scholarly journals MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Flavio H Beraldo ◽  
Daniel Palmer ◽  
Sara Memar ◽  
David I Wasserman ◽  
Wai-Jane V Lee ◽  
...  

Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer’s disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.

2019 ◽  
Author(s):  
Matheus Pereira Lobo

This is an open microarticle. We are issuing an open invitation for new contributions to this article in order to join forces and strengthen the field of openness of science and to promote a worldwide culture that might lead to unprecedented growth of scientific discoveries, which may spark a permanent revolution in science and technology in the near future. The guidelines for participating in this open project by co-authoring this work are described herein. Open Science (in any field of knowledge) can succeed extraordinarily solely by virtue of two simple elements: people willing to collaborate and a suitable online platform. We believe that science would progress substantially if we unite open researchers worldwide using nowadays technology in a clever way so that the results meet the standards required for high-level publications demanded by our current society. We present a simple way to accomplish "Open Science in Open Access Forums."


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Diego A. Forero ◽  
Walter H. Curioso ◽  
George P. Patrinos

AbstractThere has been an important global interest in Open Science, which include open data and methods, in addition to open access publications. It has been proposed that public availability of raw data increases the value and the possibility of confirmation of scientific findings, in addition to the potential of reducing research waste. Availability of raw data in open repositories facilitates the adequate development of meta-analysis and the cumulative evaluation of evidence for specific topics. In this commentary, we discuss key elements about data sharing in open repositories and we invite researchers around the world to deposit their data in them.


2021 ◽  
Author(s):  
Martin Donnelly

Open Science is integral to the Royal Society of Chemistry’s organisational mission: to support the chemical science community to make the world a better place. It is essential to address global issues (such as current and future pandemics, and climate change) at a quicker pace than ever before, and in fundamentally more collaborative ways. We believe that science which is carried out in a more open and transparent manner has the promise to increase the quality, robustness, longevity, trustworthiness and global impact of the work and its outcomes. We recognise that publishers have not always been considered fellow-travellers in the Open movement, but as a not-for-profit publisher we believe we have an important role to play, learning from all of the stakeholders in the scientific ecosystem, from researchers to librarians and research funders, and providing leadership among our fellow publishers, large and small. As we seek to continually increase the proportion of our articles that are published as Open Access, we face a number of challenges, not least of which are the need for Open Science to be properly funded, with clear, common codes of practice and globally suitable solutions that go beyond equality to a position of international equity. In this talk we will present the thinking and rationale around our recent and forthcoming developments, including the introduction of Data Availability Statements, transparent peer review, author contribution statements (following the CRediT taxonomy), Open Access books, and our support for engendering a more Open research culture across our community. We want this to be the beginning of a genuinely collaborative and open conversation about the concrete actions that publishers such as ourselves can perform or support in order to further our shared goals.


2018 ◽  
Vol 1 (1) ◽  
pp. 6-21 ◽  
Author(s):  
I. K. Razumova ◽  
N. N. Litvinova ◽  
M. E. Shvartsman ◽  
A. Yu. Kuznetsov

Introduction. The paper presents survey results on the awareness towards and practice of Open Access scholarly publishing among Russian academics.Materials and Methods. We employed methods of statistical analysis of survey results. Materials comprise results of data processing of Russian survey conducted in 2018 and published results of the latest international surveys. The survey comprised 1383 respondents from 182 organizations. We performed comparative studies of the responses from academics and research institutions as well as different research areas. The study compares results obtained in Russia with the recently published results of surveys conducted in the United Kingdom and Europe.Results. Our findings show that 95% of Russian respondents support open access, 94% agree to post their publications in open repositories and 75% have experience in open access publishing. We did not find any difference in the awareness and attitude towards open access among seven reference groups. Our analysis revealed the difference in the structure of open access publications of the authors from universities and research institutes. Discussion andConclusions. Results reveal a high level of awareness and support to open access and succeful practice in the open access publications in the Russian scholarly community. The results for Russia demonstrate close similarity with the results of the UK academics. The governmental open access policies and programs would foster the practical realization of the open access in Russia.


2020 ◽  
Author(s):  
Matheus Pereira Lobo

A huge collaborative open science model is proposed. Many authors collaborating in a paper leads to a substantial reduction for the Article Processing Charges (APCs) in the Open Access Journals. This can significantly stimulate research within a healthier citizen and open science culture.


2020 ◽  
Vol 63 (8) ◽  
pp. 1216-1230 ◽  
Author(s):  
Wei Guo ◽  
Sujuan Qin ◽  
Jun Lu ◽  
Fei Gao ◽  
Zhengping Jin ◽  
...  

Abstract For a high level of data availability and reliability, a common strategy for cloud service providers is to rely on replication, i.e. storing several replicas onto different servers. To provide cloud users with a strong guarantee that all replicas required by them are actually stored, many multi-replica integrity auditing schemes were proposed. However, most existing solutions are not resource economical since users need to create and upload replicas of their files by themselves. A multi-replica solution called Mirror is presented to overcome the problems, but we find that it is vulnerable to storage saving attack, by which a dishonest provider can considerably save storage costs compared to the costs of storing all the replicas honestly—while still can pass any challenge successfully. In addition, we also find that Mirror is easily subject to substitution attack and forgery attack, which pose new security risks for cloud users. To address the problems, we propose some simple yet effective countermeasures and an improved proofs of retrievability and replication scheme, which can resist the aforesaid attacks and maintain the advantages of Mirror, such as economical bandwidth and efficient verification. Experimental results show that our scheme exhibits comparable performance with Mirror while achieving high security.


2021 ◽  
pp. bmjstel-2020-000797
Author(s):  
Fabrizio Consorti ◽  
Gianmarco Panzera

BackgroundMany studies explored the use of simulation in basic surgical education, with a variety of devices, contexts and outcomes, with sometimes contradictory results.ObjectivesThe objectives of this meta-analysis were to focus the effect that the level of physical resemblance in a simulation has on the development of basic surgical skill in undergraduate medical students and to provide a foundation for the design and implementation of a simulation, with respect to its effectiveness and alignment with the learning outcomes.Study selectionWe searched PubMed and Scopus database for comparative randomised studies between simulations with a different level of resemblance. The result was synthesised as the standardised mean difference, under a random effect model.FindingsWe selected 12 out of 2091 retrieved studies, reporting on 373 undergraduate students (mean of subjects 15.54±6.89). The outcomes were the performance of simple skills and the time to complete a task. Two studies reported a scoring system; seven studies reported time for a task; and three studies reported both. The total number of measures included in the meta-analysis was 456 for score and 504 for time. The pooled effect size did not show any significant advantage in a simulation of a high level of physical resemblance over a lower level, both for the scoring system (−0.19, 95% CI −0.44 to 0.06) and for time (−0.14, 95% CI −0.54 to 0.27).ConclusionSimulations with a low level of physical resemblance showed the same effect as the simulation using a higher level of resemblance on the development of basic surgical skills in undergraduate students.


ABI-Technik ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 41-47
Author(s):  
Maike Neufend ◽  
Maxi Kindling
Keyword(s):  

2020 ◽  
Vol 163 (3) ◽  
pp. 428-443
Author(s):  
Usman Khan ◽  
Jake MacPherson ◽  
Michael Bezuhly ◽  
Paul Hong

Objective To compare the effectiveness of conventional (CF), laser (LF), and Z-plasty (ZF) frenotomies for the treatment of ankyloglossia in the pediatric population. Data Sources A comprehensive search of PUBMED, EMBASE, and COCHRANE databases was performed. Review Methods Relevant articles were independently assessed by 2 reviewers according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Results Thirty-five articles assessing CF (27 articles), LF (4 articles), ZF (3 articles), and/or rhomboid plasty frenotomy (1 article) were included. A high level of outcome heterogeneity prevented pooling of data. All 7 randomized controlled trials (RCTs) were of low quality. Both CF (5 articles with 589 patients) and LF (2 articles with 78 patients) were independently shown to reduce maternal nipple pain on a visual analog or numeric rating scale. There were reports of improvement with breastfeeding outcomes as assessed on validated assessment tools for 88% (7/8) of CF articles (588 patients) and 2 LF articles (78 patients). ZF improved breastfeeding outcomes on subjective maternal reports (1 article with 18 infants) only. One RCT with a high risk of bias concluded greater speech articulation improvements with ZF compared to CF. Only minor adverse events were reported for all frenotomy techniques. Conclusions Current literature does not demonstrate a clear advantage for one frenotomy technique when managing children with ankyloglossia. Recommendations for future research are provided to overcome the methodological shortcomings in the literature. We conclude that all frenotomy techniques are safe and effective for treating symptomatic ankyloglossia.


Science ◽  
2020 ◽  
Vol 368 (6491) ◽  
pp. 574-577 ◽  
Author(s):  
Claudio Aspesi ◽  
Amy Brand
Keyword(s):  

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