scholarly journals Author response: Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

2015 ◽  
Author(s):  
Aida Rodrigo Albors ◽  
Akira Tazaki ◽  
Fabian Rost ◽  
Sergej Nowoshilow ◽  
Osvaldo Chara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Cell Polarity ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Planar Cell Polarity ◽  
Author Response ◽  
Spinal Cord Regeneration ◽  
Stem Cell Expansion

scholarly journals Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Aida Rodrigo Albors ◽  
Akira Tazaki ◽  
Fabian Rost ◽  
Sergej Nowoshilow ◽  
Osvaldo Chara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Cell Polarity ◽  
Neural Stem Cell ◽  
Planar Cell Polarity ◽  
Spinal Cord Regeneration ◽  
Mitotic Spindles ◽  
Cell Cycles

Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and reactivate a transcriptional program similar to embryonic neuroepithelial cells. This dedifferentiation includes the acquisition of rapid cell cycles, the switch from neurogenic to proliferative divisions, and the re-expression of planar cell polarity (PCP) pathway components. We show that PCP induction is essential to reorient mitotic spindles along the anterior-posterior axis of elongation, and orthogonal to the cell apical-basal axis. Disruption of this property results in premature neurogenesis and halts regeneration. Our findings reveal a key role for PCP in coordinating the morphogenesis of spinal cord outgrowth with the switch from a homeostatic to a regenerative stem cell that restores missing tissue.

scholarly journals Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

2013 ◽  
Vol 12 (1) ◽  
pp. 88-100 ◽  
Author(s):  
M. Ángeles Marqués-Torrejón ◽  
Eva Porlan ◽  
Ana Banito ◽  
Esther Gómez-Ibarlucea ◽  
Andrés J. Lopez-Contreras ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
Adult Neural Stem Cell ◽  
Stem Cell Expansion ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Sox2 Gene

scholarly journals MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

Cell Reports ◽  
2013 ◽  
Vol 3 (5) ◽  
pp. 1398-1406 ◽  
Author(s):  
Shan Bian ◽  
Janet Hong ◽  
Qingsong Li ◽  
Laura Schebelle ◽  
Andrew Pollock ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Intermediate Progenitors ◽  
Microrna Cluster

scholarly journals Insulin-like Growth Factor-II (IGF-II) and IGF-II Analogs with Enhanced Insulin Receptor-a Binding Affinity Promote Neural Stem Cell Expansion

2014 ◽  
Vol 289 (8) ◽  
pp. 4626-4633 ◽  
Author(s):  
Amber N. Ziegler ◽  
Shravanthi Chidambaram ◽  
Briony E. Forbes ◽  
Teresa L. Wood ◽  
Steven W. Levison
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Insulin Receptor ◽  
Binding Affinity ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Insulin Like Growth Factor ◽  
Stem Cell Expansion ◽  
Factor Ii

scholarly journals Transcriptional regulation of neural stem cell expansion in adult hippocampus

2021 ◽  
Author(s):  
Nannan Guo ◽  
Kelsey McDermott ◽  
Yu-Tzu Shih ◽  
Haley Zanga ◽  
Debolina Ghosh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Self Renewal ◽  
Stem Cell Expansion ◽  
Radial Glial ◽  
Adult Hippocampus ◽  
Favorable Conditions

Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors in RGLs integrate physiological signals to dictate self-renewal division mode. Whereas asymmetric RGL divisions drive neurogenesis during favorable conditions, symmetric divisions prevent premature neurogenesis while amplifying RGLs to anticipate future neurogenic demands. The identities of transcription factors regulating RGL symmetric self-renewal, unlike those that regulate RGL asymmetric self-renewal, are not known. Here, we show that the transcription factor Kruppel-like factor 9 (Klf9) is elevated in quiescent RGLs and inducible, deletion of Klf9 promotes RGL activation state. Clonal analysis and longitudinal intravital 2-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo translational profiling of RGLs lacking Klf9 generated a blueprint of RGL symmetric self-renewal for stem cell community. Together, these observations identify Klf9 as a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

scholarly journals Promotion of Spinal Cord Regeneration by Neural Stem Cell-Secreted Trimerized Cell Adhesion Molecule L1

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e46223 ◽  
Author(s):  
Xiaowen He ◽  
Michael Knepper ◽  
Cheng Ding ◽  
Jun Li ◽  
Suita Castro ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cell ◽  
Cell Adhesion ◽  
Neural Stem Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Spinal Cord Regeneration ◽  
Cell Adhesion Molecule L1

scholarly journals The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Chan-Il Choi ◽  
Hyesook Yoon ◽  
Kristen L. Drucker ◽  
Monica R. Langley ◽  
Laurel Kleppe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Cell Expansion ◽  
Thrombin Receptor ◽  
Stem Cell Expansion
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