NCCN Increases the Emphasis on Genetic/Familial High-Risk Assessment in Colorectal Cancer

2014 ◽  
Vol 12 (5S) ◽  
pp. 829-831 ◽  
Author(s):  
Heather Hampel
Keyword(s):  
Colorectal Cancer ◽  
Risk Assessment ◽  
High Risk ◽  
Lynch Syndrome ◽  
Risk Reduction ◽  
Hereditary Colorectal Cancer ◽  
Clinical Criteria ◽  
New Guidelines ◽  
Familial High Risk

NCCN has developed new guidelines for the assessment of high-risk familial/genetic colorectal cancer, and has positioned these recommendations within the guidelines for detection, prevention, and risk reduction. The Panel recommends that all patients with colorectal cancer be screened for Lynch syndrome, which occurs in 1 of every 35 patients and is the most common form of hereditary colorectal cancer. Such screening could be universal so that all tumors are genetically tested, or screening could be restricted to patients under the age of 70 and those aged 70 and older who meet clinical criteria.

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019

2019 ◽  
Vol 17 (9) ◽  
pp. 1032-1041 ◽  
Author(s):  
Samir Gupta ◽  
Dawn Provenzale ◽  
Xavier Llor ◽  
Amy L. Halverson ◽  
William Grady ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Assessment ◽  
High Risk ◽  
Hereditary Colorectal Cancer ◽  
Cancer Surveillance ◽  
Nccn Guidelines ◽  
Hereditary Syndromes ◽  
Hereditary Colorectal Cancer Syndromes ◽  
Cancer Syndromes ◽  
Familial High Risk

Identifying individuals with hereditary syndromes allows for improved cancer surveillance, risk reduction, and optimized management. Establishing criteria for assessment allows for the identification of individuals who are carriers of pathogenic genetic variants. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide recommendations for the assessment and management of patients with high-risk colorectal cancer syndromes. These NCCN Guidelines Insights focus on criteria for the evaluation of Lynch syndrome and considerations for use of multigene testing in the assessment of hereditary colorectal cancer syndromes.

Application of Multigene Panel Testing In Patients With High Risk for Hereditary Colorectal Cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ji Soo Park ◽  
Jung Won Park ◽  
Saeam Shin ◽  
Seung-Tae Lee ◽  
Sang Joon Shin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Hereditary Colorectal Cancer ◽  
Panel Testing ◽  
Multigene Panel Testing ◽  
Multigene Panel

Risk of Colorectal Cancer After Detection and Removal of Adenomas at Colonoscopy: Population-Based Case-Control Study

2012 ◽  
Vol 30 (24) ◽  
pp. 2969-2976 ◽  
Author(s):  
Hermann Brenner ◽  
Jenny Chang-Claude ◽  
Alexander Rickert ◽  
Christoph M. Seiler ◽  
Michael Hoffmeister
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Risk Reduction ◽  
Large Bowel ◽  
Case Control Study ◽  
Significant Risk ◽  
Population Based ◽  
Case Control ◽  
Odds Ratios ◽  
Control Study

Purpose Empirical evidence for recommendations of surveillance intervals after detection and removal of adenomas at colonoscopy is still sparse and mostly based on observations of adenoma recurrence. We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification. Methods In a population-based case-control study conducted in Germany, detailed history and results of previous large-bowel endoscopies were obtained by interview and from medical records. Risk of CRC among participants with detection of at least one adenoma at a preceding colonoscopy compared with participants without previous large-bowel endoscopy was assessed according to time since polypectomy among 2,582 cases with CRC and 1,798 matched controls. Results Adjusted odds ratios (95% CIs) of CRC for participants with polypectomy less than 3, 3 to 5, and 6 to 10 years ago (using participants without previous endoscopy as reference group) were 0.2 (0.2 to 0.3), 0.4 (0.3 to 0.6), and 0.9 (0.5 to 1.5), respectively. Strong, significant risk reduction within 5 years was consistently seen for women and men, younger and older participants, patients with and without high-risk polyps (three or more polyps, at least one polyp ≥ 1 cm, at least one polyp with villous components), and those with and without polypectomy in the right colon. With adjusted odds ratios of 0.1 (0.1 to 0.2), 0.3 (0.2 to 0.5) and 0.4 (0.2 to 0.8) for patients with polypectomy less than 3, 3 to 5, and 6 to 10 years ago, risk reduction was particularly strong for left-sided CRC. Conclusion Extension of surveillance intervals to 5 years should be considered, even after detection and removal of high-risk polyps.

Increasing Lynch Syndrome Identification Through Establishment of a Hereditary Colorectal Cancer Registry

2013 ◽  
Vol 56 (3) ◽  
pp. 308-314 ◽  
Author(s):  
Duveen Sturgeon ◽  
Tonna McCutcheon ◽  
Timothy M. Geiger ◽  
Roberta L. Muldoon ◽  
Alan J. Herline ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cancer Registry ◽  
Hereditary Colorectal Cancer

T2040 Poor Compliance with MSI-Analysis in Patients with Colorectal Cancer At High Risk for Lynch Syndrome

2008 ◽  
Vol 134 (4) ◽  
pp. A-606
Author(s):  
Margot G. van Lier ◽  
J. de Wilt ◽  
J. Wagemakers ◽  
W. Dinjens ◽  
R. Damhuis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Lynch Syndrome ◽  
Poor Compliance ◽  
Msi Analysis

scholarly journals Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer--the DNA microarray assay.

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Zoran Stojcev ◽  
Tomasz Banasiewicz ◽  
Michał Kaszuba ◽  
Adam Sikorski ◽  
Marek Szczepkowski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
High Risk ◽  
Genetic Screening ◽  
Dna Microarrays ◽  
Risk Group ◽  
Cost Effective ◽  
High Risk Group ◽  
Hereditary Colorectal Cancer ◽  
Detection Of Mutations

Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.

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