scholarly journals Simultaneous Inhibition of Cell-Cycle, Proliferation, Survival, Metastatic Pathways and Induction of Apoptosis in Breast Cancer Cells by a Phytochemical Super-Cocktail: Genes That Underpin Its Mode of Action

2013 ◽  
Vol 4 (9) ◽  
pp. 703-715 ◽  
Author(s):  
Allal Ouhtit ◽  
Rajiv Lochan Gaur ◽  
Mohamed Abdraboh ◽  
Shubha K. Ireland ◽  
Prakash N Rao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Mode Of Action ◽  
Breast Cancer Cells ◽  
Simultaneous Inhibition ◽  
Induction Of Apoptosis

scholarly journals Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56982 ◽  
Author(s):  
Sreevidya Santha ◽  
Ajay Bommareddy ◽  
Brittny Rule ◽  
Ruth Guillermo ◽  
Radhey S. Kaushik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cycle Arrest ◽  
M Phase ◽  
Estrogen Receptor Positive ◽  
Induction Of Apoptosis ◽  
Estrogen Receptor Negative

scholarly journals Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nursyamirah Abd Razak ◽  
Nadiah Abu ◽  
Wan Yong Ho ◽  
Nur Rizi Zamberi ◽  
Sheau Wei Tan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cycle Arrest ◽  
Induction Of Apoptosis ◽  
Mcf 7

Cell cycle arrest and induction of apoptosis by cajanin stilbene acid from Cajanus cajan in breast cancer cells

Phytomedicine ◽  
2015 ◽  
Vol 22 (4) ◽  
pp. 462-468 ◽  
Author(s):  
Yujie Fu ◽  
Onat Kadioglu ◽  
Benjamin Wiench ◽  
Zuofu Wei ◽  
Chang Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Cajanus Cajan ◽  
Breast Cancer Cells ◽  
Cycle Arrest ◽  
Induction Of Apoptosis

In Vitro Assessment of Homeopathic Potencies of Hydrastis canadensis on Hormone-Dependent and Independent Breast Cancer

Homeopathy ◽  
2020 ◽  
Vol 109 (04) ◽  
pp. 198-206
Author(s):  
Sabiha Khan ◽  
Debadatta Nayak ◽  
Anil Khurana ◽  
Raj Kumar Manchanda ◽  
Chanderdeep Tandon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Caspase 3 ◽  
Hydrastis Canadensis ◽  
Induction Of Apoptosis ◽  
Mcf 7

Abstract Background Breast cancer is the second leading cause of cancer-related deaths in women. Conventional treatment such as chemotherapy, hormonal therapy and radiotherapy has decreased the mortality rate among cancer patients but has also revealed long-term side effects. Drug resistance and toxicity to normal cells compound the problems associated with the use of modern medicines. Hence, complementary or alternative treatment options are being explored. The current study, using different homeopathic potencies of Hydrastis canadensis, was conducted to distinguish between any effects they might have on hormone-dependent and independent breast cancer. Materials and Methods The cytotoxic effect of homeopathic medicine Hydrastis on hormone-dependent (MCF 7) and hormone-independent (MDA-MB-468) breast cancer cells was assessed using viability and colony-forming assays after 48 or 72 hours of treatment. Flow cytometry-based Annexin V-PI (propidium iodide), caspase 3 and cell cycle analysis was performed following treatment of cells with mother tincture or various potencies of Hydrastis (1C, 2C, 30C, 200C). Results Different potencies of Hydrastis displayed selective cytotoxic effects against MCF 7 cells, but only marginal effects against MDA-MB-468. The maximum cytotoxicity was established in the case of 1C following 72 hours of treatment. Treatment of breast cancer cells revealed an increase in the G0/G1 cell population, along with an increase in the caspase 3 levels and induction of apoptosis. Conclusion Hydrastis may have a selective cytotoxic effect against hormone-dependent breast cancer MCF 7 cells, leading to cell cycle arrest in the G0/G1 phase, which could be the plausible reason for the induction of apoptosis. The results need to be validated in vivo.

scholarly journals Inhibition of Cell Cycle and Induction of Apoptosis y Ethanol Leaves Extract of Chrysanthemum cinerariifolium (Trev.) In T47D Breast Cancer Cells

2020 ◽  
Vol 31 (1) ◽  
pp. 1
Author(s):  
Roihatul Mutiah ◽  
Alfiyah Laily Inayatin ◽  
Rahmi Annisa ◽  
Yen Yen Ari Indrawijaya ◽  
Anik Listiyana
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Induction Of Apoptosis

scholarly journals Cellular Effect of Curcumin and Citral Combination on Breast Cancer Cells: Induction of Apoptosis and Cell Cycle Arrest

2015 ◽  
Vol 18 (3) ◽  
pp. 225 ◽  
Author(s):  
Pinaki B. Patel ◽  
Vasudev R. Thakkar ◽  
Jagdish S. Patel
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cycle Arrest ◽  
Induction Of Apoptosis
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