scholarly journals Backward Bifurcation and the Endemic Equilibrium for an HIV/AIDS - Tuberculosis Co infection Model

2019 ◽  
Keyword(s):  
Backward Bifurcation ◽  
Endemic Equilibrium ◽  
Infection Model ◽  
Hiv Aids

Stability of a CD4+ T cell viral infection model with diffusion

2018 ◽  
Vol 11 (05) ◽  
pp. 1850071 ◽  
Author(s):  
Zhiting Xu ◽  
Youqing Xu
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Lyapunov Functions ◽  
Threshold Value ◽  
Endemic Equilibrium ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
Viral Infection Model

This paper is devoted to the study of the stability of a CD[Formula: see text] T cell viral infection model with diffusion. First, we discuss the well-posedness of the model and the existence of endemic equilibrium. Second, by analyzing the roots of the characteristic equation, we establish the local stability of the virus-free equilibrium. Furthermore, by constructing suitable Lyapunov functions, we show that the virus-free equilibrium is globally asymptotically stable if the threshold value [Formula: see text]; the endemic equilibrium is globally asymptotically stable if [Formula: see text] and [Formula: see text]. Finally, we give an application and numerical simulations to illustrate the main results.

scholarly journals Mathematical analysis of HIV/AIDS infection model with Caputo-Fabrizio fractional derivative

2018 ◽  
Vol 5 (1) ◽  
pp. 1432521 ◽  
Author(s):  
Samia Bushnaq ◽  
Sajjad Ali Khan ◽  
Kamal Shah ◽  
Gul Zaman ◽  
Fawang Liu
Keyword(s):  
Fractional Derivative ◽  
Mathematical Analysis ◽  
Infection Model ◽  
Hiv Aids

scholarly journals Analysis of HIV Transmission of Commercial Sex Wokers and Their Clients with Condom Use Treatment

2019 ◽  
Vol 125 ◽  
pp. 05003 ◽  
Author(s):  
Sutimin ◽  
Siti Khabibah ◽  
Dita Anies Munawwaroh ◽  
R. Heri Soelistyo U
Keyword(s):  
Condom Use ◽  
Global Stability ◽  
Sex Workers ◽  
Hiv Transmission ◽  
Equilibrium States ◽  
Endemic Equilibrium ◽  
Reproduction Ratio ◽  
Aids Epidemic ◽  
The Impact ◽  
Hiv Aids

A model of the HIV/AIDS epidemic among sex workers and their clients is discussed to study the effects of condom use in the prevention of HIV transmission. The model is addressed to determine the existence of equilibrium states, and then analyze the global stability of disease free and endemic equilibrium states. The global stability of equilibria depends on the vales of the basic reproduction ratio derived from the next generation matrix of the model. The endemic equilibrium state is globally stable when the ratio exceeds unity. The simulation results are presented to discuss the effect of condom use treatment in preventing the spread of HIV/AIDS among sex workers and their clients. The results show that the effectiveness level in using condoms in sexual intercourse corresponds to the decreasing level of the spread of HIV/AIDS. We use Maple and Matlab software to simulate the impact of condom use.

scholarly journals Optimal Control and Cost-effectiveness Analysis of an HPV-Chlamydia Trachomatis co-infection model

2020 ◽  
Author(s):  
Andrew Omame ◽  
Celestine Uchenna Nnanna ◽  
Simeon Chioma Inyama
Keyword(s):  
Optimal Control ◽  
Cost Effectiveness ◽  
Chlamydia Trachomatis ◽  
Reproduction Number ◽  
Population Level ◽  
Backward Bifurcation ◽  
Infection Model ◽  
Control Analysis ◽  
Number Of Individuals ◽  
Positive Population

In this work, a co-infection model for human papillomavirus (HPV) and Chlamydia trachomatis with cost-effectiveness optimal control analysis is developed and analyzed. The disease-free equilibrium of the co-infection model is \textbf{shown not to} be globally asymptotically stable, when the associated reproduction number is less unity. It is proven that the model undergoes the phenomenon of backward bifurcation when the associated reproduction number is less than unity. It is also shown that HPV re-infection ($\varepsilon\sst{p} \neq 0$) induced the phenomenon of backward bifurcation. Numerical simulations of the optimal control model showed that: (i) focusing on HPV intervention strategy alone (HPV prevention and screening), in the absence of Chlamydia trachomatis control, leads to a positive population level impact on the total number of individuals singly infected with Chlamydia trachomatis, (ii) Concentrating on Chlamydia trachomatis intervention controls alone (Chlamydia trachomatis prevention and treatment), in the absence of HPV intervention strategies, a positive population level impact is observed on the total number of individuals singly infected with HPV. Moreover, the strategy that combines and implements HPV and Chlamydia trachomatis prevention controls is the most cost-effective of all the control strategies in combating the co-infections of HPV and Chlamydia trachomatis.

scholarly journals MODELLING THE TRANSMISSION DYNAMICS OF CONTAGIOUS BOVINE PLEUROPNEUMONIA IN THE PRESENCE OF ANTIBIOTIC TREATMENT WITH LIMITED MEDICAL SUPPLY

2021 ◽  
Vol 26 (1) ◽  
pp. 1-20
Author(s):  
Achamyelesh A. Aligaz ◽  
Justin M. W. Munganga
Keyword(s):  
Antibiotic Treatment ◽  
Backward Bifurcation ◽  
Endemic Equilibrium ◽  
Transmission Dynamics ◽  
Asymptotically Stable ◽  
Contagious Bovine Pleuropneumonia ◽  
Globally Asymptotically Stable ◽  
Medical Supply ◽  
Delayed Treatment ◽  
Disease Free

We present and analyze a mathematical model of the transmission dynamics of Contagious Bovine Pleuropneumonia (CBPP) in the presence of antibiotic treatment with limited medical supply. We use a saturated treatment function to model the effect of delayed treatment. We prove that there exist one disease free equilibrium and at most two endemic equilibrium solutions. A backward bifurcation occurs for small values of delay constant such that two endemic equilibriums exist if Rt (R*t,1); where, Rt is the treatment reproduction number and R*t is a threshold such that the disease dies out if and persists in the population if Rt > R*t. However, when a backward bifurcation occurs, a disease free system may easily be shifted to an epidemic. The bifurcation turns forward when the delay constant increases; thus, the disease free equilibrium becomes globally asymptotically stable if Rt < 1, and there exist unique and globally asymptotically stable endemic equilibrium if Rt > 1. However, the amount of maximal medical resource required to control the disease increases as the value of the delay constant increases. Thus, antibiotic treatment with limited medical supply setting would not successfully control CBPP unless we avoid any delayed treatment, improve the efficacy and availability of medical resources or it is given along with vaccination.

scholarly journals A co-infection model for Two-Strain Malaria and Cholera with Optimal Control

2020 ◽  
Author(s):  
Kenneth Uzoma Egeonu ◽  
Simeon Chioma Inyama ◽  
Andrew Omame
Keyword(s):  
Optimal Control ◽  
Drug Resistance ◽  
Necessary Conditions ◽  
Reproduction Number ◽  
Dynamical Property ◽  
Backward Bifurcation ◽  
Infection Model ◽  
Existence Of Optimal Control ◽  
The Impact ◽  
Disease Free

A mathematical model for two strains of Malaria and Cholera with optimal control is studied and analyzed to assess the impact of treatment controls in reducing the burden of the diseases in a population, in the presence of malaria drug resistance. The model is shown to exhibit the dynamical property of backward bifurcation when the associated reproduction number is less than unity. The global asymptotic stability of the disease-free equilibrium of the model is proven not to exist. The necessary conditions for the existence of optimal control and the optimality system for the model is established using the Pontryagin's Maximum Principle. Numerical simulations of the optimal control model reveal that malaria drug resistance can greatly influence the co-infection cases averted, even in the presence of treatment controls for co-infected individuals.

Analysis of a mathematical model for the transmission dynamics of human melioidosis

2020 ◽  
Vol 13 (07) ◽  
pp. 2050062
Author(s):  
Yibeltal Adane Terefe ◽  
Semu Mitiku Kassa
Keyword(s):  
Human Population ◽  
Deterministic Model ◽  
Reproduction Number ◽  
Backward Bifurcation ◽  
Endemic Equilibrium ◽  
Transmission Dynamics ◽  
Asymptotically Stable ◽  
Disease Dynamics ◽  
Number Formula ◽  
Disease Free

A deterministic model for the transmission dynamics of melioidosis disease in human population is designed and analyzed. The model is shown to exhibit the phenomenon of backward bifurcation, where a stable disease-free equilibrium co-exists with a stable endemic equilibrium when the basic reproduction number [Formula: see text] is less than one. It is further shown that the backward bifurcation dynamics is caused by the reinfection of individuals who recovered from the disease and relapse. The existence of backward bifurcation implies that bringing down [Formula: see text] to less than unity is not enough for disease eradication. In the absence of backward bifurcation, the global asymptotic stability of the disease-free equilibrium is shown whenever [Formula: see text]. For [Formula: see text], the existence of at least one locally asymptotically stable endemic equilibrium is shown. Sensitivity analysis of the model, using the parameters relevant to the transmission dynamics of the melioidosis disease, is discussed. Numerical experiments are presented to support the theoretical analysis of the model. In the numerical experimentations, it has been observed that screening and treating individuals in the exposed class has a significant impact on the disease dynamics.

scholarly journals Analisis Kestabilan Model Host-Vector Transmisi HIV/AIDS Pada Pengguna Jarum Suntik

2017 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Jafaruddin (Alm) ◽  
Rapmaida M. Pangaribuan ◽  
. Aryanto ◽  
Irena A. Henukh
Keyword(s):  
Sensitivity Analysis ◽  
Equilibrium Point ◽  
Drug Users ◽  
Endemic Equilibrium ◽  
Vector Model ◽  
Stability Conditions ◽  
Keywords Hiv ◽  
The Stability ◽  
Disease Free ◽  
Hiv Aids

HIV/AIDS is a very dangerous disease. The transmission of  HIV/AIDS can be in three ways  and one of them through a syringe. In this paper we describe SIR and SEIR Host-Vector  model transmission of HIV/AIDS amongst populations of  injecting drug users. From the existing model we obtained disease-free equilibrium  point and endemic equilibrium point. Then we study the stability conditions and sensitivity analysis of the  . The analysis shows if   then the disease-free equilibrium  point is stable and if    then the endemic equilibrium point will be stable. We also obtained that parameter of probality host-vector infected with HIV/AIDS affects the increase of  number  infected HIV/AIDS. Keywords: HIV/AIDS, Host-Vector Transmission, The Stability of Equilibrium Point.

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