Associations of objectively and subjectively measured physical activity with trabecular and cortical bone properties in prepubertal children

Objectives. To compare the relationship between peak bone strain scores (PBSSs) calculated from physical activity (PA) questionnaires and accelerometry measures of PA with trabecular and cortical bone properties in prepubertal children.Methods. We compared PBSSs calculated from the bone-specific component of PA questionnaires with accelerometry and bone mass measures in 38 prepubertal children (mean 9.9 (standard deviation 1.3) years). Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) were used to assess bone content and structure, and to estimate bone strength at the radial and tibial diaphysis and radial metaphysis. Results. The PBSS was reliable and reproducible with significant (p<0.001) intraclass correlation coefficients. There were significant correlations between PBSS and moderate (r=0.38; p=0.02), vigorous (r=0.36; p=0.03) and combined moderate- to vigorous-intensity activity counts (r=0.38; p=0.02). PBSS was significantly correlated to body size-adjusted bone mineral content at all sites scanned by DXA (r=0.33 - 0.48; p<0.05). Positive correlations were observed between PBSS and area, density and strength at the radius and tibia (r=0.40 - 0.64; p<0.05). Only vigorous activity was correlated to cortical area at the radial diaphysis (r=0.37; p=0.03) and bone strength at the tibial diaphysis (r=0.32; p=0.05). Activity as assessed by the PBSS explained a greater amount of variance in bone variables as measured by DXA and pQCT than accelerometer-measured PA. Conclusion. Accelerometer-measured moderate and vigorous habitual PA is associated with indices of cortical bone size and geometry in children, whereas light PA has no detectable association. Furthermore, the bone-specific questionnaire appears to be more strongly associated with bone outcomes than accelerometer-derived measures of PA.

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The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18105365 ◽

2021 ◽

Vol 18 (10) ◽

pp. 5365

Author(s):

Annie M. Constable ◽

Josie E. Porter ◽

Danielle Benger ◽

Dimitris Vlachopoulos ◽

Alan R. Barker ◽

...

Keyword(s):

Physical Activity ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Vigorous Physical Activity ◽

Normal Weight ◽

Cross Sectional ◽

Prepubertal Children ◽

Total Body ◽

The Relationship

Purpose: Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children. Methods: We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry. Results: MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = −0.000 to 0.001, p > 0.05). Conclusion: Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.

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Reduced physical activity corresponds with greater bone loss at the trabecular than the cortical bone sites in men

Bone ◽

10.1016/j.bone.2009.07.007 ◽

2009 ◽

Vol 45 (6) ◽

pp. 1073-1078 ◽

Cited By ~ 15

Author(s):

Taru Tervo ◽

Peter Nordström ◽

Martin Neovius ◽

Anna Nordström

Keyword(s):

Physical Activity ◽

Bone Loss ◽

Cortical Bone ◽

Reduced Physical Activity

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Habitual levels of vigorous physical activity as measured by accelerometry are positively related to cortical bone mass in adolescence, whereas no association is seen with moderate or light activity

Bone ◽

10.1016/j.bone.2010.04.217 ◽

2010 ◽

Vol 47 ◽

pp. S103-S104

Author(s):

A. Sayers ◽

J.H. Tobias

Keyword(s):

Physical Activity ◽

Bone Mass ◽

Cortical Bone ◽

Vigorous Physical Activity ◽

Light Activity ◽

Cortical Bone Mass

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Bone properties of rats treated with fluoride in combination with mechanical stress due to physical activity

Bone ◽

10.1016/j.bone.2014.12.029 ◽

2016 ◽

Vol 83 ◽

pp. 276-277

Author(s):

V.I. Garcia ◽

B.L. Fina ◽

M. Lombarte ◽

A. Rigalli

Keyword(s):

Physical Activity ◽

Mechanical Stress ◽

Bone Properties

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Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice

Scientific Reports ◽

10.1038/s41598-020-79098-0 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Haisheng Yang ◽

Alexander Büttner ◽

Laia Albiol ◽

Catherine Julien ◽

Tobias Thiele ◽

...

Keyword(s):

Physical Activity ◽

Bone Formation ◽

Bone Mass ◽

Cortical Bone ◽

Bone Adaptation ◽

Moderate Level ◽

Skeletal Maturation ◽

Male Mice ◽

Males And Females

AbstractLoss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis. Questions remain as to how physical activity may affect bone mass under sclerostin inhibition and if that effect differs between males and females. We previously observed in female Sost knockout (KO) mice an enhanced cortical bone formation response to a moderate level of applied loading (900 με at the tibial midshaft). The purpose of the present study was to examine cortical bone adaptation to the same strain level applied to male Sost KO mice. Strain-matched in vivo compressive loading was applied to the tibiae of 10-, 26- and 52-week-old male Sost KO and littermate control (LC) mice. The effect of tibial loading on bone (re)modeling was measured by microCT, 3D time-lapse in vivo morphometry, 2D histomorphometry and gene expression analyses. As expected, Sost deficiency led to high cortical bone mass in 10- and 26-week-old male mice as a result of increased bone formation. However, the enhanced bone formation associated with Sost deficiency did not appear to diminish with skeletal maturation. An increase in bone resorption was observed with skeletal maturation in male LC and Sost KO mice. Two weeks of in vivo loading (900 με at the tibial midshaft) induced only a mild anabolic response in 10- and 26-week-old male mice, independent of Sost deficiency. A decrease in the Wnt inhibitor Dkk1 expression was observed 3 h after loading in 52-week-old Sost KO and LC mice, and an increase in Lef1 expression was observed 8 h after loading in 10-week-old Sost KO mice. The current results suggest that long-term inhibition of sclerostin in male mice does not influence the adaptive response of cortical bone to moderate levels of loading. In contrast with our previous strain-matched study in females showing enhanced bone responses with Sost ablation, these results in males indicate that the influence of Sost deficiency on the cortical bone formation response to a moderate level of loading differs between males and females. Clinical studies examining antibodies to inhibit sclerostin may need to consider that the efficacy of additional physical activity regimens may be sex dependent.

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