scholarly journals Dl-3-n-butylphthalide prevents the disruption of blood-spinal cord barrier via inhibiting endoplasmic reticulum stress following spinal cord injury

2017 ◽  
Vol 13 (12) ◽  
pp. 1520-1531 ◽  
Author(s):  
Binbin Zheng ◽  
Yulong Zhou ◽  
Hongyu Zhang ◽  
Guangyong Yang ◽  
Zhenghua Hong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier

scholarly journals Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury

2021 ◽  
Vol 9 ◽  
Author(s):  
Chongan Huang ◽  
Weiqi Zhang ◽  
FeiFan Chu ◽  
Hao Qian ◽  
Yining Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neurological Deficits ◽  
Critical Event ◽  
Neuroprotective Effects ◽  
Patchouli Alcohol ◽  
Cord Injury ◽  
Blood Spinal Cord Barrier

Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis in vitro. Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.

Deletion of Endoplasmic Reticulum Stress-Induced CHOP Protects Microvasculature Post-Spinal Cord Injury

2012 ◽  
Vol 9 (4) ◽  
pp. 274-281 ◽  
Author(s):  
Janelle M. Fassbender ◽  
Sujata Saraswat-Ohri ◽  
Scott A. Myers ◽  
Mark J. Gruenthal ◽  
Richard L. Benton ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cord Injury

Necrostatin-1 Mitigates Endoplasmic Reticulum Stress After Spinal Cord Injury

2017 ◽  
Vol 42 (12) ◽  
pp. 3548-3558 ◽  
Author(s):  
Shuang Wang ◽  
Jin Wu ◽  
Yu-Zhe Zeng ◽  
Song-Song Wu ◽  
Guo-Rong Deng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cord Injury
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