scholarly journals Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Gabriel M. Groisman
Keyword(s):  
Breast Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Accessory Spleen ◽  
Extramedullary Hematopoiesis ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
Splenic Parenchyma ◽  
Lobular Breast Carcinoma ◽  
Accessory Spleens

Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.

Lobular Carcinoma of the Breast Metastatic to the Oral Cavity Mimicking Polymorphous Low-Grade Adenocarcinoma of the Minor Salivary Glands

2000 ◽  
Vol 124 (1) ◽  
pp. 157-159
Author(s):  
Kathleen K. Nicol ◽  
Samy S. Iskandar
Keyword(s):  
Breast Carcinoma ◽  
Oral Cavity ◽  
Salivary Glands ◽  
Steroid Receptors ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Metastatic Breast Carcinoma ◽  
Lobular Breast Carcinoma

Abstract The oral cavity is a rare site of metastatic lesions; however, metastatic breast carcinoma must be included in the differential diagnosis of tumors of that site in women. We describe a 54-year-old woman who presented with a lesion of the floor of the mouth that histologically resembled polymorphous low-grade adenocarcinoma of the minor salivary glands, which was eventually established to represent metastatic lobular breast carcinoma. The final diagnosis was based on comparison with a primary tumor resected 13 years earlier and immunohistochemical reactivity with antibodies to steroid receptors. Relevant aspects of lobular breast carcinoma, polymorphous low-grade adenocarcinoma, and metastatic oral cavity lesions are discussed.

scholarly journals Occult Disseminated Metastatic Breast Carcinoma Presenting as Acquired Thrombotic Thrombocytopenic Purpura

2021 ◽  
pp. 1814-1820
Author(s):  
Siew Lian Chong ◽  
Asral Wirda Ahmad Asnawi ◽  
Roszymah Hamzah ◽  
Pek Kuen Liew ◽  
Tee Chuan Ong ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Hemolytic Anemia ◽  
Metastatic Breast ◽  
Metastatic Carcinoma ◽  
Blood Film ◽  
Thrombocytopenic Purpura ◽  
Metastatic Breast Carcinoma ◽  
Threatening Condition ◽  
Life Threatening

Cancer-related microangiopathic hemolytic anemia (MAHA) is a rare and life-threatening condition. We present a patient who had been treated for invasive lobular breast carcinoma in clinical remission with fever and hemolytic anemia. The peripheral blood film showed MAHA and thrombocytopenia, and a functional deficiency of ADAMTS13 activity of 23% consistent with acquired thrombotic thrombocytopenic purpura. Bone marrow aspirate and trephine biopsy confirmed metastatic carcinoma. Further evaluation revealed the involvement of multiple bone sites without recurrence of the primary tumor. The patient received a daily plasma exchange with cryosupernatant and was pulsed with corticosteroids. MAHA related to breast cancer appears to be a rare occurrence.

scholarly journals Biliary Dyskinesia as a Rare Presentation of Metastatic Breast Carcinoma of the Gallbladder: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
A. Markelov ◽  
H. Taheri ◽  
K. Vunnamadala ◽  
G. Ibrahim
Keyword(s):  
Breast Carcinoma ◽  
Invasive Lobular Carcinoma ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Rare Presentation ◽  
Metastatic Breast Carcinoma ◽  
Carcinoma Metastasis ◽  
Invasive Lobular Breast Cancer ◽  
The Brain ◽  
Common Malignancy

Background. Breast carcinoma is the most common malignancy in women worldwide. It is most commonly associated with metastases to the liver, lung, bone, and the brain. Invasive lobular carcinoma is a less common pathology with slightly higher metastases to the upper gastrointestinal tract. Invasive lobular carcinoma metastasis to the gallbladder is extremely rare.Method. In this paper we are presenting a case of a 67-year-old female with metastases of invasive lobular breast cancer to the gallbladder six years after her therapy.Conclusion. This case clearly signifies the nature of the micrometastatic foci of the invasive lobular carcinoma even many years after a successful treatment.

Acrokeratosis Paraneoplastica (Bazex Syndrome) Presenting in a Patient with Metastatic Breast Carcinoma: Possible Etiologic Role of Zinc

2007 ◽  
Vol 11 (2) ◽  
pp. 78-83 ◽  
Author(s):  
Muba Taher ◽  
Parbeer Grewal ◽  
Beth Gunn ◽  
Katia Tonkin ◽  
Gilles Lauzon
Keyword(s):  
Breast Carcinoma ◽  
Porphyria Cutanea Tarda ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Upper Aerodigestive Tract ◽  
Laboratory Findings ◽  
Metastatic Breast Carcinoma ◽  
Underlying Malignancy ◽  
Lobular Breast Carcinoma ◽  
Acrokeratosis Paraneoplastica Bazex

Background: Bazex syndrome (acrokeratosis paraneoplastica) is a rare paraneoplastic syndrome that usually occurs in males over 40 years old and is particularly associated with squamous cell carcinoma of the upper aerodigestive tract and adenopathy above the diaphragm. Objective: The objectives of our article are (1) to describe a unique case of acrokeratosis paraneoplastica and (2) to review the current literature regarding skin findings, commonly associated neoplasms, and treatment options relative to this condition. Patient: We describe a 68-year-old female with lobular breast carcinoma, complicated by local and distant recurrences, who presented with a 1-year history of prominent acral skin and nail changes. Results: Our patient's clinical skin findings improved significantly following treatment and partial remission of her underlying malignancy. Conclusions: Our patient represents one of few females described with this syndrome, which is especially rare in association with lobular breast carcinoma. Further, the patient's presentation is unique as she was discovered to demonstrate laboratory findings consistent with coexistent porphyria cutanea tarda and relative zinc deficiency.

Megakaryocytes Mimicking Metastatic Breast Carcinoma

2002 ◽  
Vol 126 (5) ◽  
pp. 618-620
Author(s):  
Syed A. Hoda ◽  
Erika Resetkova ◽  
Yasmin Yusuf ◽  
Anthony Cahan ◽  
Paul P. Rosen
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
False Positive Diagnosis ◽  
History Of ◽  
Von Willebrand ◽  
Willebrand Factor

Abstract False-positive diagnosis of lymph nodes occurs when a benign element in a lymph node, or in its capsule, is interpreted as metastatic carcinoma. This report describes a patient with breast carcinoma who had megakaryocytes in axillary sentinel lymph nodes mimicking metastatic carcinoma. The patient had no history of a hematologic disease, and we found no evidence of a concurrent hematopoietic disorder. The megakaryocytes were reactive for CD31, CD61, and von Willebrand factor, but not for cytokeratin (AE1/AE3). Megakaryocytes should be added to the list of benign histologic abnormalities that may simulate metastatic carcinoma in a sentinel lymph node.

scholarly journals Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation

2021 ◽  
Vol 8 (2) ◽  
pp. C32-34
Author(s):  
Maymol P Varghese ◽  
Sreeja Raju ◽  
Savithri MC ◽  
Joy Augustine ◽  
Mathew Varghese
Keyword(s):  
Breast Carcinoma ◽  
Uterine Cervix ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Present Case Report ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
A Site

Uterine cervix involvement as a site of metastasis from a distant primary tumor is rare. Metastasis from breast carcinoma in a patient undergoing treatment is even rarer.  The present case report is of a 47-year-old lady with history of carcinoma breast on treatment and who was referred to our hospital with complaints of lower limb oedema, low backache and postmenopausal whitish discharge per vaginum. Per vaginal examination revealed a lesion arising in the cervix extending up to the anterior vaginal wall suggestive of a clinical diagnosis of carcinoma cervix. Subsequent biopsy from the lesion showed malignant cells arranged in Indian file pattern and focal alveolar pattern, hinting at a diagnosis of Invasive lobular carcinoma metastasis.  The neoplasm was positive for ER, PR and GATA-3 and negative for Her2/neu and E-cadherin confirming our diagnosis. Although rare, the poor outcome in such patients makes it even more important for its identification and the need for them to undergo careful routine gynecologic examination.

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