scholarly journals Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease

2019 ◽  
Vol 15 (9) ◽  
pp. 1955-1961
Author(s):  
Lefeng Wang ◽  
Weiqiang Lin ◽  
Jianghua Chen
Keyword(s):  
Kidney Disease ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

scholarly journals Connexin‐mediated cell communication in the kidney: A potential therapeutic target for future intervention of diabetic kidney disease?

2020 ◽  
Vol 105 (2) ◽  
pp. 219-229 ◽  
Author(s):  
Gareth W. Price ◽  
Joe A. Potter ◽  
Bethany M. Williams ◽  
Chelsy L. Cliff ◽  
Paul E. Squires ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Therapeutic Target ◽  
Diabetic Kidney Disease ◽  
Cell Communication ◽  
Potential Therapeutic Target ◽  
Diabetic Kidney

scholarly journals Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Shilu Luo ◽  
Ming Yang ◽  
Hao Zhao ◽  
Yachun Han ◽  
Na Jiang ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Kidney Disease ◽  
Stress Responses ◽  
Therapeutic Target ◽  
Kidney Diseases ◽  
Cellular Metabolism ◽  
Metabolic Reprogramming ◽  
Potential Therapeutic Target ◽  
Caveolin 1 ◽  
Main Component

The kidney is an energy-consuming organ, and cellular metabolism plays an indispensable role in kidney-related diseases. Caveolin-1 (Cav-1), a multifunctional membrane protein, is the main component of caveolae on the plasma membrane. Caveolae are represented by tiny invaginations that are abundant on the plasma membrane and that serve as a platform to regulate cellular endocytosis, stress responses, and signal transduction. However, caveolae have received increasing attention as a metabolic platform that mediates the endocytosis of albumin, cholesterol, and glucose, participates in cellular metabolic reprogramming and is involved in the progression of kidney disease. It is worth noting that caveolae mainly depend on Cav-1 to perform the abovementioned cellular functions. Furthermore, the mechanism by which Cav-1 regulates cellular metabolism and participates in the pathophysiology of kidney diseases has not been completely elucidated. In this review, we introduce the structure and function of Cav-1 and its functions in regulating cellular metabolism, autophagy, and oxidative stress, focusing on the relationship between Cav-1 in cellular metabolism and kidney disease; in addition, Cav-1 that serves as a potential therapeutic target for treatment of kidney disease is also described.

Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?

2018 ◽  
Vol 130 ◽  
pp. 152-163 ◽  
Author(s):  
Marinaldo Pacífico Cavalcanti Neto ◽  
Jailane de Souza Aquino ◽  
Larissa de Fátima Romão da Silva ◽  
Ruanniere de Oliveira Silva ◽  
Keyth Sulamitta de Lima Guimarães ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Gut Microbiota ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Cardiometabolic Disorders

Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation

2014 ◽  
Vol 127 (1) ◽  
pp. 19-31 ◽  
Author(s):  
Matilde Alique ◽  
Esther Civantos ◽  
Elsa Sanchez-Lopez ◽  
Carolina Lavoz ◽  
Sandra Rayego-Mateos ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Angiotensin Ii ◽  
Kidney Disease ◽  
Therapeutic Target ◽  
Clinical Treatment ◽  
Renal Diseases ◽  
Potential Therapeutic Target ◽  
Renal Inflammation ◽  
Integrin Linked Kinase

There is no effective clinical treatment for chronic kidney disease. We describe in the present paper that ILK (integrin-linked kinase) is a critical regulator of AngII (angiotensin II)-mediated renal inflammation, suggesting that ILK could be a potential therapeutic target for inflammatory renal diseases.

scholarly journals Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yu Yang ◽  
Hui Huang ◽  
Zheng Xu ◽  
Jun-kai Duan
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Therapeutic Target ◽  
Diabetic Kidney Disease ◽  
Vascular Complications ◽  
Controlled Clinical Trials ◽  
Potential Therapeutic Target ◽  
Diabetic Kidney ◽  
Diabetic Vascular Complications ◽  
Physiological Pathways

Diabetic kidney disease (DKD) is a widespread chronic microvascular complication of diabetes mellitus (DM), affects almost 30–50% of patients, and represents a leading cause of death of DM. Serotonin or 5-hydroxytryptamine (5-HT) is a multifunctional bioamine that has crucial roles in many physiological pathways. Recently, emerging evidence from experimental and clinical studies has demonstrated that 5-HT is involved in the pathogenesis of diabetic vascular complications. The 5-HT receptor (5-HTR) antagonists exert renoprotective effects by suppressing oxidative stress, suggesting that 5-HTR can be used as a potential target for treating DKD. In this review, therefore, we summarize the published information available for the involvement of 5-HT and 5-HTR antagonists in the pathogenesis of various diabetic complications with a particular focus of DKD. We conclude that 5-HTR is a potential therapeutic target for treating DKD, as it has been successfully applied in animal models and has currently being investigated in randomized and controlled clinical trials.

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