scholarly journals A2B Blood Group Without Anti-A1 Lectin Antibodies in a Child With an Enzymopathy Hemolytic Disease

Cureus ◽  
2021 ◽  
Author(s):  
Fadi Busaleh ◽  
Dunya Bu-Izran ◽  
Zainab Alhajji ◽  
Rawya Qahtan ◽  
Abdulatif Alnaaim ◽  
...  
Keyword(s):  
Blood Group ◽  
Hemolytic Disease

HEMOLYTIC DISEASE OF THE NEWBORN DUE TO ANTI-A AND ANTI-B

PEDIATRICS ◽  
1955 ◽  
Vol 15 (1) ◽  
pp. 54-62
Author(s):  
Clare N. Shumway ◽  
Gerald Miller ◽  
Lawrence E. Young
Keyword(s):  
B Cells ◽  
Red Blood Cells ◽  
Blood Group ◽  
Newborn Infant ◽  
Blood Cells ◽  
Osmotic Fragility ◽  
Red Cells ◽  
Hemolytic Disease ◽  
Abo Incompatibility

Ten infants with hemolytic disease of the newborn due to ABO incompatibility were studied. In every case the investigations were undertaken because of jaundice occurring in the first 24 hours of life. The clinical, hematologic and serologic observations in the infants and the serologic findings in the maternal sera are described. Evidence is presented to show that the diagnosis of the disorder rests largely upon the demonstration of spherocytosis, increased osmotic fragility of the red cells, reticulocytosis, and hyperbilirubinemia in a newborn infant whose red blood cells are incompatible with the maternal major blood group isoantibody and against whose cells no other maternal isoantibody is demonstrable. The anti-A or anti-B in each of the maternal sera tested in this series hemolyzed A or B cells in the presence of complement. Other serologic findings in the maternal sera were less consistently demonstrated.

scholarly journals AB0-incompatibility of mother and fetus: the role of anti-glycan alloantibodies in the hemolytic disease of newborns

2021 ◽  
Vol 23 (1) ◽  
pp. 17-34
Author(s):  
P. S. Obukhova ◽  
A. V. Kachanov ◽  
N. A. Pozdnyakova ◽  
M. M. Ziganshina
Keyword(s):  
Red Blood Cells ◽  
Blood Group ◽  
Blood Cells ◽  
Hemolytic Disease ◽  
Disease Condition ◽  
Mother And Child ◽  
Group A ◽  
Group B ◽  
Maternal Igg

The mother and fetus incompatibility due to Rh-factor, blood group or other blood factors can lead to hemolytic disease of the fetus and newborn (HDN). HDN is a clinical disease condition of the fetus and newborn as a result of hemolysis, when maternal IgG alloantibodies cross the placenta and destroy the red blood cells of the fetus and newborn. The child disease begins in utero and can dramatically increase immediately after birth. As a result, hyperbilirubinemia and anemia develop, that can lead to abortions, serious complications, or death of the neonates in the absence of proper therapy. The range of HDN has changed significantly now compared to previous decades. Half a century ago, HDN was considered an almost complete synonym of RhD-alloimmunization, and this was a frequent problem for newborns. By now due to the high effective of Rh-conflict prevention, immunological AB0-conflicts have become the most common cause of HDN. The review aimes to one of the main causes of jaundice and anemia in neonates at present, i.e. HDN due to immunological AB0-conflict of mother and newborn (AB0-HDN). The main participants of the AВ0- incompatibility mother and child are considered, namely A- and B-glycans, as well as the corresponding anti-glycan alloantibodies. Close attention is paid to the structure features of glycan alloantigens on the red blood cells of the fetus and adult. The possible correlation of the frequency and severity of HDN with the blood group of mother and child, as well as with the titer of maternal alloantibodies, has been considered. The influence of immunoglobulin G subclasses on the AB0-HDN development has been evaluated. In most cases, AB0-HDN appear when the mother has the blood group 0, and the fetus has the group A (subgroup A1) or the group B. Other rare incidences of AB0-incompatibility with severe course are occurred. As a whole the etiology of AB0-HDN is complex and the HDN severity is influenced by many factors. The authors have analyzed statistical data, as well as the prevalence of AB0-incompatibility and AB0-HDN in various regions of the world. Current approaches to the diagnosis of AB0-HDN are discussed in addition. By now the problems of AB0- HDN occurrence and developing of ways to overcome this disease remain relevant.

scholarly journals Hemolytic Disease of the Newborn Due to Anti-A

Blood ◽  
1953 ◽  
Vol 8 (7) ◽  
pp. 620-639 ◽  
Author(s):  
HAL CRAWFORD ◽  
MARIE CUTBUSH ◽  
P. L. MOLLISON
Keyword(s):  
Blood Group ◽  
Osmotic Fragility ◽  
Red Cells ◽  
Coombs Test ◽  
Hemolytic Disease ◽  
A Cells

Abstract Eleven cases of hemolytic disease of the newborn are described in which the only blood group antibody in the mother's serum, incompatible with the infant's cells, was anti-A. The direct antiglobulin (Coombs) test on the infant's red cells was weakly positive in 7 cases and negative in 4 cases. In every case the mother's serum displayed immune characteristics, in particular the ability to lyse A cells. Osmotic fragility was increased in 10 out of 11 cases. This finding is contrasted with those in a series of cases of hemolytic disease of the newborn due to anti-Rh.

scholarly journals THE SIGNIFICANCE OF ABO COMPATIBILITY AND ITS RELATIONSHIP TO THE INTENSITY OF RH IMMUNIZATION

Blood ◽  
1950 ◽  
Vol 5 (8) ◽  
pp. 767-772 ◽  
Author(s):  
S. P. LUCIA ◽  
MARJORIE L. HUNT
Keyword(s):  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Hemolytic Disease ◽  
Mother And Child ◽  
Group A ◽  
Obstetric Population ◽  
Rh Immunization

Abstract 1. A series of 1337 obstetric cases, of which 170 were instances of sensitized Rh negative women, were studied with regard to (a) the incidence of the ABO blood groups, and (b) the incidence of ABO compatibility between the mother and child. 2. The incidence of ABO compatibility between the mother and child was found to vary with the blood group of the mother. 3. ABO compatibility between the mother and child was found to be present in 80 per cent of an unselected obstetric population in contrast to 95 per cent in a group of sensitized Rh negative women who bore infants afflicted with hemolytic disease of the newborn. 4. ABO compatibility appears to be related to the occurrence of hemolytic disease of the newborn. 5. In 120 sensitized Rh negative women who bore afflicted infants, the incidence of group A mothers was greater than expected.

Treatment of ABO Hemolytic Disease with Synthetic Blood Group Trisaccharides

Vox Sanguinis ◽  
1994 ◽  
Vol 66 (3) ◽  
pp. 194-199 ◽  
Author(s):  
Egidio L. Romano ◽  
Andres Soyano ◽  
Ramón F. Montaño ◽  
Murray Ratcliffe ◽  
Marilyn Olson ◽  
...  
Keyword(s):  
Blood Group ◽  
Hemolytic Disease ◽  
Abo Hemolytic Disease

Red cell genotyping and the future of pretransfusion testing

Blood ◽  
2009 ◽  
Vol 114 (2) ◽  
pp. 248-256 ◽  
Author(s):  
David J. Anstee
Keyword(s):  
At Risk ◽  
Blood Group ◽  
Blood Group Antigens ◽  
Red Cell ◽  
Cell Disease ◽  
Hemolytic Disease ◽  
The Past ◽  
Patients At Risk ◽  
Almost All ◽  
Molecular Bases

Abstract Over the past 20 years the molecular bases of almost all the major blood group antigens have been determined. This research has enabled development of DNA-based methods for determining blood group genotype. The most notable application of these DNA-based methods has been for determining fetal blood group in pregnancies when the fetus is at risk for hemolytic disease of the fetus and newborn. The replacement of all conventional serologic methods for pretransfusion testing by molecular methods is not straightforward. For the majority of transfusion recipients matching beyond ABO and D type is unnecessary, and the minority of untransfused patients at risk of alloimmunization who would benefit from more extensively blood group–matched blood cannot be identified reliably. Even if a method to identify persons most likely to make alloantibodies were available, this would not of itself guarantee the provision of extensively phenotype-matched blood for these patients because this is determined by the size and racial composition of blood donations available for transfusion. However, routine use of DNA-based extended phenotyping to provide optimally matched donations for patients with preexisting antibodies or patients with a known predisposition to alloimmunization, such as those with sickle cell disease, is widely used.

scholarly journals Severe hemolytic disease of the premature newborn due to RH1 incompatibility: a case report

2016 ◽  
Vol 89 (4) ◽  
pp. 565-568 ◽  
Author(s):  
Jean Uwingabiye ◽  
Hafid Zahid ◽  
Fayçal Labrini ◽  
Abdelhak El Khazraji ◽  
Anass Yahyaoui ◽  
...  
Keyword(s):  
Blood Group ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Total Serum ◽  
Hemolytic Disease ◽  
Close Collaboration ◽  
Haemolytic Disease ◽  
Total Serum Bilirubin Level ◽  
Antiglobulin Test ◽  
History Of

We report a case of dramatic outcome of severe haemolytic disease in a newborn due to RH1 incompatibility. A newborn with A RH1 blood group was admitted in the Mohammed V Military Teaching Hospital for the problem of hydrops fetalis associated with RH1 incompatibility. The blood group of his mother, aged 31, was AB RH1-negative and that of his 37 year old father was A RH1.The mother had a history of 4 term deliveries, 3 abortions, and 1 living child. There was no prevention by anti-D immunoglobulin postpartum. The mother‘s irregular agglutinin test was positive and the pregnancy was poorly monitored. The laboratory tests of the newborn showed a high total serum bilirubin level (30 mg/L) and macrocytic regenerative anemia (Hemoglobin=4 g/dL, mean corpuscular volume = 183 fL, reticulocytes count =176600/m3). The blood smear showed 1256 erythroblasts per 100 leukocytes, Howell–Jolly bodies and many macrocytes. The direct antiglobulin test was positive. He was transfused with red blood cell concentrates and treated with conventional phototherapy. The evolution was unfavourable; he died three days after the death of his mother. The monitoring of these high-risk pregnancies requires specialized centers and a close collaboration between the gynaecologist and the blood transfusion specialist to strengthen the prevention, as well as clinico-biological monitoring in patients with a history of RH1 fetomaternal alloimunization.

scholarly journals Effect of Rhesus Negative in Pregnancy

2018 ◽  
Vol 30 (1) ◽  
pp. 23-25
Author(s):  
Jamila Khatun ◽  
Ruly Begum
Keyword(s):  
Blood Group ◽  
Perinatal Outcome ◽  
Neonatal Death ◽  
Maternal Blood ◽  
Perinatal Morbidity ◽  
Hemolytic Disease ◽  
Medical College ◽  
Mild Anaemia ◽  
Group B ◽  
Rh Immunization

Hemolytic disease of the newborn due to Rhisoimmunisation is a major cause to perinatal morbidity & mortality. Erythroblastosis fetalis is a disease of fetus and newborn due to incompatibility between fetal and maternal blood group. Diagnosis and therapy for Rh immunization improved considerably. Its prevention by immunoprophylaxis has been responsible for the reduction in the incidence of perinatal mobility. Still Rh immunization and erythroolastosis fetalis is responsible for many obstetric mishaps in our country. To see the pregnancy outcome of Rhesus negative women. This prospective study was carried out from October 2013 to March 2014 in Obstetrics & Gynecology department of Sylhet MAG Osmani Medical College & Hospital, Sylhet. 50 Rh-negative pregnancies were selected those who got admitted in department of Obstetrics & Gynecology, SOMCH. 30.62% of the fetuses had blood group B+ve, 24.40% 0+ve and 20.40% A+ve. Regarding the perinatal outcome 76% were healthy, 4% still birth, 4% neonatal death, 14% with erythroblastosis foetalis and 4% developed hydrops. Mild anaemia and oedema was common in primi and multigravida patients. PET was found 6.2% in multigravida patients. APH and Hydramnios with congenital anomalies were 3.1% and 3.1% respectively. This study was undertaken to evaluate the outcome of pregnancy in Rh -ve women. It is preventable. Primary prevention of isoimmunization by giving combined antenatal and postnatal prophylaxis.Medicine Today 2018 Vol.30(1): 23-25

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