Ultrasonography of invasive lobular breast carcinoma

1998 ◽  
Vol 39 (3) ◽  
pp. 285-291 ◽  
Author(s):  
T. Rissanen ◽  
T. Tikkakoski ◽  
A.-L. Autio ◽  
M. Apaja-Sarkkinen
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Architectural Distortion ◽  
Dense Breasts ◽  
The Us ◽  
Lobular Breast Carcinoma ◽  
Us Findings ◽  
Acoustic Shadowing

Purpose: To review the US findings in invasive lobular breast carcinoma which is often difficult to diagnose clinically and mammographically Material and Methods: The mammographic and US findings in 63 cases of pure invasive lobular carcinoma diagnosed at our institution in 1990-1996 were reviewed retrospectively. The US findings were classified as positive, negative or indeterminate for malignancy Results: Forty-nine of the 63 lobular carcinomas (78%, 95% CI 65.5-87.3%) were US-positive, and 51 (81%, CI 95% 69.1-89.8%) were mammography-positive. The US visibility of the carcinomas was affected by their palpability and mammographic appearance, and the radiographic density of the breasts. Indeterminate US findings (architectural distortion with acoustic shadowing) were visualized in 4 of the 10 cases that had asymmetric densities at mammography Conclusion: The sensitivity of US for lobular carcinoma was not statistically different from that of mammography. The methods were complementary, especially with regard to evaluating dense breasts and lesions which were difficult to assess clinically and mammographically

scholarly journals Molecular breast imaging detected invasive lobular carcinoma in dense breasts: A case report

2019 ◽  
Vol 7 (3) ◽  
pp. 442-444 ◽  
Author(s):  
Naziya Samreen ◽  
Katie N. Hunt ◽  
Carrie B. Hruska ◽  
Deborah J. Rhodes
Keyword(s):  
Case Report ◽  
Invasive Lobular Carcinoma ◽  
Breast Imaging ◽  
Lobular Carcinoma ◽  
Molecular Breast Imaging ◽  
Dense Breasts

scholarly journals Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2090720
Author(s):  
Mariangela Gomez ◽  
Kerry Whitting ◽  
Rana Naous
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Tamoxifen Therapy ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Post Menopausal ◽  
Rule Out

Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly from the ovaries. Among non-gynecologic origins, breast tumors are the most frequent primaries, predominantly the lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with lobular breast carcinoma 5 years ago, status post modified radical mastectomy, and currently on tamoxifen therapy presented with post-menopausal bleeding. Subsequent endometrial biopsy confirmed the diagnosis of metastatic lobular breast carcinoma to the endometrium. Breast carcinomas rarely metastasize to the uterus, especially lobular carcinoma type. Abnormal uterine bleeding in a patient with known history of breast carcinoma and under tamoxifen therapy should prompt a complete diagnostic workup to rule out metastatic disease.

Correlations Between Ultrasonographic Findings of Invasive Lobular Carcinoma of the Breast and Intrinsic Subtypes

2018 ◽  
Vol 40 (06) ◽  
pp. 764-770
Author(s):  
Xin Wen ◽  
Yingjiao Yu ◽  
Xiwen Yu ◽  
Wen Cheng ◽  
Zhuozhong Wang ◽  
...  
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Breast Imaging ◽  
Lobular Carcinoma ◽  
Her2 Overexpression ◽  
Intrinsic Subtypes ◽  
Luminal A ◽  
Luminal B ◽  
The Masses ◽  
Accurate Imaging ◽  
Acoustic Shadowing

Abstract Purpose To analyze the ultrasonographic findings of invasive lobular carcinoma (ILC) of the breast in 360 women and the correlations between the characteristics and the intrinsic subtypes. Materials and Methods We evaluated the imaging findings according to the lexicon of the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS). The included ultrasonographic features were shape, orientation, margin, echo pattern, posterior features, calcifications, the vascularity of the masses and the presence of architectural distortions. The associations between those features and the intrinsic ILC subtypes were investigated. Results The most common manifestations of ILC on ultrasound (US) were hypoechoic masses with irregular shape, parallel orientation, spiculated margin, posterior acoustic shadowing, no calcification and blood vessels in the rim. The patients in the luminal A subtype were the youngest, and the patients in the HER2 overexpression subtype were the oldest (p = 0.01). On US, the HER2 overexpression subtype was characterized by microlobulated margins (p = 0.002), while the luminal A subtype and the luminal B subtype mostly had spiculated margins. The basal-like subtype was distinctive in that it had no posterior features (p = 0.041), rather than acoustic shadowing, and the masses in the HER2 and basal-like subtypes were larger than in the other two groups (p = 0.03). Conclusion There were significant differences and several trends in the ultrasonographic characteristics of different intrinsic subtypes, which may supply accurate imaging diagnostic criteria to assist in the management of individuals with ILC.

scholarly journals Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Rodolfo Franco-Márquez ◽  
Adrián Gerardo Torres-Gaytán ◽  
Marcela Anahí Narro-Martinez ◽  
Anahí Carrasco-Chapa ◽  
Benjamín Gómez Núñez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Review Of Literature ◽  
Lobular Breast Carcinoma

There are few reports of breast cancer cases with uterine metastases. Here, we report a metastatic lobular carcinoma to endometrium presenting as abnormal uterine bleeding. Diagnosis was based in previous lobular breast carcinoma and immunohistochemistry.

scholarly journals Lobular Breast Cancer: A Review

2021 ◽  
Vol 10 ◽  
Author(s):  
Natalie Wilson ◽  
Alastair Ironside ◽  
Anna Diana ◽  
Olga Oikonomidou
Keyword(s):  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Management Strategies ◽  
Incidence Rates ◽  
Breast Cancers ◽  
Current Standard ◽  
The Past ◽  
Molecular Features ◽  
Estrogen Receptor Positivity ◽  
Lobular Breast Carcinoma

Invasive lobular carcinoma accounts for 5%–15% of all invasive breast cancers, with a marked increase in incidence rates over the past two decades. Distinctive biological hallmarks of invasive lobular carcinoma include the loss of cell adhesion molecule E-cadherin leading to cells with a discohesive morphology, proliferating into single-file strands and estrogen receptor positivity. These key molecular features can make diagnosis difficult, as invasive lobular carcinoma is challenging to detect both physically and with current standard imaging. Treatment of invasive lobular carcinoma strongly favors endocrine therapy due to low chemosensitivity and lower rates of pathological response as a result. This review will summarize the distinct biological and molecular features of invasive lobular carcinoma, focusing on the diagnostic challenges faced and the subsequent surgical and medical management strategies. Prospective therapeutic options will also be explored, highlighting how furthering our understanding of the unique biology of lobular breast carcinoma is essential in guiding and informing the treatment of patients in the future.

scholarly journals Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Gabriel M. Groisman
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Accessory Spleen ◽  
Extramedullary Hematopoiesis ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
Splenic Parenchyma ◽  
Lobular Breast Carcinoma ◽  
Accessory Spleens

Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.

Gastric Metastasis 14 Years after Mastectomy for Breast Lobular Carcinoma: Case Report and Literature Review

2006 ◽  
Vol 72 (5) ◽  
pp. 456-460 ◽  
Author(s):  
Paolo Aurello ◽  
Francesco D'Angelo ◽  
Giulia Cosenza ◽  
Sergio Petrocca ◽  
Antonella Stoppacciaro ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Subtotal Gastrectomy ◽  
Immunohistochemical Analysis ◽  
Gastric Neoplasm ◽  
Surgical Specimen ◽  
Symptomatic Disease ◽  
Lobular Breast Carcinoma ◽  
Previously Treated ◽  
Rule Out

In planning treatment of a gastric neoplasm in a patient previously treated for lobular breast carcinoma, it is important to differentiate a primary gastrointestinal tract tumor from a metastatic form. We report a case of a breast lobular carcinoma metastatic to the stomach. The patient underwent a subtotal gastrectomy for symptomatic disease. Although gastric symptoms appeared 14 years after the breast carcinoma, immunohistochemical analysis of the surgical specimen helped to establish that the gastric lesion, thought to be primary, was effectively a metastatic repetition of the breast neoplasm. To better define treatment in a gastric neoplasm patient previously treated for breast carcinoma, the preoperative diagnosis should rule out a metastatic disease. The patient described received an adjuvant chemotherapy according to breast cancer protocol after gastric resection for symptomatic disease. The patient is still alive and undergoing chemotherapy for peritoneal carcinosis.

scholarly journals Sonographic Findings of Additional Malignant Lesions in Breast Carcinoma Seen by Second Look Ultrasound

2011 ◽  
Vol 1 ◽  
pp. 34 ◽  
Author(s):  
Ana Delgado Laguna ◽  
S Jimenez Arranz ◽  
V Quintana Checa ◽  
S Alonso Roca ◽  
D Expósito Jiménez ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Primary Lesion ◽  
Resonance Imaging ◽  
Double Blind ◽  
Additional Lesion ◽  
Second Look ◽  
The Us ◽  
Malignant Lesions ◽  
Magnetic Resonance Imaging Mri ◽  
Us Findings

Objective: The aim is to show ultrasound (US) findings of additional malignant lesions of breast carcinoma visualized on targeted second-look US that were not identified by mammography or US prior to the time of diagnosis. Materials and Methods: A double-blind retrospective review of the US results from January 2008 through August 2010 of 228 patients with known breast cancer was conducted by two expert radiologists. The focus of the review was on the second-look US characteristics (following BI-RADS criteria) of 26 documented additional malignant lesions of the 76 with successful sonographic correlation from the 123 lesions detected by magnetic resonance imaging (MRI). All of them, before the MRI, had an initial mammography and a US with a histopathological biopsy of the primary lesion. Results: Approximately 60 to 70% of the findings were classified as BI-RADS 2 and BI-RADS 3, while assessing the final US category. The review of the second-look US showed the size of the second malignant additional lesion ranged from 3 to 22 mm, of which 90% were smaller than 10 mm and 66% were smaller than 7 mm. Conclusions: Most additional malignant lesions, nonpalpable carcinomas, which were previously not detected by mammography and US at first-look diagnosis, were detected by a targeted second-look US examination. These lesions were of category BI-RADS 2 and BI-RADS 3 and smaller than 7 mm.

scholarly journals Biliary Dyskinesia as a Rare Presentation of Metastatic Breast Carcinoma of the Gallbladder: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
A. Markelov ◽  
H. Taheri ◽  
K. Vunnamadala ◽  
G. Ibrahim
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Rare Presentation ◽  
Metastatic Breast Carcinoma ◽  
Carcinoma Metastasis ◽  
Invasive Lobular Breast Cancer ◽  
The Brain ◽  
Common Malignancy

Background. Breast carcinoma is the most common malignancy in women worldwide. It is most commonly associated with metastases to the liver, lung, bone, and the brain. Invasive lobular carcinoma is a less common pathology with slightly higher metastases to the upper gastrointestinal tract. Invasive lobular carcinoma metastasis to the gallbladder is extremely rare.Method. In this paper we are presenting a case of a 67-year-old female with metastases of invasive lobular breast cancer to the gallbladder six years after her therapy.Conclusion. This case clearly signifies the nature of the micrometastatic foci of the invasive lobular carcinoma even many years after a successful treatment.

Metastases from lobular breast cancer as an unusual source of GI bleeding.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Emily Clarke ◽  
James George ◽  
Andrew Peter Dean
Keyword(s):  
Breast Cancer ◽  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Gi Bleeding ◽  
Lobular Breast Cancer ◽  
Gi Tract ◽  
Invasive Ductal Breast Carcinoma ◽  
Lobular Breast Carcinoma

e12557 Background: With the exception of malignant melanoma, metastases to the GI tract are rare, especially as a first presentation of malignancy. We report a series of patients with GI metastases from lobular breast carcinoma as an unusual source of symptomatic GI bleeding. Methods: We conducted an electronic database search to identify solid tumour patients (excluding melanoma) with metastases to the GI tract. We then analysed the database by tumour type. Results: 3 cases of proven metastasis to the GI tract were identified. All had lobular breast cancer metastases. The database contained 240 patients with breast cancer, identifying 63 with infiltrating lobular carcinoma, 2 with micropapillary and 175 with invasive ductal carcinoma The 1st case had had invasive ductal breast carcinoma 6 years previously and presented with fatigue and shortness of breath from anaemia. Colonoscopy revealed a polyp which was removed. Histopathology showed metastatic lobular breast carcinoma. Further investigation then confirmed an occult breast mass with identical pathology. The 2nd case presented with 18 months of abdominal pain, previous colonoscopy was normal. After onset of anaemia and 25kg weight loss, upper GI endoscopy showed a markedly thickened stomach with evidence of recent bleeding and biopsies confirmed metastatic lobular breast carcinoma. The 3rd case presented with abdominal pain, subsequent blood tests showing a raised CA125 with omental and ovarian masses. Surgical debulking showed metastatic lobular breast carcinoma, though no primary breast lesion was detectable with mammography, ultrasound and MRI. 3 years later, investigation of anaemia with colonoscopy showed a caecal polyp with histology confirming lobular breast carcinoma. Conclusions: Despite all common tumour types being represented in the database it is notable that all 3 cases with mucosal GI metastases had lobular breast cancer. Previous evidence suggests a long latent period from initial diagnosis of breast cancer to development of GI metastases however our report suggests it can occur earlier in the illness. Clinicians should consider this as a rare cause of GI bleeding and further research to understand the mechanism of mucosal metastasis in lobular breast cancer is needed.

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