scholarly journals Author response: Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

2020 ◽  
Author(s):  
Danae E Zamboulis ◽  
Chavaunne T Thorpe ◽  
Yalda Ashraf Kharaz ◽  
Helen L Birch ◽  
Hazel RC Screen ◽  
...  
Keyword(s):  
Mechanical Loading ◽  
Author Response ◽  
Collagenous Matrix

scholarly journals Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

2020 ◽  
Author(s):  
D. E. Zamboulis ◽  
C. T. Thorpe ◽  
Y. Ashraf Kharaz ◽  
H. L. Birch ◽  
H. R. C. Screen ◽  
...  
Keyword(s):  
Mechanical Loading ◽  
Collagen Fibre ◽  
Matrix Phase ◽  
Functional Adaptation ◽  
Environmental Cues ◽  
Functional Requirements ◽  
Connective Tissues ◽  
Specific Analysis ◽  
Collagenous Matrix ◽  
Compositional Changes

AbstractMature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However, the temporal nature and drivers of functional adaptation remain undefined. Here, we explore functional adaptation and specialisation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which the collagen (fibre phase) and surrounding predominantly non-collagenous matrix (matrix phase) can be interrogated independently. Using an equine model of late development, we report the first phase-specific analysis of biomechanical, structural and compositional changes seen in functional adaptation, demonstrating adaptation occurs postnatally, following mechanical loading, and is almost exclusively localised to the non-collagenous matrix phase. These novel data redefine adaptation in connective tissue, highlighting the fundamental importance of non-collagenous matrix and suggesting that regenerative medicine strategies should change focus from the fibrous to the non-collagenous matrix phase of tissue.

scholarly journals Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Danae E Zamboulis ◽  
Chavaunne T Thorpe ◽  
Yalda Ashraf Kharaz ◽  
Helen L Birch ◽  
Hazel RC Screen ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Mechanical Loading ◽  
Functional Adaptation ◽  
Environmental Cues ◽  
Late Development ◽  
Functional Requirements ◽  
Connective Tissues ◽  
Specific Analysis ◽  
Collagenous Matrix ◽  
Compositional Changes

Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However, the temporal nature and drivers of functional adaptation remain undefined. Here, we explore functional adaptation and specialisation of mechanically loaded tissues using tendon; a simple aligned biological composite, in which the collagen (fascicle) and surrounding predominantly non-collagenous matrix (interfascicular matrix) can be interrogated independently. Using an equine model of late development, we report the first phase-specific analysis of biomechanical, structural, and compositional changes seen in functional adaptation, demonstrating adaptation occurs postnatally, following mechanical loading, and is almost exclusively localised to the non-collagenous interfascicular matrix. These novel data redefine adaptation in connective tissue, highlighting the fundamental importance of non-collagenous matrix and suggesting that regenerative medicine strategies should change focus from the fibrous to the non-collagenous matrix of tissue.

Author response for "Location and arrangement of campaniform sensilla in Drosophila melanogaster"

2020 ◽  
Author(s):  
Gesa F. Dinges ◽  
Alexander S. Chockley ◽  
Till Bockemühl ◽  
Kei Ito ◽  
Alexander Blanke ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Author Response ◽  
Campaniform Sensilla

Author response for "Distribution and co‐expression of adrenergic receptor‐encoding mRNA in the mouse inferior colliculus"

2020 ◽  
Author(s):  
Charles A. Williams ◽  
Kimberly E. Miller ◽  
Nisa P. Williams ◽  
Christine V. Portfors ◽  
David J. Perkel
Keyword(s):  
Inferior Colliculus ◽  
Adrenergic Receptor ◽  
Author Response
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