scholarly journals Skin Nodules as a First Presentation of Synchronous Bilateral Invasive Lobular Breast Carcinoma: A Case Report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sara Khodair ◽  
Iman Ewais ◽  
Hanaa Abolmagd ◽  
Rehab El Sheikh ◽  
Sughra Raza ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Type Ii Diabetes ◽  
Lobular Carcinoma ◽  
Skin Lesions ◽  
Adult Women ◽  
Breast Lump ◽  
Skin Metastases ◽  
History Of ◽  
Skin Nodules ◽  
Lobular Breast Carcinoma

The most common cause of skin metastases in adult women is primary breast carcinoma, which comprises about 70% of cases [1]. Skin metastases have non-specific clinical appearances, making it challenging to differentiate them from other benign conditions [1]. We present a case of a 52-year-old female with type II diabetes and a three-month history of refractory skin lesions who did not respond to anti-inflammatory treatment. The patient subsequently complained of a right breast lump, evaluation of which led to the diagnosis of bilateral synchronous invasive lobular carcinoma.

scholarly journals Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2090720
Author(s):  
Mariangela Gomez ◽  
Kerry Whitting ◽  
Rana Naous
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Tamoxifen Therapy ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Post Menopausal ◽  
Rule Out

Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly from the ovaries. Among non-gynecologic origins, breast tumors are the most frequent primaries, predominantly the lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with lobular breast carcinoma 5 years ago, status post modified radical mastectomy, and currently on tamoxifen therapy presented with post-menopausal bleeding. Subsequent endometrial biopsy confirmed the diagnosis of metastatic lobular breast carcinoma to the endometrium. Breast carcinomas rarely metastasize to the uterus, especially lobular carcinoma type. Abnormal uterine bleeding in a patient with known history of breast carcinoma and under tamoxifen therapy should prompt a complete diagnostic workup to rule out metastatic disease.

scholarly journals Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Rodolfo Franco-Márquez ◽  
Adrián Gerardo Torres-Gaytán ◽  
Marcela Anahí Narro-Martinez ◽  
Anahí Carrasco-Chapa ◽  
Benjamín Gómez Núñez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Review Of Literature ◽  
Lobular Breast Carcinoma

There are few reports of breast cancer cases with uterine metastases. Here, we report a metastatic lobular carcinoma to endometrium presenting as abnormal uterine bleeding. Diagnosis was based in previous lobular breast carcinoma and immunohistochemistry.

scholarly journals Duodenal metastasis of breast invasive carcinoma of no special type: a rare presentation

2021 ◽  
Vol 84 (2) ◽  
pp. 379-380
Author(s):  
M Mascarenhas Saraiva ◽  
T Ribeiro ◽  
A.R. Coelho ◽  
R Silva ◽  
A.C. Real ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Epigastric Pain ◽  
Growth Factor Receptor ◽  
Progesterone Receptors ◽  
Ca 125 ◽  
Her2 Positive ◽  
Rare Presentation ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Epidermal Growth

The authors read with attention the case report by Vande Berg and coworkers, published on a previous issue of this journal, describing a rare diagnosis of rectal metastases of an incognito invasive lobular breast carcinoma (ILC), for which immunohistochemistry was decisive (1). Likewise, we share a similarly rare case of gastrointestinal metastases of breast carcinoma (BC), in which immunohistochemistry played a pivotal role.A 55-year-old woman was diagnosed in June 2015 with an Invasive Breast Carcinoma of no-special-type (IBCNST) grade III, human epidermal growth factor receptor 2 (HER2) positive, estrogen and progesterone receptors (ER/PR) negative. Biopsy revealed vascular permeation. Neoadjuvant chemotherapy and trastuzumab preceded surgery, performed in December 2015, followed by radiotherapy and trastuzumab. The patient remained free of disease until 2017, when a right cerebellar lesion was diagnosed as BC metastasis and was treated with stereotactic radiosurgery. In January 2020, the patient presented with a 1-month history of post-prandial vomiting, epigastric pain, anorexia, fatigue, and a 10 kg weight loss. Lab tests were unremarkable, except for small increase in CA-125 and CA-15.3.

scholarly journals Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Gabriel M. Groisman
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Accessory Spleen ◽  
Extramedullary Hematopoiesis ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
Splenic Parenchyma ◽  
Lobular Breast Carcinoma ◽  
Accessory Spleens

Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.

scholarly journals Gastric metastases from primary breast cancers: rare causes of common gastrointestinal disorders

2020 ◽  
Vol 13 (7) ◽  
pp. e231763
Author(s):  
Tiffany Yuen ◽  
Eddie Liu ◽  
Ali Kohansal
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Breast Tumour ◽  
Breast Cancers ◽  
Endoscopic Appearance ◽  
Cancer History ◽  
Early Satiety ◽  
Gi Symptoms ◽  
History Of ◽  
Gastric Metastases

We report two cases of gastric metastases from primary breast cancers. In case 1, a 31-year-old woman with right-sided ductal breast carcinoma presented with nausea, vomiting and frank haematemesis, 8 months after mastectomy and adjuvant chemotherapy. An esophagogastroduodenoscopy (EGD) revealed multiple ulcerated gastric lesions secondary to metastatic adenocarcinoma from primary breast tumour. In case 2, an 84-year-old woman with a history of left lobular carcinoma presented with early satiety, 17 years after initial mastectomy and adjuvant endocrine therapy. An EGD revealed unspecific gastric mucosa with thickened and erythematous folds and biopsies revealed adenocarcinoma from primary breast carcinoma. Our cases demonstrate how gastric metastases have variable, non-specific clinical and endoscopic presentations. Symptoms may include nausea, vomiting, early satiety and gastrointestinal (GI) bleeding. Endoscopic appearance may range from thickened gastric folds to ulcerating lesions. Our cases demonstrate that gastric metastases should be considered in patients with breast cancer history presenting with GI symptoms.

Gastric Metastasis 14 Years after Mastectomy for Breast Lobular Carcinoma: Case Report and Literature Review

2006 ◽  
Vol 72 (5) ◽  
pp. 456-460 ◽  
Author(s):  
Paolo Aurello ◽  
Francesco D'Angelo ◽  
Giulia Cosenza ◽  
Sergio Petrocca ◽  
Antonella Stoppacciaro ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Subtotal Gastrectomy ◽  
Immunohistochemical Analysis ◽  
Gastric Neoplasm ◽  
Surgical Specimen ◽  
Symptomatic Disease ◽  
Lobular Breast Carcinoma ◽  
Previously Treated ◽  
Rule Out

In planning treatment of a gastric neoplasm in a patient previously treated for lobular breast carcinoma, it is important to differentiate a primary gastrointestinal tract tumor from a metastatic form. We report a case of a breast lobular carcinoma metastatic to the stomach. The patient underwent a subtotal gastrectomy for symptomatic disease. Although gastric symptoms appeared 14 years after the breast carcinoma, immunohistochemical analysis of the surgical specimen helped to establish that the gastric lesion, thought to be primary, was effectively a metastatic repetition of the breast neoplasm. To better define treatment in a gastric neoplasm patient previously treated for breast carcinoma, the preoperative diagnosis should rule out a metastatic disease. The patient described received an adjuvant chemotherapy according to breast cancer protocol after gastric resection for symptomatic disease. The patient is still alive and undergoing chemotherapy for peritoneal carcinosis.

scholarly journals Diarrhoea Caused by Diffuse Metastatic Lobular Breast Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Sjoerd F. Bakker ◽  
Willem Moolenaar ◽  
Marije M. van Santen ◽  
Mathijs P. Hendriks
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Gastrointestinal Symptoms ◽  
Laboratory Research ◽  
Ascending Colon ◽  
Lobular Breast Cancer ◽  
The Past ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Descending Colon

A 70-year-old woman with a history of lobular breast cancer presented to our Outpatient Clinic with diarrhoea for the past 3 years. Clinical examination and laboratory research were normal. Colonoscopy showed diffuse mild erythema and a decreased vascular pattern. Biopsies from the ascending colon, transverse colon, and descending colon showed metastases of lobular breast carcinoma. Although gastrointestinal metastases are rare in breast cancer, our case emphasizes the need for further diagnostic efforts in patients with gastrointestinal symptoms and a history of breast carcinoma.

Metastases from lobular breast cancer as an unusual source of GI bleeding.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Emily Clarke ◽  
James George ◽  
Andrew Peter Dean
Keyword(s):  
Breast Cancer ◽  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Gi Bleeding ◽  
Lobular Breast Cancer ◽  
Gi Tract ◽  
Invasive Ductal Breast Carcinoma ◽  
Lobular Breast Carcinoma

e12557 Background: With the exception of malignant melanoma, metastases to the GI tract are rare, especially as a first presentation of malignancy. We report a series of patients with GI metastases from lobular breast carcinoma as an unusual source of symptomatic GI bleeding. Methods: We conducted an electronic database search to identify solid tumour patients (excluding melanoma) with metastases to the GI tract. We then analysed the database by tumour type. Results: 3 cases of proven metastasis to the GI tract were identified. All had lobular breast cancer metastases. The database contained 240 patients with breast cancer, identifying 63 with infiltrating lobular carcinoma, 2 with micropapillary and 175 with invasive ductal carcinoma The 1st case had had invasive ductal breast carcinoma 6 years previously and presented with fatigue and shortness of breath from anaemia. Colonoscopy revealed a polyp which was removed. Histopathology showed metastatic lobular breast carcinoma. Further investigation then confirmed an occult breast mass with identical pathology. The 2nd case presented with 18 months of abdominal pain, previous colonoscopy was normal. After onset of anaemia and 25kg weight loss, upper GI endoscopy showed a markedly thickened stomach with evidence of recent bleeding and biopsies confirmed metastatic lobular breast carcinoma. The 3rd case presented with abdominal pain, subsequent blood tests showing a raised CA125 with omental and ovarian masses. Surgical debulking showed metastatic lobular breast carcinoma, though no primary breast lesion was detectable with mammography, ultrasound and MRI. 3 years later, investigation of anaemia with colonoscopy showed a caecal polyp with histology confirming lobular breast carcinoma. Conclusions: Despite all common tumour types being represented in the database it is notable that all 3 cases with mucosal GI metastases had lobular breast cancer. Previous evidence suggests a long latent period from initial diagnosis of breast cancer to development of GI metastases however our report suggests it can occur earlier in the illness. Clinicians should consider this as a rare cause of GI bleeding and further research to understand the mechanism of mucosal metastasis in lobular breast cancer is needed.

Ultrasonography of invasive lobular breast carcinoma

1998 ◽  
Vol 39 (3) ◽  
pp. 285-291 ◽  
Author(s):  
T. Rissanen ◽  
T. Tikkakoski ◽  
A.-L. Autio ◽  
M. Apaja-Sarkkinen
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Architectural Distortion ◽  
Dense Breasts ◽  
The Us ◽  
Lobular Breast Carcinoma ◽  
Us Findings ◽  
Acoustic Shadowing

Purpose: To review the US findings in invasive lobular breast carcinoma which is often difficult to diagnose clinically and mammographically Material and Methods: The mammographic and US findings in 63 cases of pure invasive lobular carcinoma diagnosed at our institution in 1990-1996 were reviewed retrospectively. The US findings were classified as positive, negative or indeterminate for malignancy Results: Forty-nine of the 63 lobular carcinomas (78%, 95% CI 65.5-87.3%) were US-positive, and 51 (81%, CI 95% 69.1-89.8%) were mammography-positive. The US visibility of the carcinomas was affected by their palpability and mammographic appearance, and the radiographic density of the breasts. Indeterminate US findings (architectural distortion with acoustic shadowing) were visualized in 4 of the 10 cases that had asymmetric densities at mammography Conclusion: The sensitivity of US for lobular carcinoma was not statistically different from that of mammography. The methods were complementary, especially with regard to evaluating dense breasts and lesions which were difficult to assess clinically and mammographically

Colon metastases as first clinical manifestation of lobular breast carcinoma with no subsequent evidence of breast disease

2020 ◽  
Vol 13 (11) ◽  
pp. e236225
Author(s):  
Mohammed Isaac Abu Zaanona ◽  
Aishwarya Gulati ◽  
Kendrith Rowland
Keyword(s):  
Breast Carcinoma ◽  
Colonic Mucosa ◽  
Altered Mental Status ◽  
Breast Disease ◽  
Watery Diarrhoea ◽  
Wall Thickening ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Bowel Wall Thickening ◽  
Vague Abdominal Pain

A 73-year-old woman was brought to the oestrogen receptor for altered mental status. She was found to be hypotensive and hypoglycaemic and admitted to the intensive care unit. She had a history of chronic watery diarrhoea which had recently increased over the last 2 weeks and was associated with vague abdominal pain. A CT showed bowel wall thickening concerning for colitis. Due to the increasing diarrhoea, a colonoscopy was done after all stool studies came back negative. Polyps in the ascending, transverse and sigmoid colon were found to be tubular adenomas but random colonic mucosa biopsies were revealed to be histologically consistent with metastatic lobular breast carcinoma. Further workup revealed no primary breast disease.

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