scholarly journals Studies on the effects of 3-acetyl-4"-isovaleryltylosin against multiple-drug resistant strains of Staphylococcus aureus.

1981 ◽  
Vol 34 (3) ◽  
pp. 305-312 ◽  
Author(s):  
MASAMI TSUCHIYA ◽  
KAYOKO SUZUKAKE ◽  
MAKOTO HORI ◽  
TSUTOMU SAWA ◽  
TOMIO TAKEUCHI ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains

scholarly journals Antibacterial activity of combined medicinal plants extract against multiple drug resistant strains

2015 ◽  
Vol 5 ◽  
pp. S151-S154
Author(s):  
Rafiqul Islam ◽  
Md. Shahedur Rahman ◽  
Riad Hossain ◽  
Nazmun Nahar ◽  
Belal Hossin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Medicinal Plants ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Resistant Strains ◽  
Drug Resistant Strains ◽  
Plants Extract

Combinatorial Drug Therapy for Controlling Pseudomonas aeruginosa and Its Association With Chronic Condition of Diabetic Foot Ulcer

2019 ◽  
Vol 19 (1) ◽  
pp. 7-20 ◽  
Author(s):  
Prakhar Srivastava ◽  
Karthikeyan Sivashanmugam
Keyword(s):  
Diabetic Foot ◽  
Chronic Condition ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant ◽  
Pseudomonas Species ◽  
Resistant Strains ◽  
Drug Resistant Strains

Diabetic foot ulcer (DFU) is a major complication of diabetes mellitus, major observations of DFU cases have reported on amputation of foot region, and microbial bioburden during DFU is a major cause that affects healing of the wound regions. Pathogenic microbes are routinely isolated from these wound regions, especially Staphylococcus, Pseudomonas, Klebsiella, and Escherichia coli have been reported, whereas higher prevalence of Pseudomonas species during chronic condition in the deeper part of the wound, when left untreated, leads to gangrene. Multiple drug-resistant Pseudomonas strains are a new threat because of their biofilm-forming ability, making it more potent and incurable. Acyl homoserine lactones (AHL) are a group of signaling molecules that can regulate biofilm growth, and Las and Rhl operon generally work in tandem to initiate biofilm formation by Pseudomonas species. These signaling molecules also initiate virulence factors that correlates upregulation of inflammatory responses, and AHL can be a therapeutic target in order to prevent the efficacy of multiple drug-resistant strains that form biofilm and also can be an alternative solution against control of multiple drug-resistant strains.

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