scholarly journals Decision letter: miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

2014 ◽  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Human Breast Cancer ◽  
Wnt Signaling Pathway ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Canonical Wnt

scholarly journals Author response: miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

2014 ◽  
Author(s):  
Taichi Isobe ◽  
Shigeo Hisamori ◽  
Daniel J Hogan ◽  
Maider Zabala ◽  
David G Hendrickson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Human Breast Cancer ◽  
Wnt Signaling Pathway ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Canonical Wnt

scholarly journals miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Taichi Isobe ◽  
Shigeo Hisamori ◽  
Daniel J Hogan ◽  
Maider Zabala ◽  
David G Hendrickson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Human Breast Cancer ◽  
Wnt Signaling Pathway ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Canonical Wnt

MicroRNAs (miRNAs) are important regulators of stem and progenitor cell functions. We previously reported that miR-142 and miR-150 are upregulated in human breast cancer stem cells (BCSCs) as compared to the non-tumorigenic breast cancer cells. In this study, we report that miR-142 efficiently recruits the APC mRNA to an RNA-induced silencing complex, activates the canonical WNT signaling pathway in an APC-suppression dependent manner, and activates the expression of miR-150. Enforced expression of miR-142 or miR-150 in normal mouse mammary stem cells resulted in the regeneration of hyperproliferative mammary glands in vivo. Knockdown of endogenous miR-142 effectively suppressed organoid formation by BCSCs and slowed tumor growth initiated by human BCSCs in vivo. These results suggest that in some tumors, miR-142 regulates the properties of BCSCs at least in part by activating the WNT signaling pathway and miR-150 expression.

scholarly journals Abstract 2890: MicroRNA-mediated upregulation of the WNT signaling activities in human breast cancer stem cells

2017 ◽  
Author(s):  
Yohei Shimono ◽  
Taichi Isobe ◽  
Andrei Turtoi ◽  
Junko Mukohyama ◽  
Toru Mukohara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast

scholarly journals Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells

2020 ◽  
Vol 21 (11) ◽  
pp. 3171-3176
Author(s):  
Soroush Darbankhales ◽  
Reza Mirfakhraie ◽  
Hossein Ghahremani ◽  
Mohsen Asadolahi ◽  
Kobra Saket-Kisomi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Signaling Pathway ◽  
Human Breast Cancer ◽  
Hippo Signaling ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Hippo Signaling Pathway

scholarly journals MicroRNA Regulation of Human Breast Cancer Stem Cells

2015 ◽  
Vol 5 (1) ◽  
pp. 2 ◽  
Author(s):  
Yohei Shimono ◽  
Junko Mukohyama ◽  
Shun-ichi Nakamura ◽  
Hironobu Minami
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Microrna Regulation

scholarly journals Anticancer Activities of the Methanolic Extract from Lemon Leaves in Human Breast Cancer Stem Cells

2015 ◽  
Vol 58 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Jeong Yong Moon ◽  
Linh Thi Thao Nguyen ◽  
Ho Bong Hyun ◽  
Ahmed Osman ◽  
Minwhan Cho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Methanolic Extract ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Anticancer Activities

Abstract A54: STAT3 as a novel therapeutic target in human breast cancer stem cells

2009 ◽  
Author(s):  
Li Lin ◽  
Brian Hutzen ◽  
Zhengang Peng ◽  
Huey‐Jen Lin ◽  
Pui‐Kai Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Target ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Novel Therapeutic

scholarly journals Let-7: A regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells

2013 ◽  
Vol 29 (5) ◽  
pp. 2079-2087 ◽  
Author(s):  
XIN SUN ◽  
SIDA QIN ◽  
CHONG FAN ◽  
CHONGWEN XU ◽  
NING DU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Signaling Pathway ◽  
Breast Tumors ◽  
Breast Cancer Stem Cells ◽  
Human Breast

scholarly journals Correction: In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247694
Author(s):  
Septelia Inawati Wanandi ◽  
Agus Limanto ◽  
Elvira Yunita ◽  
Resda Akhra Syahrani ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
In Silico ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Anti Cancer ◽  
Cancer Activity
Sign in / Sign up

Export Citation Format

Share Document