽

Reversed Phase ◽

Lower Activity ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Rbc Membrane

Abstract Background: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including MDA levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E) and Na+/K+-ATPase activity in patients with the mentioned disorder vs. healthy controls.Method: 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and 39 volunteers’ healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorimetric method. Serum TAC level, serum GSH level and Na+/K+-ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by Reversed-phase high-performance liquid chromatography (RP-HPLC).Result: There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.024) and vitamin E (p=0.001) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na+-K+ ATPase in RBC membrane of OCD patients vs. controls (p<0.0001).Conclusion: Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamin A and E, and lower activity of membrane Na+-K+ ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD.

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The Role of Antioxidants in the Management of Obsessive-Compulsive Disorder

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/6661514 ◽

2021 ◽

Vol 2021 ◽

pp. 1-15

Author(s):

Fatemeh Baratzadeh ◽

Sepideh Elyasi ◽

Amir Hooshang Mohammadpour ◽

Sofia Salari ◽

Amirhossein Sahebkar

Keyword(s):

Oxidative Stress ◽

Obsessive Compulsive Disorder ◽

Selective Serotonin Reuptake Inhibitors ◽

Human Studies ◽

Large Sample Size ◽

Antioxidant Treatment ◽

Obsessive Compulsive ◽

Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder that has a significant effect on the quality of life. The most effective treatment for OCD is the combination of selective serotonin reuptake inhibitors (SSRI) with cognitive behavior therapy (CBT). However, several adverse effects have been linked with this usual pharmacotherapy, and it is unsuccessful in many patients. The exact pathophysiology of OCD is not completely known, though the role of oxidative stress in its pathogenesis has been proposed recently. This review presents an overview of animal and human studies of antioxidant treatment for OCD. The use of antioxidants against oxidative stress is a novel treatment for several neurodegenerative and neuropsychiatric disorders. Among antioxidants, NAC was one of the most studied drugs on OCD, and it showed a significant improvement in OCD symptoms. Thus, antioxidants could be promising as an adjuvant treatment for OCD. However, a limited number of human studies are conducted on these agents, and for better judgment, human studies with a large sample size are necessary.

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Changes of Nitric Oxide and Peroxynitrite Serum Levels during Drug Therapy in Patients with Obsessive-Compulsive Disorder

Advances in Medicine ◽

10.1155/2016/9131680 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Leila Kouti ◽

Mehdi Sayyah ◽

Parisa Mosallanezhad ◽

Sara Kooti ◽

Maryam Aghakoochakzadeh ◽

...

Keyword(s):

Nitric Oxide ◽

Drug Therapy ◽

Obsessive Compulsive Disorder ◽

Selective Serotonin Reuptake Inhibitors ◽

Serum Levels ◽

Response To Therapy ◽

Augmentation Therapy ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Effect Of Treatment

Objectives. Some studies have shown that increased nitric oxide (NO) concentrations may be associated with obsessive-compulsive disorder (OCD). In a few animal researches, enhanced synthesis of NO had reversed the effect of selective serotonin reuptake inhibitors (SSRIs). The present study tries to find the effect of treatment with SSRIs on NO serum levels and its product peroxynitrite.Patients and Methods. Patients diagnosed with OCD who are candidates of receiving SSRIs entered this study. Two blood samples were taken from subjects, prior to drug therapy and after the patients had shown some improvements due to their regimen. Serum NO and peroxynitrite levels were measured and their correlation with SSRI use was assessed.Results. 31 patients completed this study. Mean concentrations of NO and peroxynitrite prior to drug therapy were28.63±16.9and5.73±2.5 μmol/L, respectively. These values were 18.87±7.55and2.15±0.94 μmol/L at the second blood test. Withpvalues < 0.05, these differences were considered significant.Conclusion. Patients, who showed improvement of OCD symptoms after a mean duration of SSRI monotherapy of3.531±0.64months, had lower values of NO and peroxynitrite in their sera compared to their levels prior to therapy. Such results can be helpful in finding a predictive factor of response to therapy and augmentation therapy with future drugs that target NO synthesis.

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