scholarly journals Associations of objectively and subjectively measured physical activity with trabecular and cortical bone properties in prepubertal children

2014 ◽  
Vol 26 (2) ◽  
pp. 48
Author(s):  
Rebecca Mary Meiring ◽  
Joanne Alexandra McVeigh
Keyword(s):  
Physical Activity ◽  
Cortical Bone ◽  
Bone Strength ◽  
Intraclass Correlation ◽  
Quantitative Computed Tomography ◽  
Correlation Coefficients ◽  
Peripheral Quantitative Computed Tomography ◽  
Prepubertal Children ◽  
Tibial Diaphysis ◽  
Bone Properties

Objectives. To compare the relationship between peak bone strain scores (PBSSs) calculated from physical activity (PA) questionnaires and accelerometry measures of PA with trabecular and cortical bone properties in prepubertal children.Methods. We compared PBSSs calculated from the bone-specific component of PA questionnaires with accelerometry and bone mass measures in 38 prepubertal children (mean 9.9 (standard deviation 1.3) years). Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) were used to assess bone content and structure, and to estimate bone strength at the radial and tibial diaphysis and radial metaphysis. Results. The PBSS was reliable and reproducible with significant (p<0.001) intraclass correlation coefficients. There were significant correlations between PBSS and moderate (r=0.38; p=0.02), vigorous (r=0.36; p=0.03) and combined moderate- to vigorous-intensity activity counts (r=0.38; p=0.02). PBSS was significantly correlated to body size-adjusted bone mineral content at all sites scanned by DXA (r=0.33 - 0.48; p<0.05). Positive correlations were observed between PBSS and area, density and strength at the radius and tibia (r=0.40 - 0.64; p<0.05). Only vigorous activity was correlated to cortical area at the radial diaphysis (r=0.37; p=0.03) and bone strength at the tibial diaphysis (r=0.32; p=0.05). Activity as assessed by the PBSS explained a greater amount of variance in bone variables as measured by DXA and pQCT than accelerometer-measured PA. Conclusion. Accelerometer-measured moderate and vigorous habitual PA is associated with indices of cortical bone size and geometry in children, whereas light PA has no detectable association. Furthermore, the bone-specific questionnaire appears to be more strongly associated with bone outcomes than accelerometer-derived measures of PA.

scholarly journals Reliability and Change in Erosion Measurements by High-Resolution peripheral Quantitative Computed Tomography in a Longitudinal Dataset of Rheumatoid Arthritis Patients

2020 ◽  
pp. jrheum.191391 ◽  
Author(s):  
Stephanie Finzel ◽  
Sarah L. Manske ◽  
Cheryl Barnabe ◽  
Andrew J. Burghardt ◽  
Hubert Marotte ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
High Resolution ◽  
Intraclass Correlation ◽  
Quantitative Computed Tomography ◽  
Correlation Coefficients ◽  
Peripheral Quantitative Computed Tomography ◽  
Good Reliability ◽  
Change Over Time ◽  
Over Time

Objective The aim of this multi-reader exercise was to assess the reliability and change over time of erosion measurements in rheumatoid arthritis (RA) patients using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods HR-pQCT scans of 23 patients with RA were assessed at baseline and 12 months. Four experienced readers examined the dorsal, palmar, radial, and ulnar surfaces of the metacarpal head (MH) and phalangeal base (PB) of the 2nd and 3rd digits, blinded to time order. In total, 368 surfaces (23 patients x16 surfaces) were evaluated per time point to characterize cortical breaks as pathological (erosion) or physiological, and to quantify erosion width and depth. Reliability was evaluated by intraclass correlation coefficients (ICC), percentage agreement, and Light’s kappa; change over time was defined by means ± SD of erosion numbers and dimensions. Results ICCs for the mean measurements of width and depth of the pathological breaks ranged between 0.819 - 0.883, and 0.771 - 0.907 respectively. Most physiological cortical breaks were found at the palmar PB, whereas most pathological cortical breaks were located at the radial MH. There was a significant increase in both the numbers and the dimensions of erosions between baseline and follow-up (p=0.0001 for erosion numbers, width, and depth in axial plane, and p=0.001 for depth in perpendicular plane). Conclusion This exercise confirmed good reliability of HR-pQCT erosion measurements and their ability to detect change over time.

scholarly journals Moderate to vigorous physical activity and impact loading independently predict variance in bone strength at the tibia but not at the radius in children

2019 ◽  
Vol 44 (3) ◽  
pp. 326-331 ◽  
Author(s):  
Anthony M. Kehrig ◽  
Kelsey M. Björkman ◽  
Nazeem Muhajarine ◽  
James D. Johnston ◽  
Saija A. Kontulainen
Keyword(s):  
Physical Activity ◽  
Bone Strength ◽  
Vigorous Physical Activity ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Children And Youth ◽  
Strength Development ◽  
Linear Regression Models ◽  
Muscle Area ◽  
Objective Recording

The objectives of this study were (i) to assess whether daily minutes of moderate to vigorous physical activity (MVPA) or vigorous physical activity (VPA) and impact counts (acceleration peaks ≥3.9g) independently predict variance in bone strength in children and youth and (ii) to estimate bone strength gain associated with increases in daily MVPA, VPA, or impact counts. We recorded 7-day activity of 49 participants (mean age 11.0 years, SD 1.7) using accelerometers and estimated radius and tibia bone strength using peripheral quantitative computed tomography. We used linear regression models adjusted for sex, body mass, and muscle area to address our objectives. Daily MVPA (mean 50 min, SD 23) and VPA (mean 17 min, SD 11) or impacts (mean 71 counts, SD 59) did not predict variance in radius strength. Daily VPA (β = 0.24) predicted variance in tibia strength at the distal and shaft sites, and shaft strength was also predicted by MVPA (β = 0.20) and impact counts (β = 0.21). Our models estimated a 3%–6%, 4%, or 4%–11% gain in tibia strength after increasing daily MVPA by 10–20 min, VPA by 5 min, or impacts by 30–100 counts, respectively. In conclusion, daily minutes of MVPA or VPA and impact counts are independent predictors of tibia but not radius strength. Objective recording of activities associated with forearm bone strength and trials testing the efficacy of increasing daily MVPA, VPA, and related impacts on bone strength development in children and youth are warranted.

Definition for Rheumatoid Arthritis Erosions Imaged with High Resolution Peripheral Quantitative Computed Tomography and Interreader Reliability for Detection and Measurement

2016 ◽  
Vol 43 (10) ◽  
pp. 1935-1940 ◽  
Author(s):  
Cheryl Barnabe ◽  
Dominique Toepfer ◽  
Hubert Marotte ◽  
Ellen-Margrethe Hauge ◽  
Andrea Scharmga ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
High Resolution ◽  
Cortical Bone ◽  
Intraclass Correlation ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Maximum Width ◽  
Trabecular Bone Loss ◽  
Axial Depth

Objective.High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic cortical bone disruptions in RA and to standardize reference landmarks for measuring erosion size.Methods.HR-pQCT images of metacarpophalangeal joints of RA and control subjects were used in an iterative process to achieve consensus on the definition and reference landmarks. Independent readers (n = 11) applied the definition to score 58 joints and measure pathologic erosions in 2 perpendicular multiplanar reformations for their maximum width and depth. Interreader reliability for erosion detection and variability in measurements between readers [root mean square coefficient of variation (RMSCV), intraclass correlation (ICC)] were calculated.Results.Pathologic erosions were defined as cortical breaks extending over a minimum of 2 consecutive slices in perpendicular planes, with underlying trabecular bone loss and a nonlinear shape. Interreader agreement for classifying pathologic erosions was 90.2%, whereas variability for width and depth erosion assessment was observed (RMSCV perpendicular width 12.3%, axial width 20.6%, perpendicular depth 24.0%, axial depth 22.2%; ICC perpendicular width 0.206, axial width 0.665, axial depth 0.871, perpendicular depth 0.783). Mean erosion width was 1.84 mm (range 0.16–8.90) and mean depth was 1.86 mm (range 0.30–8.00).Conclusion.We propose a new definition for erosions visualized with HR-pQCT imaging. Interreader reliability for erosion detection is good, but further refinement of selection of landmarks for erosion size measurement, or automated volumetric methods, will be pursued.

scholarly journals Standardising the measurement of physical activity in people receiving haemodialysis: considerations for research and practice

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Hannah M. L. Young ◽  
Mark W. Orme ◽  
Yan Song ◽  
Maurice Dungey ◽  
James O. Burton ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sample Size ◽  
Repeated Measures ◽  
A Priori ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Future Research ◽  
Wear Time ◽  
Minimum Number ◽  
The Uk

Abstract Background Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurement of PA using accelerometers is increasing, but standard reporting guidelines essential to effectively evaluate, compare and synthesise the effects of PA interventions are lacking. This study aims to (i) determine the measurement and processing guidance required to ensure representative PA data amongst a diverse HD population, and; (ii) to assess adherence to PA monitor wear amongst HD patients. Methods Clinically stable HD patients from the UK and China wore a SenseWear Armband accelerometer for 7 days. Step count between days (HD, Weekday, Weekend) were compared using repeated measures ANCOVA. Intraclass correlation coefficients (ICCs) determined reliability (≥0.80 acceptable). Spearman-Brown prophecy formula, in conjunction with a priori ≥  80% sample size retention, identified the minimum number of days required for representative PA data. Results Seventy-seven patients (64% men, mean ± SD age 56 ± 14 years, median (interquartile range) time on HD 40 (19–72) months, 40% Chinese, 60% British) participated. Participants took fewer steps on HD days compared with non-HD weekdays and weekend days (3402 [95% CI 2665–4140], 4914 [95% CI 3940–5887], 4633 [95% CI 3558–5707] steps/day, respectively, p < 0.001). PA on HD days were less variable than non-HD days, (ICC 0.723–0.839 versus 0.559–0.611) with ≥ 1 HD day and ≥  3 non-HD days required to provide representative data. Using these criteria, the most stringent wear-time retaining ≥ 80% of the sample was ≥7 h. Conclusions At group level, a wear-time of ≥7 h on ≥1HD day and ≥ 3 non-HD days is required to provide reliable PA data whilst retaining an acceptable sample size. PA is low across both HD and non- HD days and future research should focus on interventions designed to increase physical activity in both the intra and interdialytic period.

Using Pedometers to Estimate Ambulatory Physical Activity in Vietnam

2011 ◽  
Vol 8 (1) ◽  
pp. 52-61 ◽  
Author(s):  
Au Bich Thuy ◽  
Leigh Blizzard ◽  
Michael Schmidt ◽  
Costan Magnussen ◽  
Emily Hansen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Concurrent Validity ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Population Based ◽  
Work Activities ◽  
Intraclass Correlation Coefficients ◽  
Significant Difference ◽  
Day Of The Week ◽  
Population Based Survey

Background:Pedometer measurement of physical activity (PA) has been shown to be reliable and valid in industrialized populations, but its applicability in economically developing Vietnam remains untested. This study assessed the feasibility, stability and validity of pedometer estimates of PA in Vietnam.Methods:250 adults from a population-based survey were randomly selected to wear Yamax pedometers and record activities for 7 consecutive days. Stability and concurrent validity were assessed using intraclass correlation coefficients (ICC) and Spearman correlation coefficients.Results:Overall, 97.6% of participants provided at least 1 day of usable recordings, and 76.2% wore pedometers for all 7 days. Only 5.2% of the sample participants were involved in work activities not measurable by pedometer. The number of steps increased with hours of wear. There was no significant difference between weekday and weekend in number of steps, and at least 3 days of recordings were required (ICC of the 3 days of recordings: men 0.96, women 0.97). Steps per hour were moderately correlated (men r = .42, women r = .26) with record estimates of total PA.Conclusions:It is feasible to use pedometers to estimate PA in Vietnam. The measure should involve at least 3 days of recording irrespective of day of the week.

scholarly journals Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Shreyasee Amin ◽  
Sundeep Khosla
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Bone Strength ◽  
Bone Biopsy ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
Older Men ◽  
Peripheral Quantitative Computed Tomography ◽  
Men And Women ◽  
Age Related

The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women.

Measuring Physical Activity in Juvenile Idiopathic Arthritis: Activity Diary Versus Accelerometer

2017 ◽  
Vol 44 (8) ◽  
pp. 1249-1256 ◽  
Author(s):  
Wineke Armbrust ◽  
G.J.F. Joyce Bos ◽  
Jan H.B. Geertzen ◽  
Pieter J.J. Sauer ◽  
Pieter U. Dijkstra ◽  
...  
Keyword(s):  
Physical Activity ◽  
Juvenile Idiopathic Arthritis ◽  
Effect Size ◽  
Convergent Validity ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Accelerometer Data ◽  
Individual Level ◽  
Intraclass Correlation Coefficients ◽  
Activity Diary

Objective.(1) To determine convergent validity of an activity diary (AD) and accelerometer (Actical brand/Phillips-Respironics) in measuring physical activity (PA) in children with juvenile idiopathic arthritis (JIA). (2) To determine how many days give reliable results. (3) To analyze effects of correcting accelerometer data for non-wear.Methods.Patients with JIA (8–13 yrs) were recruited from 3 Dutch pediatric rheumatology centers. PA was assessed for 7 days with an AD and accelerometer, and was expressed as mean min/day of rest, light PA (LPA), moderate to vigorous PA (MVPA), and PA level (PAL). To analyze convergent validity, intraclass correlation coefficients (ICC) were calculated and paired sample Student t tests were performed. The required number of days to achieve reliable results was calculated using the Spearman-Brown prophecy formula.Results.Convergent validity between AD and accelerometer was moderate for rest and PAL (ICC 0.41). ICC for LPA and MVPA were < 0.24. AD overestimated PAL and MVPA compared with the accelerometer. Wearing the accelerometer 7–19 days gave reliable PA estimates on group and individual levels. For the AD, 13–36 days were needed. Adjusting accelerometer data for non-wear resulted in a clinically relevant higher mean number of min/day spent in LPA (effect size 1.12), but not in MVPA (effect size 0.44).Conclusion.Convergent validity between AD and accelerometer is moderate to poor. In children with JIA, 1-week assessment with an accelerometer is sufficient to measure PA (all levels) reliably. On an individual level and for clinical use, 3 weeks are required. Additional use of AD enables correction for non-wear of accelerometer data.

Sign in / Sign up

Export Citation Format

Share Document