scholarly journals Updates to the zoonotic niche map of Ebola virus disease in Africa

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
David M Pigott ◽  
Anoushka I Millear ◽  
Lucas Earl ◽  
Chloe Morozoff ◽  
Barbara A Han ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Reservoir Species ◽  
Surveillance And Response ◽  
Prediction And Prevention ◽  
Zoonotic Risk ◽  
Response Capacity ◽  
Date Estimate ◽  
Data Portal

As the outbreak of Ebola virus disease (EVD) in West Africa is now contained, attention is turning from control to future outbreak prediction and prevention. Building on a previously published zoonotic niche map (<xref ref-type="bibr" rid="bib27">Pigott et al., 2014</xref>), this study incorporates new human and animal occurrence data and expands upon the way in which potential bat EVD reservoir species are incorporated. This update demonstrates the potential for incorporating and updating data used to generate the predicted suitability map. A new data portal for sharing such maps is discussed. This output represents the most up-to-date estimate of the extent of EVD zoonotic risk in Africa. These maps can assist in strengthening surveillance and response capacity to contain viral haemorrhagic fevers.

The epidemiological characteristics of Ebola virus disease

2018 ◽  
Vol 6 (1) ◽  
pp. 1-18
Author(s):  
Brian S.Singer ◽  
Stefan K Blinov
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Emerging Infectious Diseases ◽  
Central Africa ◽  
Ebola Virus Disease ◽  
Effective Control ◽  
Public Health Response ◽  
Surveillance And Response ◽  
Health Response ◽  
Epidemiological Characteristics

Ebola was first reported in 1976 in Sudan and Congo and named after the river where it was identified. They cause fulminating disease characterized by acute fever followed by generalized hemorrhagic syndrome that is associated with 90% mortality in the most severe forms. It was later reported in Gabon, Central Africa and between 2 and 4 August 2014, a total of 108 new cases of Ebola virus disease (EVD) (laboratory-confirmed, probable, and suspect cases) as well as 45 deaths were reported from Guinea, Liberia, Nigeria, and Sierra Leone. Surveillance and response represent the final crucial steps in achieving effective control of Ebola virus disease, it should be followed by an effective public health response – delivered as integrated packages – with the purpose to interrupt transmission in well defined areas. In addition, intensive efficacy and pharmacovigilance assessment of these interventions including diagnostics, drugs and vaccines against Ebola and other emerging infectious diseases including NTDs must be carefully re-evaluated, and the cut-offs determined and monitored over time, in addition to enhance cross-border collaboration and strengthen effective coordination across African government and populations. Control interventions were very successful in containing the epidemic of EVD.

scholarly journals Revitalization of integrated disease surveillance and response in Sierra Leone post Ebola virus disease outbreak

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Charles Njuguna ◽  
Amara Jambai ◽  
Alexander Chimbaru ◽  
Anders Nordstrom ◽  
Roland Conteh ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Disease Surveillance ◽  
Ebola Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
Ebola Virus Disease ◽  
Surveillance And Response

scholarly journals The implementation of integrated disease surveillance and response in Liberia after Ebola virus disease outbreak 2015-2017

2019 ◽  
Vol 33 ◽  
Author(s):  
Thomas Nagbe ◽  
Jeremias Domingos Naiene ◽  
Julius Monday Rude ◽  
Nuha Mahmoud ◽  
Mohammed Kromah ◽  
...  
Keyword(s):  
Disease Surveillance ◽  
Ebola Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
Ebola Virus Disease ◽  
Surveillance And Response

scholarly journals Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo

2021 ◽  
Vol 15 (8) ◽  
pp. e0009566
Author(s):  
Anna Bratcher ◽  
Nicole A. Hoff ◽  
Reena H. Doshi ◽  
Adva Gadoth ◽  
Megan Halbrook ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ebola Virus ◽  
Democratic Republic Of Congo ◽  
Virus Disease ◽  
Severe Disease ◽  
Asymptomatic Infection ◽  
Ebola Virus Disease ◽  
Factors Associated ◽  
Bodily Fluids ◽  
Zoonotic Risk

Background Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EVD can have detectable EBOV antigen-specific antibodies in their blood. This study aims to identify risk factors associated with detectable antibody levels in the absence of an EVD diagnosis. Methodology Data was collected from September 2015 to August 2017 from 1,366 consenting individuals across four study sites in the DRC (Boende, Kabondo-Dianda, Kikwit, and Yambuku). Seroreactivity was determined to EBOV GP IgG using Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA kits (Alpha Diagnostic International, Inc.) in Kinshasa, DRC; any result above 4.7 units/mL was considered seroreactive. Among the respondents, 113 (8.3%) were considered seroreactive. Several zoonotic exposures were associated with EBOV seroreactivity after controlling for age, sex, healthcare worker status, location, and history of contact with an EVD case, namely: ever having contact with bats, ever having contact with rodents, and ever eating non-human primate meat. Contact with monkeys or non-human primates was not associated with seroreactivity. Conclusions This analysis suggests that some zoonotic exposures that have been linked to EVD outbreaks can also be associated with EBOV GP seroreactivity in the absence of diagnosed EVD. Future investigations should seek to clarify the relationships between zoonotic exposures, seroreactivity, asymptomatic infection, and EVD.

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