AbstractBackground. Many recent studies revealed that
the single nucleotide polymorphisms have considerable
effects on the susceptibility of cancer, such as prostate
cancer, lung cancer and gastric cancer. The E-cadherin, a
calcium-dependent transmembrane glycoprotein encoded
by CDH1 gene, is critical for epithelial construction, intercellular
adhesion and cell migration. Some associations
have been reported between single nucleotide polymorphisms
and gastric cancer in the Chinese population.
Objective. To investigate whether the single nucleotide
polymorphism in CDH1 gene is associated with the susceptibility
of gastric cancer in the Chinese population.
Material and methods. The genotypes of 5 known single
nucleotide polymorphisms (rs33935154, rs121964871,
rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls.
High resolution melting curve detection and sequencing
analysis were used in the present study. Results. There
is a statistical significance in the rs121964871 C>G polymorphism
between gastric cancer patients and healthy
controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals
(>50 years of age) carrying this risk factor may
be more susceptible to gastric cancer. Conclusions. The
results indicated that the rs121964871 C>G polymorphism
is associated with the susceptibility of gastric cancer in
the Chinese population, with some age and sex-dependent
tendencies observed.
Association Study of Single Nucleotide Polymorphisms in XRCC1 Gene with the Risk of Gastric Cancer in Chinese Population
