CyclinD1 Single Nucleotide Polymorphisms and Risk of Gastric Cancer among Iranian Patients. A Pilot Genetic Association Study

Gastric cancer is one of the leading worldwide cancers formed in the lining of the stomach, and is the most prevalent cancer in northern Iran. Recent interventions for the early diagnosis of gastric cancer are based on genetic susceptibility parameters and the interactions between genes and the environment. Accordingly, this narrative review was designed to summarize the genetic markers involved in Iranian patients with gastric cancer, classified by cellular function. There was a significant relationship between single nucleotide polymorphisms (SNPs) in rs1051208 C allele (RAF1), rs531564 (pri-miR-124-1), rs1053023 (STAT3), rs8193 C allele (CD44), rs3130932G allele (OCT4), rs283821943, rs2032586 (ABCB1), codons 72,248 (p53), -137 G/C (IL-18), Pro12Ala (PPARγ), rs1053023 (STAT3), rs4647603 (caspase 3), -712C>T (caspase 9), -1263 A> (caspase 9) and gastric cancer. Increased risk was observed in C677T (MTHFR). Finally, decreased risk of gastric cancer was explored in -938 C>A (bcl2). Asp299Gly (TLR-4), rs1028181-513T/C (IL-19) Pro12Ala (PPARγ) may play a crucial role in susceptibility of Helicobacter pylori and gastric pathogenesis. According to the findings, the genetic polymorphisms in the immune-associated genes were related to the gastric cancer among the Iranian patients. Therefore, further large-scale functional investigations are needed to draw definite conclusions.

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Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population

Medical Oncology ◽

10.1007/s12032-014-0401-1 ◽

2014 ◽

Vol 32 (1) ◽

Cited By ~ 10

Author(s):

Guo-cong Wu ◽

Zhong-tao Zhang

Keyword(s):

Gastric Cancer ◽

Cancer Risk ◽

Single Nucleotide Polymorphisms ◽

Genetic Association ◽

Chinese Han Population ◽

Nucleotide Polymorphisms ◽

Gastric Cancer Risk ◽

Chinese Han ◽

Single Nucleotide ◽

Han Population

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Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

PLoS ONE ◽

10.1371/journal.pone.0251090 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0251090

Author(s):

Guangzhi Yang ◽

Boshen Wang ◽

Dawei Sun ◽

Huimin Wang ◽

Mengyao Chen ◽

...

Keyword(s):

Hearing Loss ◽

Association Study ◽

Genetic Association ◽

Genetic Association Study ◽

Control Group ◽

Case Group ◽

Noise Induced Hearing Loss ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Healthy Control

Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.

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