The molecular complexes of the monoammonium salt of glycyrrhizic acid with urea, thiourea, methylolthiourea and their fungicidal activity

2021 ◽  
Vol 11 (9) ◽  
pp. 961-968
Author(s):  
Yusup Tojimamatovich Isaev ◽  
Ibragim Raxmanovich Askarov ◽  
Sandjar Ashiralievich Rustamov ◽  
Egamberdiev Doston Usmondjon Ugli ◽  
Xabibjon Xojibekovich Kushiev
Keyword(s):  
Glycyrrhizic Acid ◽  
Fungicidal Activity ◽  
Molecular Complexes

scholarly journals MOLECULAR COMPLEXES OF MONOAMMONIUM SALT OF GLYCYRRHIZIC ACID WITH SOME UREA AND THEIR ANTIBIOTIC ACTIVITY

2021 ◽  
Vol 19 (3) ◽  
pp. 160-167
Author(s):  
Yu.T. Isaev ◽  
◽  
I.R. Askarov ◽  
S.A. Rustamov ◽  
D.U. Egamberdiev ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Fungicidal Activity ◽  
Pathogenic Fungus ◽  
Equilibrium Constants ◽  
Molecular Complexes ◽  
Complex Compounds ◽  
Antibiotic Activity ◽  
Polar Groups ◽  
Ir Spectroscopic ◽  
Complexation Process

This article reports on obtaining the inclusion compounds of the monoammonium-glycyrrhizin salts with urea, thiourea and methylolthiourea. The compounds were obtained by the liquid phase way, and their structures were characterized by the UV- and IR-Spectroscopic methods. Proceeding from the spectral data, it was concluded that the complexation occurs through the interaction of polar groups of the components. The composition of the complexes was studied using the method of isomolar series. Equilibrium constants and changes in Gibbs free energy of the complexation process were also calculated. The biological activity of complex compounds was studied on the example of fungicidal activity of one of the most common pathogenic fungus Fusarium. The obtained compounds can be used as as fungicides and stimulants in agriculture.

Synthesis and study of the fungicidal activity of amine salts of glycyrrhizic acid

2012 ◽  
Vol 38 (7) ◽  
pp. 736-739
Author(s):  
E. A. Dikusar ◽  
V. I. Potkin ◽  
N. G. Kozlov ◽  
R. A. Gadzhily ◽  
R. T. Tlegenov ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Fungicidal Activity ◽  
Amine Salts

scholarly journals Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids

2021 ◽  
Vol 8 (2) ◽  
pp. 20218202
Author(s):  
S. S. Khizrieva ◽  
E. V. Vetrova ◽  
S. N. Borisenko ◽  
E. V. Maksimenko ◽  
N. I. Borisenko
Keyword(s):  
Stability Constant ◽  
Glycyrrhizic Acid ◽  
Antiviral Drug ◽  
Binding Constants ◽  
Molecular Complexes ◽  
High Potential ◽  
The Novel ◽  
Molar Ratios ◽  
Vis Spectroscopy ◽  
First Time

Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery.

Probing massive cold cores discovered by ISO in quiescent galactic molecular complexes

2002 ◽  
Vol 4 ◽  
pp. 133-133
Author(s):  
D. Teyssier ◽  
P. Hennebelle ◽  
M. Pérault
Keyword(s):  
Molecular Complexes

Aktivitas Antifungi Air Perasan Bawang Merah (Allium ascalonicum L.) Terhadap Candida albicans Secara In Vitro

2017 ◽  
Vol 9 (2) ◽  
pp. 71
Author(s):  
Nurhasanah Nurhasanah ◽  
Fauzia Andrini ◽  
Yulis Hamidy
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Allium Sativum ◽  
Fungicidal Activity ◽  
Positive Control ◽  
Negative Control ◽  
Randomized Design ◽  
Significant Difference ◽  
Completely Randomized Design

Shallot (Allium ascalonicum L.) has been known as traditional medicine. Shallot which has same genus with garlic(Allium sativum L.) contains allicin that is also found in garlic and has been suspected has fungicidal activity toCandida albicans. It is supported by several researches. Therefore, shallot is suspected has antifungal activity too.The aim of this research was to know antifungal activity of shallot’s water extortion againsts Candida albicans invitro. This was a laboratory experimental research which used completely randomized design, with diffusion method.Shallot’s water extortion was devided into three concentrations, there were 50%, 100% and 200%. Ketoconazole 2%was positive control and aquadest was negative control. The result of this research based on analysis of varians(Anova), there was significant difference between several treatments and was confirmed with Duncan New MultipleRange Test (DNMRT) p<0,05, there was significant difference between 100% shallot’s water extortion with othertreatments, but there was no significant difference between 50% shallot’s water extortion with 200% shallot’s. Theconclusion was shallot’s water extortion had antifungal activity againsts Candida albicans with the best concentration100%, but it was lower than ketoconazole 2%.

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