scholarly journals Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Laifu Li ◽  
Li-Zi Zhang ◽  
Zhi-Xiong He ◽  
Huan Ma ◽  
Yu-Ting Zhang ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Neural Circuit ◽  
Dorsal Raphe Nucleus ◽  
Cingulate Cortex ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Anterior Cingulate ◽  
Common Response ◽  
Socially Monogamous ◽  
Dorsal Raphé

Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. By using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nucleus (DR) or optogenetic inhibition of 5-HT terminals in the anterior cingulate cortex (ACC) significantly decreased allogrooming time in the consolation test and reduced sociability in the three-chamber test. The release of 5-HT within the ACC and the activity of DR neurons were significantly increased during allogrooming, sniffing and social approaching. Finally, we found that the activation of 5-HT1A receptors in the ACC was sufficient to reverse consolation and sociability deficits induced by the chemogenetic inhibition of 5-HTergic neurons in the DR. Our study provided first direct evidence that DR-ACC 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability.

scholarly journals Dorsal raphe nuclei to anterior cingulate cortex 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability in mandarin voles

2020 ◽  
Author(s):  
Lai-Fu Li ◽  
Li-Zi Zhang ◽  
Zhi-Xiong He ◽  
Wei Yuan ◽  
Huan Ma ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Direct Evidence ◽  
Neural Circuit ◽  
Cingulate Cortex ◽  
Dorsal Raphe ◽  
Anterior Cingulate ◽  
Raphe Nuclei ◽  
Socially Monogamous ◽  
Raphé Nuclei ◽  
Dorsal Raphé

ABSTRACTConsolation is a common empathetic response in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized. Here, by using socially monogamous mandarin voles, we found that optogenetic or chemogenetic inhibition of 5-HTergic neurons in the dorsal raphe nuclei (DR) or optogenetic inhibition of 5-HT terminals in the anterior cingulate cortex (ACC) significantly decreased the allogrooming time in the consolation test and reduced sociability in the three-chamber test. Fiber photometry results showed that the release of 5-HT within the ACC and the activity of DR neurons were significantly increased when allogrooming and social approaching occurred. Finally, we found that the activation of 5-HT1A receptors in the ACC was sufficient to reverse consolation and sociability deficits induced by the chemogenetic inhibition of 5-HTergic neurons in the DR. Our study provided first direct evidence that DR→ACC 5-HTergic neural circuit is implicated in consolation-like behaviors and sociability in mandarin voles.

scholarly journals Disconnectivity between Dorsal Raphe Nucleus and Posterior Cingulate Cortex in Later Life Depression

2017 ◽  
Vol 9 ◽  
Author(s):  
Toshikazu Ikuta ◽  
Koji Matsuo ◽  
Kenichiro Harada ◽  
Mami Nakashima ◽  
Teruyuki Hobara ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Cingulate Cortex ◽  
Later Life ◽  
Dorsal Raphe ◽  
Posterior Cingulate Cortex ◽  
Raphe Nucleus ◽  
Posterior Cingulate ◽  
Dorsal Raphé

scholarly journals Neural Circuit in the Dorsal Raphe Nucleus Responsible for Cannabinoid-Mediated Increases in 5-HT Efflux in the Nucleus Accumbens of the Rat Brain

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Rui Tao ◽  
Zhiyuan Ma
Keyword(s):  
Nucleus Accumbens ◽  
Indirect Effect ◽  
Indirect Effects ◽  
Neural Circuit ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Direct And Indirect Effects ◽  
Dorsal Raphé

In vivo microdialysis was used in this study to reveal the role of cannabinoids in regulating serotonin (5-HT) efflux in the nucleus accumbens (NAcc) and dorsal raphe nucleus (DRN). The cannabinoid CB1 receptor agonists WIN55212-2 and CP55940 systematically administered to rats caused significant increases in 5-HT efflux in the NAcc but failed to have an effect in the DRN. To reveal mechanisms underlying regionally selective responses, we tested the hypothesis that cannabinoids have both direct and indirect effects on 5-HT efflux, depending on the location of CB1 receptors in the neural circuit between DRN and NAcc. We showed that the direct effect of cannabinoids caused a reduction in 5-HT efflux whereas the indirect effect resulted in an increase. Furthermore, the indirect effect was blocked by the GABAA receptor antagonist bicuculline in the DRN, suggesting that the action is likely due to a presynaptic inhibition on GABAergic activity that exerts a tonic influence on neuronal circuits regulating 5-HT efflux. Involvement of GABAergic neurons was confirmed by measuring changes in GABA efflux. Taken together, our study suggests that cannabinoids may have direct and indirect effects on the 5-HT regulatory circuits, resulting in regionally selective changes of 5-HT efflux in the brain.

scholarly journals Neural Circuit Interactions between the Dorsal Raphe Nucleus and the Lateral Hypothalamus: An Experimental and Computational Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88003 ◽  
Author(s):  
Jaishree Jalewa ◽  
Alok Joshi ◽  
T. Martin McGinnity ◽  
Girijesh Prasad ◽  
KongFatt Wong-Lin ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Neural Circuit ◽  
Dorsal Raphe Nucleus ◽  
Computational Study ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé

Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats

2010 ◽  
Vol 473 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Ali Jahanshahi ◽  
Lee Wei Lim ◽  
Harry W.M. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
Yasin Temel
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Induced Changes ◽  
Dorsal Raphé

027 GABAergic Neurons in the Dorsal Raphe Nucleus Are under the Influence of GABAergic Inputs from the Nucleus Pontis Oralis

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A12-A12
Author(s):  
Jianhua Zhang ◽  
Mingchu Xi ◽  
Simon Fung ◽  
Charles Tobin ◽  
Sharon Sampogna ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Gabaergic Neurons ◽  
Fluorescent Labeling ◽  
Raphe Nucleus ◽  
Gaba A ◽  
Adult Cats ◽  
Immunohistochemical Techniques ◽  
Fluorescence Immunohistochemistry ◽  
Dorsal Raphé

Abstract Introduction Our previous study has shown that there is a direct connection between GABAergic neurons in the nucleus pontis oralis (NPO) and neurons of the dorsal raphe nucleus (DR), providing a morphological basis for the hypothesis that GABAergic inhibitory processes in NPO play an important role in the generation and maintenance of wakefulness as well as active (REM) sleep through the interaction with neurons in the DR. However, the target of such a GABAergic projection from the NPO within the DR is unknown. In the present study, a double-fluorescent labeling technique was employed to examine the target of GABAergic inputs to the DR. Methods Adult cats were deeply anesthetized and perfused transcardially. Subsequently, the brainstem containing the DR was removed, postfixed and cut into 15 μm coronal sections with a Reichert-Jung cryostat. The sections were immunostained with antibodies against GABA-A or GABA-B receptors and GABA following the procedure of double fluorescence immunohistochemistry. Results Under fluorescence microscopy, a large number of neurons were labeled with antibodies against either GABA-A receptor or GABA-B receptor. In addition, neurons labeled with antibody against GABA were observed in the DR. With double fluorescence immunohistochemical techniques, some neurons labeled by anti-GABA antibody were also stained with antibodies against GABA-A or GABA-B receptors. Conclusion The expression of GABA-A or GABA-B receptors by GABAergic neurons in the DR indicates that GABAergic neurons in the DR receive GABAergic inputs. Our previous study has demonstrated that these GABAergic inputs are from the NPO. These data provide a morphological foundation to support our hypothesis that, during wakefulness, NPO GABAergic “Executive” neurons suppress “Second-Order” GABAergic neurons in the DR, which, in turn, activate (disinhibit) serotonergic wake-on neurons in this nucleus. Support (if any) NS092383

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