Gastric Metastasis 14 Years after Mastectomy for Breast Lobular Carcinoma: Case Report and Literature Review

2006 ◽  
Vol 72 (5) ◽  
pp. 456-460 ◽  
Author(s):  
Paolo Aurello ◽  
Francesco D'Angelo ◽  
Giulia Cosenza ◽  
Sergio Petrocca ◽  
Antonella Stoppacciaro ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Subtotal Gastrectomy ◽  
Immunohistochemical Analysis ◽  
Gastric Neoplasm ◽  
Surgical Specimen ◽  
Symptomatic Disease ◽  
Lobular Breast Carcinoma ◽  
Previously Treated ◽  
Rule Out

In planning treatment of a gastric neoplasm in a patient previously treated for lobular breast carcinoma, it is important to differentiate a primary gastrointestinal tract tumor from a metastatic form. We report a case of a breast lobular carcinoma metastatic to the stomach. The patient underwent a subtotal gastrectomy for symptomatic disease. Although gastric symptoms appeared 14 years after the breast carcinoma, immunohistochemical analysis of the surgical specimen helped to establish that the gastric lesion, thought to be primary, was effectively a metastatic repetition of the breast neoplasm. To better define treatment in a gastric neoplasm patient previously treated for breast carcinoma, the preoperative diagnosis should rule out a metastatic disease. The patient described received an adjuvant chemotherapy according to breast cancer protocol after gastric resection for symptomatic disease. The patient is still alive and undergoing chemotherapy for peritoneal carcinosis.

scholarly journals Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2090720
Author(s):  
Mariangela Gomez ◽  
Kerry Whitting ◽  
Rana Naous
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Radical Mastectomy ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Tamoxifen Therapy ◽  
History Of ◽  
Lobular Breast Carcinoma ◽  
Post Menopausal ◽  
Rule Out

Metastatic carcinomas to the uterus are rare and usually originate from nearby gynecologic sites, most commonly from the ovaries. Among non-gynecologic origins, breast tumors are the most frequent primaries, predominantly the lobular carcinoma type. A 69-year-old postmenopausal woman diagnosed with lobular breast carcinoma 5 years ago, status post modified radical mastectomy, and currently on tamoxifen therapy presented with post-menopausal bleeding. Subsequent endometrial biopsy confirmed the diagnosis of metastatic lobular breast carcinoma to the endometrium. Breast carcinomas rarely metastasize to the uterus, especially lobular carcinoma type. Abnormal uterine bleeding in a patient with known history of breast carcinoma and under tamoxifen therapy should prompt a complete diagnostic workup to rule out metastatic disease.

scholarly journals Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Rodolfo Franco-Márquez ◽  
Adrián Gerardo Torres-Gaytán ◽  
Marcela Anahí Narro-Martinez ◽  
Anahí Carrasco-Chapa ◽  
Benjamín Gómez Núñez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Review Of Literature ◽  
Lobular Breast Carcinoma

There are few reports of breast cancer cases with uterine metastases. Here, we report a metastatic lobular carcinoma to endometrium presenting as abnormal uterine bleeding. Diagnosis was based in previous lobular breast carcinoma and immunohistochemistry.

scholarly journals Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Gabriel M. Groisman
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Accessory Spleen ◽  
Extramedullary Hematopoiesis ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
Splenic Parenchyma ◽  
Lobular Breast Carcinoma ◽  
Accessory Spleens

Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.

Metastases from lobular breast cancer as an unusual source of GI bleeding.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12557-e12557
Author(s):  
Emily Clarke ◽  
James George ◽  
Andrew Peter Dean
Keyword(s):  
Breast Cancer ◽  
Abdominal Pain ◽  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Gi Bleeding ◽  
Lobular Breast Cancer ◽  
Gi Tract ◽  
Invasive Ductal Breast Carcinoma ◽  
Lobular Breast Carcinoma

e12557 Background: With the exception of malignant melanoma, metastases to the GI tract are rare, especially as a first presentation of malignancy. We report a series of patients with GI metastases from lobular breast carcinoma as an unusual source of symptomatic GI bleeding. Methods: We conducted an electronic database search to identify solid tumour patients (excluding melanoma) with metastases to the GI tract. We then analysed the database by tumour type. Results: 3 cases of proven metastasis to the GI tract were identified. All had lobular breast cancer metastases. The database contained 240 patients with breast cancer, identifying 63 with infiltrating lobular carcinoma, 2 with micropapillary and 175 with invasive ductal carcinoma The 1st case had had invasive ductal breast carcinoma 6 years previously and presented with fatigue and shortness of breath from anaemia. Colonoscopy revealed a polyp which was removed. Histopathology showed metastatic lobular breast carcinoma. Further investigation then confirmed an occult breast mass with identical pathology. The 2nd case presented with 18 months of abdominal pain, previous colonoscopy was normal. After onset of anaemia and 25kg weight loss, upper GI endoscopy showed a markedly thickened stomach with evidence of recent bleeding and biopsies confirmed metastatic lobular breast carcinoma. The 3rd case presented with abdominal pain, subsequent blood tests showing a raised CA125 with omental and ovarian masses. Surgical debulking showed metastatic lobular breast carcinoma, though no primary breast lesion was detectable with mammography, ultrasound and MRI. 3 years later, investigation of anaemia with colonoscopy showed a caecal polyp with histology confirming lobular breast carcinoma. Conclusions: Despite all common tumour types being represented in the database it is notable that all 3 cases with mucosal GI metastases had lobular breast cancer. Previous evidence suggests a long latent period from initial diagnosis of breast cancer to development of GI metastases however our report suggests it can occur earlier in the illness. Clinicians should consider this as a rare cause of GI bleeding and further research to understand the mechanism of mucosal metastasis in lobular breast cancer is needed.

Ultrasonography of invasive lobular breast carcinoma

1998 ◽  
Vol 39 (3) ◽  
pp. 285-291 ◽  
Author(s):  
T. Rissanen ◽  
T. Tikkakoski ◽  
A.-L. Autio ◽  
M. Apaja-Sarkkinen
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Architectural Distortion ◽  
Dense Breasts ◽  
The Us ◽  
Lobular Breast Carcinoma ◽  
Us Findings ◽  
Acoustic Shadowing

Purpose: To review the US findings in invasive lobular breast carcinoma which is often difficult to diagnose clinically and mammographically Material and Methods: The mammographic and US findings in 63 cases of pure invasive lobular carcinoma diagnosed at our institution in 1990-1996 were reviewed retrospectively. The US findings were classified as positive, negative or indeterminate for malignancy Results: Forty-nine of the 63 lobular carcinomas (78%, 95% CI 65.5-87.3%) were US-positive, and 51 (81%, CI 95% 69.1-89.8%) were mammography-positive. The US visibility of the carcinomas was affected by their palpability and mammographic appearance, and the radiographic density of the breasts. Indeterminate US findings (architectural distortion with acoustic shadowing) were visualized in 4 of the 10 cases that had asymmetric densities at mammography Conclusion: The sensitivity of US for lobular carcinoma was not statistically different from that of mammography. The methods were complementary, especially with regard to evaluating dense breasts and lesions which were difficult to assess clinically and mammographically

Lobular Carcinoma of the Breast Metastatic to the Oral Cavity Mimicking Polymorphous Low-Grade Adenocarcinoma of the Minor Salivary Glands

2000 ◽  
Vol 124 (1) ◽  
pp. 157-159
Author(s):  
Kathleen K. Nicol ◽  
Samy S. Iskandar
Keyword(s):  
Breast Carcinoma ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Steroid Receptors ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Metastatic Breast Carcinoma ◽  
Lobular Breast Carcinoma

Abstract The oral cavity is a rare site of metastatic lesions; however, metastatic breast carcinoma must be included in the differential diagnosis of tumors of that site in women. We describe a 54-year-old woman who presented with a lesion of the floor of the mouth that histologically resembled polymorphous low-grade adenocarcinoma of the minor salivary glands, which was eventually established to represent metastatic lobular breast carcinoma. The final diagnosis was based on comparison with a primary tumor resected 13 years earlier and immunohistochemical reactivity with antibodies to steroid receptors. Relevant aspects of lobular breast carcinoma, polymorphous low-grade adenocarcinoma, and metastatic oral cavity lesions are discussed.

Fine Needle Aspiration Cytology of Lobular Breast Carcinoma and Its Variants

2015 ◽  
Vol 59 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Rozany Mucha Dufloth ◽  
José Cândido Caldeira Xavier-Júnior ◽  
Francisco Alves Moraes Neto ◽  
Karina Janoti dos Santos ◽  
Fernando Schmitt
Keyword(s):  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Lobular Carcinoma ◽  
Needle Aspiration ◽  
Classical Type ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Lobular Breast Carcinoma ◽  
Needle Aspiration Cytology

Objective: To identify associations between cytological criteria in fine needle aspiration (FNA) specimens and histological subtypes of lobular breast carcinoma (classical and other types). Study Design: FNA cytology and mastectomy specimens from 72 cases of invasive lobular breast carcinoma were consecutively retrieved from the files of the Amaral de Carvalho Hospital, Jaú-São Paulo, Brazil. All cases were reviewed regarding five cytological criteria: cellularity, cellular cohesion, presence of inflammation, nucleoli and nuclear atypia. The χ2 test or Fisher's exact tests with 95% confidence intervals (CI) were used. Results: The classical type showed lower initial cytological diagnosis of malignancy compared to the other variants (p = 0.017; odds ratio (OR) 0.26, 95% CI 0.89-0.80). Moderate/intense cellular cohesion (p = 0.011; OR 0.18, 95% CI 0.04-0.73) and mild atypia (p = 0.000; OR 16.15, 95% CI 3.20-81.48) were significantly associated with the classical type of lobular breast carcinoma, while the absence of inflammation (p = 0.082; OR 0.36, 95% CI 0.12-1.15) was marginally associated with the classical type. Conclusions: In cytology, the characterization of lobular carcinoma as malignant is difficult, especially the classical type. The association between cell cohesion and the classical type of lobular breast carcinoma may be one of the factors that complicate this diagnosis.

scholarly journals Skin Nodules as a First Presentation of Synchronous Bilateral Invasive Lobular Breast Carcinoma: A Case Report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sara Khodair ◽  
Iman Ewais ◽  
Hanaa Abolmagd ◽  
Rehab El Sheikh ◽  
Sughra Raza ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Type Ii Diabetes ◽  
Lobular Carcinoma ◽  
Skin Lesions ◽  
Adult Women ◽  
Breast Lump ◽  
Skin Metastases ◽  
History Of ◽  
Skin Nodules ◽  
Lobular Breast Carcinoma

The most common cause of skin metastases in adult women is primary breast carcinoma, which comprises about 70% of cases [1]. Skin metastases have non-specific clinical appearances, making it challenging to differentiate them from other benign conditions [1]. We present a case of a 52-year-old female with type II diabetes and a three-month history of refractory skin lesions who did not respond to anti-inflammatory treatment. The patient subsequently complained of a right breast lump, evaluation of which led to the diagnosis of bilateral synchronous invasive lobular carcinoma.

scholarly journals Pathochistological and immunohistochemical study in small intestine metastasis as first clinical expression of invasive lobular breast carcinoma: Prognosis and complex treatment

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Lena Marinova ◽  
◽  
Bistra Yordanova ◽  
Nikolay Evgeniev ◽  
◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Target Therapy ◽  
Immunohistochemical Analysis ◽  
Emergency Operation ◽  
Complex Treatment ◽  
Oncological Treatment ◽  
Intestinal Neoplasm ◽  
Initial Symptoms ◽  
Lobular Breast Carcinoma ◽  
Gastrointestinal Metastases

The gastrointestinal metastases (GIM) of breast carcinoma (BC) are a rare clinical finding, even more rarely diagnosed as initial symptoms at unknown BC. We present a 50-year-old woman with metastases in the terminal ileum combined with multiple bone metastases from an unknown invasive carcinoma of left mammary gland. Gastrointestinal metastases are rarely observed in invasive lobular breast carcinoma. Differential diagnosis between intestinal metastases from primary BC and primary intestinal neoplasm is extremely difficult. Determination of tumor pathohistogenesis require careful pathohistological and immunohistochemical analysis. Complex treatment follows the primary neoplasm principles. The prognosis in such clinical cases is unfavorable, but after timely complex oncological treatment, including emergency operation, chemotherapy, hormone and target therapy, 36 monthly survival is achieved. Keywords: gastrointestinal metastases; invasive lobular breast carcinoma; pathohistological analysis; immunohistochemical analysis; complex treatment.

scholarly journals Metastatic Anal Lesion of Primary Lobular Breast Carcinoma- An Insidious, Rare and Subclinical Progression: Case Report and Review of the Literature

2020 ◽  
pp. 1-4
Author(s):  
Fabbri Nicolò ◽  
Aisoni F ◽  
Bonazza S ◽  
Carcoforo P ◽  
D’Urbano F ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Breast Carcinomas ◽  
Diagnostic Challenge ◽  
Disease Evolution ◽  
Metastatic Lesions ◽  
Long Time ◽  
Diagnostic Signs ◽  
Lobular Breast Carcinoma ◽  
Diagnostic Pathways

Gastrointestinal metastasis from primary breast carcinoma is very uncommon, with less than 1% of breast carcinomas metastasize to the gastrointestinal tract but anorectal involvement is even rarer. These metastatic lesions can lead to diagnostic challenge for clinicians as they can mimic primary colo-rectal cancer due to the lack of diagnostic signs. The increase of patient survival could lead to an unusual late resumption of metastatic disease, often for a long-time occult. Nowadays, an almost completely absent literature is unable to suggest diagnostic pathways capable of predicting this type of disease evolution. We present the case of a 76-year old woman who underwent treatment for an infiltrative lobular carcinoma of the breast who developed metastasis of the anal canal 11- years later. A literature review was performed.

Sign in / Sign up

Export Citation Format

Share Document