ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain
Keyword(s):
CNS neurons have no sensory function, protected by the skull. For this reason, brain neuromodulation by ultrasound were either done at a high intensity or through auditory nerves. We demonstrate in this study CNS neurons react to ultrasound stimulation at an intensity (5 mW/cm2) far lower than typical therapeutic ultrasound (>30 mW/cm2). Using micropipette ultrasound in calcium imaging, we show ASIC1a channels play a role in the reactions of CNS neurons to ultrasound, pointing to the molecular basis for direct ultrasound neuromodulation at low intensity. Furthermore, we also show evidence of neurogenesis with the same ultrasound stimulation, suggesting potential therapeutic translation.
2020 ◽
2017 ◽
Vol 43
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pp. S2
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Keyword(s):
Pulsed versus continuous low-intensity ultrasound stimulation in distraction osteogenesis in rabbits
2005 ◽
Vol 34
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pp. 81-82
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2004 ◽
Vol 116
(3)
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pp. 1336
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2003 ◽
Vol 23
(1)
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pp. 46-51
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Keyword(s):
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2010 ◽
Vol 29
(1)
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pp. 116-125
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Keyword(s):
2008 ◽
Vol 29
(10)
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pp. 970-977
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